Search Results - "Weller, Shaun"

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes by Schott, Micah B, Weller, Shaun G, Schulze, Ryan J, Krueger, Eugene W, Drizyte-Miller, Kristina, Casey, Carol A, McNiven, Mark A

“…Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a selective autophagic mechanism called lipophagy, but the relative…”
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Direct lysosome-based autophagy of lipid droplets in hepatocytes by Schulze, Ryan J., Krueger, Eugene W., Weller, Shaun G., Johnson, Katherine M., Casey, Carol A., Schott, Micah B., McNiven, Mark A.

“…Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelleselective form of this process…”
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The small GTPase Rab7 as a central regulator of hepatocellular lipophagy by Schroeder, Barbara, Schulze, Ryan J., Weller, Shaun G., Sletten, Arthur C., Casey, Carol A., McNiven, Mark A.

“…Autophagy is a central mechanism by which hepatocytes catabolize lipid droplets (LDs). Currently, the regulatory mechanisms that control this important process…”
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Lipophagy at a glance by Schott, Micah B, Rozeveld, Cody N, Weller, Shaun G, McNiven, Mark A

“…Lipophagy is a central cellular process for providing the cell with a readily utilized, high energy source of neutral lipids. Since its discovery over a decade…”
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Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes by Schulze, Ryan J, Weller, Shaun G, Schroeder, Barbara, Krueger, Eugene W, Chi, Susan, Casey, Carol A, McNiven, Mark A

“…Lipid droplets (LDs) are lipid storage organelles that in hepatocytes may be catabolized by autophagy for use as an energy source, but the membrane-trafficking…”
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Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1 by Qiang, Li, Cao, Hong, Chen, Jing, Weller, Shaun G, Krueger, Eugene W, Zhang, Lizhi, Razidlo, Gina L, McNiven, Mark A

“…The process by which tumor cells mechanically invade through surrounding stroma into peripheral tissues is an essential component of metastatic dissemination…”
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β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure by Schott, Micah B., Rasineni, Karuna, Weller, Shaun G., Schulze, Ryan J., Sletten, Arthur C., Casey, Carol A., McNiven, Mark A.

“…In liver steatosis (i.e. fatty liver), hepatocytes accumulate many large neutral lipid storage organelles known as lipid droplets (LDs). LDs are important in…”
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Maturation of Lipophagic Organelles in Hepatocytes Is Dependent Upon a Rab10/Dynamin‐2 Complex by Li, Zhipeng, Weller, Shaun G., Drizyte‐Miller, Kristina, Chen, Jing, Krueger, Eugene W., Mehall, Bridget, Casey, Carol A., Cao, Hong, McNiven, Mark A.

“…Background and Aims Hepatocytes play a central role in storage and utilization of fat by the liver. Selective breakdown of lipid droplets (LDs) by autophagy…”
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Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2 by Weller, Shaun G., Capitani, Micro, Cao, Hong, Micaroni, Massimo, Luini, Alberto, Sallese, Michele, McNiven, Mark A., Sabatini, David D.

“…The size and integrity of the Golgi apparatus is maintained via a tightly controlled regulation of membrane traffic using a variety of different signaling and…”
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A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization by ORTH, James D, KRUEGER, Eugene W, WELLER, Shaun G, MCNIVEN, Mark A

“…Cells form transient, circular dorsal ruffles or "waves" in response to stimulation of receptor tyrosine kinases, including epidermal growth factor receptor…”
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A Dyn2–CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding by Schroeder, Barbara, Weller, Shaun G, Chen, Jing, Billadeau, Daniel, McNiven, Mark A

“…The epidermal growth factor receptor (EGFR) is over‐expressed in a variety of human cancers. Downstream signalling of this receptor is tightly regulated both…”
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Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7 by Schulze, Ryan J., Rasineni, Karuna, Weller, Shaun G., Schott, Micah B., Schroeder, Barbara, Casey, Carol A., McNiven, Mark A.

“…Alcohol consumption is a well‐established risk factor for the onset and progression of fatty liver disease. An estimated 90% of heavy drinkers are thought to…”
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Ethanol disrupts hepatocellular lipophagy by altering Rab5-centric LD-lysosome trafficking by Schott, Micah B, Rozeveld, Cody N, Bhatt, Saumya, Crossman, Bridget, Krueger, Eugene W, Weller, Shaun G, Rasineni, Karuna, Casey, Carol A, McNiven, Mark A

“…Previous reports suggest that lipid droplets (LDs) in the hepatocyte can be catabolized by a direct engulfment from nearby endolysosomes (microlipophagy)…”
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Cortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis by Cao, Hong, Orth, James D., Chen, Jing, Weller, Shaun G., Heuser, John E., McNiven, Mark A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation by Orlichenko, Lidiya, Weller, Shaun G, Cao, Hong, Krueger, Eugene W, Awoniyi, Muyiwa, Beznoussenko, Galina, Buccione, Roberto, McNiven, Mark A

“…Remodeling of cell-cell contacts through the internalization of adherens junction proteins is an important event during both normal development and the process…”
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Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport by McNiven, Mark A, Cao, Hong, Weller, Shaun, Orth, James D, Chen, Jing, Huang, Bing, Chen, Ji-Long, Stamnes, Mark

“…Cortactin is an actin-binding protein that has recently been implicated in endocytosis. It binds directly to dynamin-2 (Dyn2), a large GTPase that mediates the…”
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A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets by Li, Zhipeng, Schulze, Ryan J, Weller, Shaun G, Krueger, Eugene W, Schott, Micah B, Zhang, Xiaodong, Casey, Carol A, Liu, Jun, Stöckli, Jacqueline, James, David E, McNiven, Mark A

“…The autophagic digestion of lipid droplets (LDs) through lipophagy is an essential process by which most cells catabolize lipids as an energy source. However,…”
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A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding by Schroeder, Barbara, Weller, Shaun G, Chen, Jing, Billadeau, Daniel, McNiven, Mark A

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272 Metastatic Invasion of Pancreatic Ductal Carcinoma is Significantly Increased by Altered Expression and Function of a SRC-Activated Dynamin-Cortactin Complex by Eppinga, Robbin, Weller, Shaun G, Krueger, Eugene, Chen, Jing, Cao, Hong, McNiven, Mark A

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S2032 Pancreatic Tumor Cells Exhibit An Aberrantly Organized Golgi Apparatus That Is Regulated By SRC Kinase and the Large GTPase Dynamin 2 by Weller, Shaun G, Cao, Hong, McNiven, Mark A

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