Search Results - "Welker, Mark E."

Boron and Silicon-Substituted 1,3-Dienes and Dienophiles and Their Use in Diels-Alder Reactions by Welker, Mark E

“…Boron and silicon-substituted 1,3-dienes and boron and silicon-substituted alkenes and alkynes have been known for years and the last 10 years have seen a…”
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Ferrocenes as Building Blocks in Molecular Rectifiers and Diodes by Welker, Mark E

“…Ferrocenes have recently been reported as components of a number of molecular circuits. This short review covers reports of ferrocenes in molecular rectifiers…”
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Development of a Novel Oral Delivery Vehicle for Probiotics by Enck, Kevin, Banks, Surya, Yadav, Hariom, Welker, Mark E, Opara, Emmanuel C

“…There is a significant interest in effective oral drug delivery of therapeutic substances. For probiotics, there is a particular need for a delivery platform…”
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Preparation and Diels–Alder/Cross Coupling Reactions of New 2‑Boron-Substituted 1,3-Dienes by Wang, Liqiong, Welker, Mark E

“…Several new 2-boron substituted dienes have been prepared and characterized. Their reactivity in Diels–Alder reactions has been examined and the boron…”
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Synthesis and PI3 Kinase Inhibition Activity of a Wortmannin-Leucine Derivative by Cantrell, William, Huang, Yue, Menchaca, Antonio A, Kulik, George, Welker, Mark E

“…Wortmannin is a potent covalent inhibitor of PI3K that shows substantial in vivo toxicity and thus is unsuitable for systemic therapeutic applications. One…”
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Preparation and Reaction Chemistry of Novel Silicon-Substituted 1,3-Dienes by Choudhury, Partha P, Welker, Mark E

“…2-Silicon-substituted 1,3-dienes containing non transferrable groups known to promote transmetallation were prepared by Grignard chemistry and enyne…”
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Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine by Banks, Surya R., Yoo, Kyung Min, Welker, Mark E.

“…A series of small molecules containing polar aromatic substituents and alkynes have been synthesized. One–pot preparations of polar aromatic molecules…”
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Synthesis and PI3 Kinase Inhibition Activity of Some Novel Trisubstituted Morpholinopyrimidines by Wright, Emily W, Nelson, Jr, Ronald A, Karpova, Yelena, Kulik, George, Welker, Mark E

“…A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One of…”
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Synthesis and PI 3-Kinase Inhibition Activity of Some Novel 2,4,6-Trisubstituted 1,3,5-Triazines by Nelson, Jr, Ronald A, Schronce, Taylor, Huang, Yue, Albugami, Alanoud, Kulik, George, Welker, Mark E

“…A number of new trisubstituted triazine phosphatidylinositol 3-kinase (PI3K) inhibitors were prepared via a three-step procedure utilizing sequential…”
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Chemical Modification of Alginate for Controlled Oral Drug Delivery by Banks, Surya R, Enck, Kevin, Wright, Marcus, Opara, Emmanuel C, Welker, Mark E

“…Here, we report two methods that chemically modify alginate to achieve neutral–basic pH sensitivity of the resultant hydrogel. The first method involves direct…”
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Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors by Welker, Mark E., Kulik, George

“…This review focuses on the syntheses of PI3K/Akt/mTOR inhibitors that have been reported outside of the patent literature in the last 5years but is largely…”
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The Stark Effect: A Tool for the Design of High-Performance Molecular Rectifiers by Sullivan, Ryan P., Morningstar, John T., Castellanos-Trejo, Eduardo, Welker, Mark E., Jurchescu, Oana D.

“…Molecular electronic devices offer a path to the miniaturization of electronic circuits and could potentially facilitate novel functionalities that can be…”
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Synthesis of sulfur and silicon SAM precursors for molecular electronics applications by Welker, Mark E.

“…This review largely covers the synthesis of sulfur and silicon containing small molecules that have subsequently been used as components of a number of…”
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Recent advances in syntheses and reaction chemistry of boron and silicon substituted 1,3-dienes by Welker, Mark E.

“…[Display omitted]…”
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Preparation and Diels-Alder/cross coupling reactions of a 2-diethanolaminoboron-substituted 1,3-diene by Wang, Liqiong, Day, Cynthia S, Wright, Marcus W, Welker, Mark E

“…A 2-diethanolamine boronyl substituted 1,3-diene has been synthesized in high yield and characterized spectroscopically as well as by X-ray crystallography…”
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Molecular Rectifiers on Silicon: High Performance by Enhancing Top-Electrode/Molecule Coupling by Lamport, Zachary A, Broadnax, Angela D, Scharmann, Ben, Bradford, Robert W, DelaCourt, Andrew, Meyer, Noah, Li, Hui, Geyer, Scott M, Thonhauser, Timo, Welker, Mark E, Jurchescu, Oana D

“…One of the simplest molecular-scale electronic devices is the molecular rectifier. In spite of considerable efforts aimed at understanding structure–property…”
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Synthesis and Characterization of a Novel Prostate Cancer-Targeted Phosphatidylinositol-3-kinase Inhibitor Prodrug by Baiz, Daniele, Pinder, Tanya A, Hassan, Sazzad, Karpova, Yelena, Salsbury, Freddie, Welker, Mark E, Kulik, George

“…The phosphatidylinositol-3-kinase/Akt (PI3K/Akt) pathway is constitutively activated in a substantial proportion of prostate tumors and is considered a key…”
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Intermolecular charge transfer enhances the performance of molecular rectifiers by Sullivan, Ryan P., Morningstar, John T., Castellanos-Trejo, Eduardo, Bradford, Robert W., Hofstetter, Yvonne J., Vaynzof, Yana, Welker, Mark E., Jurchescu, Oana D.

“…Molecular-scale diodes made from self-assembled monolayers (SAMs) could complement silicon-based technologies with smaller, cheaper, and more versatile…”
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Fluorinated benzalkylsilane molecular rectifiers by Lamport, Zachary A., Broadnax, Angela D., Harrison, David, Barth, Katrina J., Mendenhall, Lee, Hamilton, Clayton T., Guthold, Martin, Thonhauser, Timo, Welker, Mark E., Jurchescu, Oana D.

“…We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) – (EtO) 3 Si(CH 2 ) n N = CHPhX where n = 3…”
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Ruthenium carbenes as catalysts in stereoselective ene–yne metathesis/Diels–Alder and ene–yne metathesis/Diels–Alder/cross coupling multicomponent reactions by Junker, Christopher S., Welker, Mark E.

“…An ene–yne cross metathesis of silyl substituted alkynes and alkenes followed by a Diels–Alder reaction of the metathesis product 2-silyl-1,3-dienes has been…”
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