Search Results - "Weller, Joan L."

Melatonin Synthesis: 14-3-3-Dependent Activation and Inhibition of Arylalkylamine N-Acetyltransferase Mediated by Phosphoserine-205 by Ganguly, Surajit, Weller, Joan L., Ho, Anthony, Chemineau, Philippe, Malpaux, Benoit, Klein, David C., Nathans, Jeremy

“…The nocturnal increase in circulating melatonin in vertebrates is regulated by the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate…”
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Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4) by Kim, Jong-So, Bailey, Michael J., Weller, Joan L., Sugden, David, Rath, Martin F., Møller, Morten, Klein, David C.

“…Dopamine plays diverse and important roles in vertebrate biology, impacting behavior and physiology through actions mediated by specific G-protein-coupled…”
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Pineal function: Impact of microarray analysis by Klein, David C., Bailey, Michael J., Carter, David A., Kim, Jong-so, Shi, Qiong, Ho, Anthony K., Chik, Constance L., Gaildrat, Pascaline, Morin, Fabrice, Ganguly, Surajit, Rath, Martin F., Møller, Morten, Sugden, David, Rangel, Zoila G., Munson, Peter J., Weller, Joan L., Coon, Steven L.

“…Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues…”
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Melatonin pathway: breaking the ‘high-at-night’ rule in trout retina by Besseau, Laurence, Benyassi, Ahmed, Møller, Morten, Coon, Steven L., Weller, Joan L., Boeuf, Gilles, Klein, David C., Falcón, Jack

“…Pineal melatonin synthesis increases at night in all vertebrates, due to an increase in the activity of arylalkylamine N-acetyltransferase (AANAT). Melatonin…”
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Role of a Pineal cAMP-Operated Arylalkylamine N-Acetyltransferase/14-3-3-Binding Switch in Melatonin Synthesis by Ganguly, Surajit, Gastel, Jonathan A., Weller, Joan L., Schwartz, Christian, Jaffe, Howard, Namboodiri, M. A. A., Coon, Steven L., Hickman, Alison B., Rollag, Mark, Obsil, Tomas, Beauverger, Philippe, Ferry, Gilles, Boutin, Jean A., Klein, David C.

“…The daily rhythm in melatonin levels is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase…”
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Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus by Pavlicek, Jiri, Sauzet, Sandrine, Besseau, Laurence, Coon, Steven L, Weller, Joan L, Boeuf, Gilles, Gaildrat, Pascaline, Omelchenko, Marina V, Koonin, Eugene V, Falcón, Jack, Klein, David C

“…The arylalkylamine N-acetyltransferase (AANAT) family is divided into structurally distinct vertebrate and non-vertebrate groups. Expression of vertebrate…”
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Evidence That Proline Focuses Movement of the Floppy Loop of Arylalkylamine N-Acetyltransferase (EC 2.3.1.87) by Pavlicek, Jiri, Coon, Steven L., Ganguly, Surajit, Weller, Joan L., Hassan, Sergio A., Sackett, Dan L., Klein, David C.

“…Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity…”
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Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland by Rath, Martin F, Coon, Steven L, Amaral, Fernanda G, Weller, Joan L, Møller, Morten, Klein, David C

“…The rat pineal gland has been extensively used in studies of melatonin synthesis. However, the cellular localization of melatonin synthesis in this species has…”
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Cellular Stability of Serotonin N-Acetyltransferase Conferred by Phosphonodifluoromethylene Alanine (Pfa) Substitution for Ser-205 by Zheng, Weiping, Schwarzer, Dirk, LeBeau, Aaron, Weller, Joan L., Klein, David C., Cole, Philip A.

