Search Results - "Weller, Caroline"

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery by Zhou, Jiangbing, Liu, Jie, Cheng, Christopher J., Patel, Toral R., Weller, Caroline E., Piepmeier, Joseph M., Jiang, Zhaozhong, Saltzman, W. Mark

“…Many synthetic polycationic vectors for non-viral gene delivery show high efficiency in vitro , but their usually excessive charge density makes them toxic for…”
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Facile Semisynthesis of Ubiquitylated Peptides with the Ligation Auxiliary 2-Aminooxyethanethiol by Weller, Caroline E, Chatterjee, Champak

“…The posttranslational modification of cellular proteins by ubiquitin (Ub), called ubiquitylation, is indispensable for the normal growth and development of…”
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Facile Synthesis of Native and Protease-Resistant Ubiquitylated Peptides by Weller, Caroline E., Huang, Wei, Chatterjee, Champak

“…The reversible post‐translational modification of eukaryotic proteins by ubiquitin regulates key cellular processes including protein degradation and gene…”
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Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20 by Li, Heng, Lim, Kah Suan, Kim, Hyungjin, Hinds, Thomas R., Jo, Ukhyun, Mao, Haibin, Weller, Caroline E., Sun, Ji, Chatterjee, Champak, D’Andrea, Alan D., Zheng, Ning

“…Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is often modulated by their binding…”
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Polymer nanoparticles encapsulating siRNA for treatment of HSV-2 genital infection by Steinbach, Jill M., Weller, Caroline E., Booth, Carmen J., Saltzman, W. Mark

“…Effective, low-cost, and safe treatments for sexually transmitted viral infections are urgently needed. Here, we show for the first time that intravaginal…”
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Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1–CoREST Complex by Dhall, Abhinav, Weller, Caroline E, Chu, Aurea, Shelton, Patrick M. M, Chatterjee, Champak

“…Lysine-specific demethylase 1 (LSD1) downregulates eukaryotic gene activity by demethylating mono- and dimethylated Lys4 in histone H3. Elucidating the…”
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A Facile N-Mercaptoethoxyglycinamide (MEGA) Linker Approach to Peptide Thioesterification and Cyclization by Shelton, Patrick M M, Weller, Caroline E, Chatterjee, Champak

“…The C-terminal electrophilic activation of peptides by α-thioesterification requires strongly acidic conditions or complex chemical manipulations, which…”
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Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins by Weller, Caroline E., Dhall, Abhinav, Ding, Feizhi, Linares, Edlaine, Whedon, Samuel D., Senger, Nicholas A., Tyson, Elizabeth L., Bagert, John D., Li, Xiaosong, Augusto, Ohara, Chatterjee, Champak

“…Access to protein substrates homogenously modified by ubiquitin (Ub) is critical for biophysical and biochemical investigations aimed at deconvoluting the…”
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Chemical strategies to understand the language of ubiquitin signaling by Weller, Caroline E., Pilkerton, Meagan E., Chatterjee, Champak

“…ABSTRACT Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all eukaryotes studied to date. In humans, more than 600 ligases are…”
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Selenocysteine as a Latent Bioorthogonal Electrophilic Probe for Deubiquitylating Enzymes by Whedon, Samuel D, Markandeya, Nagula, Rana, Ambar S. J. B, Senger, Nicholas A, Weller, Caroline E, Tureček, Frantisek, Strieter, Eric R, Chatterjee, Champak

“…Deubiquitylating enzymes (DUBs) remove ubiquitin (Ub) from various cellular proteins and render eukaryotic ubiquitylation a dynamic process. The misregulation…”
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All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting by Weller, Caroline E., Chatterjee, Champak

“…Endless potential: The sixth Chemical Protein Synthesis Meeting, held recently in St. Augustine, Florida, showed the potential of peptide and protein chemistry…”
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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts by Leonen, Calvin Jon A, Shimada, Miho, Weller, Caroline E, Nakadai, Tomoyoshi, Hsu, Peter L, Tyson, Elizabeth L, Mishra, Arpit, Shelton, Patrick Mm, Sadilek, Martin, Hawkins, R David, Zheng, Ning, Roeder, Robert G, Chatterjee, Champak

