Search Results - "Welldon, Katie J"

Sclerostin is a locally acting regulator of late‐osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE‐ASARM‐dependent mechanism by Atkins, Gerald J, Rowe, Peter S, Lim, Hui P, Welldon, Katie J, Ormsby, Renee, Wijenayaka, Asiri R, Zelenchuk, Lesya, Evdokiou, Andreas, Findlay, David M

“…The identity of the cell type responsive to sclerostin, a negative regulator of bone mass, is unknown. Since sclerostin is expressed in vivo by…”
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Pro‐Inflammatory Cytokines TNF‐Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen‐Activated Protein Kinase (MAPK)‐Dependent Expression of Sclerostin in Human Osteoblasts by Vincent, Cristina, Findlay, David M, Welldon, Katie J, Wijenayaka, Asiri R, Zheng, Timothy S, Haynes, David R, Fazzalari, Nicola L, Evdokiou, Andreas, Atkins, Gerald J

“…We have recently shown that TNF‐related weak inducer of apoptosis (TWEAK) is a mediator of inflammatory bone remodeling. The aim of this study was to…”
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Metabolism of vitamin D3 in human osteoblasts: Evidence for autocrine and paracrine activities of 1α,25-dihydroxyvitamin D3 by Atkins, Gerald J, Anderson, Paul H, Findlay, David M, Welldon, Katie J, Vincent, Cristina, Zannettino, Andrew C.W, O'Loughlin, Peter D, Morris, Howard A

“…Abstract Circulating 1α,25-dihydroxyvitamin D3 (1,25D) derives from renal conversion of 25-hydroxyvitamin D3 (25D), by the 25D 1α-hydroxylase (CYP27B1). Blood…”
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Calcium induces pro-anabolic effects on human primary osteoblasts associated with acquisition of mature osteocyte markers by Welldon, Katie J., Findlay, David M., Evdokiou, Andreas, Ormsby, Renee T., Atkins, Gerald J.

“…•Calcium effects on human osteoblast mineralisation and differentiation were tested.•Calcium induced matrix mineralisation and osteoblast to osteocyte…”
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Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype by Welldon, Katie J., Atkins, Gerald J., Howie, Donald W., Findlay, David M.

“…Porous tantalum (Ta) has found application in orthopedics, although the interaction of human osteoblasts (HOB) with this material has not been reported. The…”
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The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles by Atkins, Gerald J, Welldon, Katie J, Holding, Christopher A, Haynes, David R, Howie, Donald W, Findlay, David M

“…Abstract Polyethylene (PE) wear particles are associated with the osteolysis seen in aseptic loosening that leads to orthopaedic implant failure. While cells…”
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Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium by Atkins, Gerald J., Kostakis, Panagiota, Welldon, Katie J., Vincent, Cristina, Findlay, David M., Zannettino, Andrew C.W.

“…While it has been assumed that osteoblasts in the human support osteoclast formation, in vitro evidence of this is currently lacking. We tested the ability of…”
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Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration by Zannettino, Andrew C W, Roubelakis, Maria, Welldon, Katie J, Jackson, Denise E, Simmons, Paul J, Bendall, Linda J, Henniker, Anthony, Harrison, Kate L, Niutta, Silvana, Bradstock, Kenneth F, Watt, Suzanne M

“…SHP-2 (Src homology phosphatase type-2) is essential for haematopoietic skeletal and vascular development. Thus the identification of its binding partners is…”
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Metabolism of vitamin D 3 in human osteoblasts: Evidence for autocrine and paracrine activities of 1α,25-dihydroxyvitamin D 3 by Atkins, Gerald J., Anderson, Paul H., Findlay, David M., Welldon, Katie J., Vincent, Cristina, Zannettino, Andrew C.W., O'Loughlin, Peter D., Morris, Howard A.

“…Circulating 1α,25-dihydroxyvitamin D 3 (1,25D) derives from renal conversion of 25-hydroxyvitamin D 3 (25D), by the 25D 1α-hydroxylase (CYP27B1). Blood 25D…”
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Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms by Atkins, Gerald J, Welldon, Katie J, Wijenayaka, Asiri R, Bonewald, Lynda F, Findlay, David M

“…The vitamin K family members phylloquinone (vitamin K1) and the menaquinones (vitamin K2) are under study for their roles in bone metabolism and as potential…”
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Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts by Vincent, Cristina, Findlay, David M, Welldon, Katie J, Wijenayaka, Asiri R, Zheng, Timothy S, Haynes, David R, Fazzalari, Nicola L, Evdokiou, Andreas, Atkins, Gerald J

“…We have recently shown that TNF-related weak inducer of apoptosis (TWEAK) is a mediator of inflammatory bone remodeling. The aim of this study was to…”
Get full text