“…Large changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) in the pineal gland control the rhythmic production…”
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Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation by Cole, Philip A, Zheng, Weiping, Zhang, Zhongsen, Ganguly, Surajit, Weller, Joan L, Klein, David C

“…Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) controls daily changes in the production and circulating levels of melatonin. Here,…”
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Night/Day Changes in Pineal Expression of >600 Genes: CENTRAL ROLE OF ADRENERGIC/cAMP SIGNALING by Bailey, Michael J, Coon, Steven L, Carter, David A, Humphries, Ann, Kim, Jong-so, Shi, Qiong, Gaildrat, Pascaline, Morin, Fabrice, Ganguly, Surajit, Hogenesch, John B, Weller, Joan L, Rath, Martin F, Møller, Morten, Baler, Ruben, Sugden, David, Rangel, Zoila G, Munson, Peter J, Klein, David C

“…The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night…”
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NeuroD1 is required for survival of photoreceptors but not pinealocytes: Results from targeted gene deletion studies by Ochocinska, Margaret J., Muñoz, Estela M., Veleri, Shobi, Weller, Joan L., Coon, Steven L., Pozdeyev, Nikita, Michael Iuvone, P., Goebbels, Sandra, Furukawa, Takahisa, Klein, David C.

“…NeuroD1 encodes a basic helix‐loop‐helix transcription factor involved in the development of neural and endocrine structures, including the retina and pineal…”
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Global daily dynamics of the pineal transcriptome by Bustos, Diego M, Bailey, Michael J, Sugden, David, Carter, David A, Rath, Martin F, Møller, Morten, Coon, Steven L, Weller, Joan L, Klein, David C

“…Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with…”
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Melatonin Production: Proteasomal Proteolysis in Serotonin N-Acetyltransferase Regulation by Gastel, Jonathan A., Roseboom, Patrick H., Rinaldi, Peter A., Weller, Joan L., Klein, David C.

“…The nocturnal increase in circulating melatonin in vertebrates is regulated by 10- to 100-fold increases in pineal serotonin N-acetyltransferase (AA-NAT)…”
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Regulation of Arylalkylamine N-Acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the Fish Pineal Organ: Evidence for a Role of Proteasomal Proteolysis by Falcón, Jack, Galarneau, Kristina M, Weller, Joan L, Ron, Benny, Chen, Galit, Coon, Steven L, Klein, David C

“…In fish, individual photoreceptor cells in the pineal organ and retina contain complete melatonin rhythm generating systems. In the pike and seabream, this…”
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Pineal Serotonin N-Acetyltransferase: Expression Cloning and Molecular Analysis by Coon, Steven L., Roseboom, Patrick H., Baler, Ruben, Weller, Joan L., Namboodiri, M. A. A., Koonin, Eugene V., Klein, David C.

“…Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that…”
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Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism by Kim, Jong-So, Coon, Steven L, Weller, Joan L, Blackshaw, Seth, Rath, Martin F, Møller, Morten, Klein, David C

“…Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved…”
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Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction : An example from the pineal gland by SCHOMERUS, Christof, KORF, Horst-Werner, LAEDTKE, Elke, WELLER, Joan L, KLEIN, David C

“…The molecular processes underlying neural transmission are central issues in neurobiology. Here we describe a novel mechanism through which noradrenaline (NA)…”
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Night/Day Changes in Pineal Expression of >600 Genes by Bailey, Michael J., Coon, Steven L., Carter, David A., Humphries, Ann, Kim, Jong-so, Shi, Qiong, Gaildrat, Pascaline, Morin, Fabrice, Ganguly, Surajit, Hogenesch, John B., Weller, Joan L., Rath, Martin F., Møller, Morten, Baler, Ruben, Sugden, David, Rangel, Zoila G., Munson, Peter J., Klein, David C.

“…The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night…”
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Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli by Schomerus, Christof, Laedtke, Elke, Olcese, James, Weller, Joan L, Klein, David C, Korf, Horst-Werner

“…Limited studies of the regulation of pineal melatonin biosynthesis in ungulates indicate that it differs considerably from that in rodents. Here we have…”
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