“…The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric…”
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Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles by Blum, Jeremy S., Weller, Caroline E., Booth, Carmen J., Babar, Imran A., Liang, Xianping, Slack, Frank J., Saltzman, W. Mark

“…Primary squamous cell carcinoma of the vagina is an uncommon disease that often exhibits few symptoms before reaching an advanced stage. Topical intravaginal…”
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All About That Amide Bond: The 6th Chemical Protein Synthesis (CPS) Meeting by Weller, Caroline E., Chatterjee, Champak

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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS by Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro

“…The discovery of small-molecule inhibitors requires suitable binding pockets on protein surfaces. Proteins that lack this feature are considered undruggable…”
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Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery by Fields, Rachel J., Cheng, Christopher J., Quijano, Elias, Weller, Caroline, Kristofik, Nina, Duong, Nha, Hoimes, Christopher, Egan, Marie E., Saltzman, W. Mark

“…The use of biodegradable polymers provides a potentially safe and effective alternative to viral and liposomal vectors for the delivery of plasmid DNA to cells…”
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Abstract PR10: Tri-complex inhibitors of the oncogenic, GTP-bound form of KRASG12C overcome RTK-mediated escape mechanisms and drive tumor regressions in vivo by Schulze, Christopher J, Bermingham, Alun, Choy, Tiffany J, Cregg, James J, Kiss, Gert, Marquez, Abby, Reyes, Denise, Saldajeno-Concar, Mae, Weller, Caroline E, Whalen, Daniel M, Yang, Yu C, Koltun, Elena S, Nichols, Robert J, Singh, Mallika, Wildes, David, Gill, Adrian L, Hansen, Richard L, Kelsey, Steve, Goldsmith, Mark A, Smith, Jacqueline A.M.

“…RAS proteins are small GTPases that drive cell proliferation and survival when bound to GTP. Mutant RAS proteins are found in approximately one-third of human…”
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Abstract B080: Mutant-selective KRASG12D(ON) inhibitor suppresses proliferation in vitro and tumor growth in vivo of KrasG12D GEMM-derived PDAC organoids by Labrecque, Mark P., Jiang, Lingyan, Nasholm, Nicole, Nayak, Biswadeep, Yu, Xinxing, Song, Avian, Weller, Caroline, Evans, James W., Zafra, Maria Paz, Parsons, Marie, Menard, Marie, Dow, Lukas E., Jiang, Jingjing, Aronchik, Ida, Singh, Mallika

“…KRAS is the most frequently mutated oncogene in pancreatic ductal adenocarcinoma (PDAC), with KRASG12D driving initiation and progression of ~40% of tumors…”
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Rapid Semisynthesis of Acetylated and Sumoylated Histone Analogs by Dhall, A, Weller, C E, Chatterjee, C

“…The density and diversity of posttranslational modifications (PTMs) observed in histone proteins typically limit their purification to homogeneity from…”
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Abstract ND03: Discovery of RMC-9805, an oral, covalent tri-complex KRASG12D(ON) inhibitor by Knox, John E., Burnett, G. Leslie, Weller, Caroline, Jiang, Lingyan, Zhang, Dongyu, Vita, Nicole, Marquez, Abby, Seamon, Kyle J., Gould, Andrea, Menard, Marie, Quintana, Elsa, Chen, Zhe, Wang, Zhican, Wang, Zhengping, Koltun, Elena S., Singh, Malika, Jiang, Jingjing, Wildes, David, Smith, Jacqueline A.M., Gill, Adrian L.

“…RASG12D mutant cancers represent a significant unmet medical need with 55,000 new diagnoses annually in the US. The RASG12D mutation increases the abundance of…”
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