Search Results - "Welhaven, Hope D."

Effects of mechanical stimulation on metabolomic profiles of SW1353 chondrocytes: shear and compression by Welhaven, Hope D, McCutchen, Carley N, June, Ronald K

“…Mechanotransduction is a biological phenomenon where mechanical stimuli are converted to biochemical responses. A model system for studying mechanotransduction…”
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Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage by Welhaven, Hope D, Welfley, Avery H, Brahmachary, Priyanka, Bergstrom, Annika R, Houske, Eden, Glimm, Matthew, Bothner, Brian, Hahn, Alyssa K, June, Ronald K

“…Osteoarthritis (OA) is a chronic joint disease with heterogenous metabolic pathology. To gain insight into OA-related metabolism, metabolite extracts from…”
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The Cortical Bone Metabolome of C57BL/6J Mice Is Sexually Dimorphic by Welhaven, Hope D., Vahidi, Ghazal, Walk, Seth T., Bothner, Brian, Martin, Stephen A., Heveran, Chelsea M., June, Ronald K.

“…ABSTRACT Cortical bone quality, which is sexually dimorphic, depends on bone turnover and therefore on the activities of remodeling bone cells. However, sex…”
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Osteoarthritis Year in Review 2024: Molecular biomarkers of osteoarthritis by Welhaven, Hope D., Welfley, Avery H., June, Ronald K.

“…To provide a comprehensive and insightful summary of studies on molecular biomarkers at the gene, protein, and metabolite levels across different sample types…”
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Metabolomic profiles of cartilage and bone reflect tissue type, radiography-confirmed osteoarthritis, and spatial location within the joint by Welhaven, Hope D., Viles, Ethan, Starke, Jenna, Wallace, Cameron, Bothner, Brian, June, Ronald K., Hahn, Alyssa K.

“…Osteoarthritis is the most common chronic joint disease, characterized by the abnormal remodeling of joint tissues including articular cartilage and…”
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Metabolic phenotypes reflect patient sex and injury status: A cross-sectional analysis of human synovial fluid by Welhaven, Hope D., Welfley, Avery H., Pershad, Prayag, Satalich, James, O'Connell, Robert, Bothner, Brian, Vap, Alexander R., June, Ronald K.

“…Osteoarthritis is a heterogeneous disease. The objective was to compare differences in underlying cellular mechanisms and endogenous repair pathways between…”
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Germ‐Free C57BL/6 Mice Have Increased Bone Mass and Altered Matrix Properties but Not Decreased Bone Fracture Resistance by Vahidi, Ghazal, Moody, Maya, Welhaven, Hope D., Davidson, Leah, Rezaee, Taraneh, Behzad, Ramina, Karim, Lamya, Roggenbeck, Barbara A., Walk, Seth T., Martin, Stephen A., June, Ronald K., Heveran, Chelsea M.

“…ABSTRACT The gut microbiome impacts bone mass, which implies a disruption to bone homeostasis. However, it is not yet clear how the gut microbiome affects the…”
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Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease by Houske, Eden A, Glimm, Matthew G, Bergstrom, Annika R, Slipher, Sally K, Welhaven, Hope D, Greenwood, Mark C, Linse, Greta M, June, Ronald K, Yu, Alan S L, Wallace, Darren P, Hahn, Alyssa K

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of numerous fluid-filled cysts that lead to progressive loss of…”
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The microbiome mediates epiphyseal bone loss and metabolomic changes after acute joint trauma in mice by Hahn, A.K., Wallace, C.W., Welhaven, H.D., Brooks, E., McAlpine, M., Christiansen, B.A., Walk, S.T., June, R.K.

“…To compare the early responses to joint injury in conventional and germ-free mice. Post-traumatic osteoarthritis (PTOA) was induced using a non-invasive…”
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