Search Results - "Welgus, Howard"

Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration by Mohan, Royce, Chintala, Shravan K., Jung, Jae Chang, Villar, Winston V.L., McCabe, Frank, Russo, Laoti A., Lee, Yunhee, McCarthy, Brendan E., Wollenberg, Kurt R., Jester, James V., Wang, Min, Welgus, Howard G., Shipley, J. Michael, Senior, Robert M., Fini, M. Elizabeth

“…We studied the role of the matrix metalloproteinase gelatinase B (gelB; MMP-9) in epithelial regeneration using the gelB-deficient mouse. We report the novel…”
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Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization by Cornelius, Lynn A, Nehring, Leslie C, Harding, Elizabeth, Bolanowski, Mark, Welgus, Howard G, Kobayashi, Dale K, Pierce, Richard A, Shapiro, Steven D

“…Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell proliferation and metastatic tumor cell growth. Recently, the…”
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Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis by NIKKARI, S. T, O'BRIEN, K. D, FERGUSON, M, HATSUKAMI, T, WELGUS, H. G, ALPERS, C. E, CLOWES, A. W

“…In human atherosclerosis, most clinical events occur when plaque integrity is compromised and hemorrhage and thrombosis result. One mechanism for this might be…”
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The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix by Pilcher, Brian K., Dumin, Jo Ann, Sudbeck, Barry D., Krane, Stephen M., Welgus, Howard G., Parks, William C.

“…We have shown in a variety of human wounds that collagenase-1 (MMP-1), a matrix metalloproteinase that cleaves fibrillar type I collagen, is invariably…”
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Chlamydia pneumoniae Proteins Induce Secretion of the 92-kDa Gelatinase by Human Monocyte– Derived Macrophages by Vehmaan-Kreula, Pirjo, Puolakkainen, Mirja, Sarvas, Matti, Welgus, Howard G, Kovanen, Petri T

“…Chlamydia pneumoniae, an intracellular Gram-negative respiratory bacterium, and macrophages are present in inflammatory tissue sites such as atherosclerotic…”
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Initiation of Osteoclast Bone Resorption by Interstitial Collagenase by Holliday, L. Shannon, Welgus, Howard G., Fliszar, Catherine J., Veith, G. Michael, Jeffrey, John J., Gluck, Stephen L.

“…Osteoclasts form an acidic compartment at their attachment site in which bone demineralization and matrix degradation occur. Although both the cysteine…”
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Human Lung Tissue Macrophages, but not Alveolar Macrophages, Express Matrix Metalloproteinases after Direct Contact with Activated T Lymphocytes by Ferrari-Lacraz, Sylvie, Nicod, Laurent P, Chicheportiche, Rachel, Welgus, Howard G, Dayer, Jean-Michel

“…Human alveolar macrophages (AM) and lung tissue macrophages (LTM) have a distinct localization in the cellular environment. We studied their response to direct…”
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis by Lebwohl, Mark G, Papp, Kim A, Stein Gold, Linda, Gooderham, Melinda J, Kircik, Leon H, Draelos, Zoe D, Kempers, Steven E, Zirwas, Mathew, Smith, Kathleen, Osborne, David W, Trotman, Marie-Louise, Navale, Lynn, Merritt, Charlotte, Berk, David R, Welgus, Howard

“…A cream formulation of the phosphodiesterase type 4 inhibitor roflumilast, in two concentrations, led to higher percentages of patients with clearance or…”
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Matrix Metalloproteinase Deficiencies Affect Contact Hypersensitivity: Stromelysin-1 Deficiency Prevents the Response and Gelatinase B Deficiency Prolongs the Response by Wang, Min, Qin, Xuejin, Mudgett, John S., Ferguson, Thomas A., Senior, Robert M., Welgus, Howard G.

“…Matrix metalloproteinases (MMPs) are expressed by T cells and macrophages, but there is a paucity of evidence for their role in immune responses. We have…”
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The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases by Shipley, J. Michael, Doyle, Glenn A.R., Fliszar, Catherine J., Ye, Qi-Zhuang, Johnson, Linda L., Shapiro, Steven D., Welgus, Howard G., Senior, Robert M.

“…Several matrix metalloproteinases, including the 92-kDa and 72-kDa gelatinases, macrophage metalloelastase (MME), and matrilysin degrade insoluble elastin…”
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Induction and Repression of Collagenase-1 by Keratinocytes Is Controlled by Distinct Components of Different Extracellular Matrix Compartments by Sudbeck, Barry D., Pilcher, Brian K., Welgus, Howard G., Parks, William C.

“…In all forms of cutaneous wounds, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is invariably expressed by basal keratinocytes migrating over the dermal…”
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15309 ARQ-151, roflumilast cream, improved psoriasis in phase 2a study by Papp, Kim A., Gooderham, Melinda, Droege, Michael, Merritt, Charlotte, Osborne, David W., Berk, David R., Thurston, Archie W., Smith, Valerie H., Welgus, Howard

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The Safety and Efficacy of Roflumilast Cream 0.15% and 0.05% in Patients With Atopic Dermatitis: Randomized, Double-Blind, Phase 2 Proof of Concept Study by Gooderham, Melinda, Kircik, Leon, Zirwas, Matthew, Lee, Mark, Kempers, Steven, Draelos, Zoe, Ferris, Laura, Jones, Terry, Saint-Cyr Proulx, Etienne, Bissonnette, Robert, Bhatia, Neal, Koppel, Robert, Guenthner, Scott, Eads, Kimmie, Welgus, Howard, Merritt, Charlotte, Elias, Meg, Navale, Lynn, Higham, Robert, Droege, Michael, Berk, David

“…Patients with atopic dermatitis (AD) need safe and effective topical treatments. To assess safety and efficacy of roflumilast cream in patients with mild to…”
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Mechanisms of Hepatocyte Growth Factor Stimulation of Keratinocyte Metalloproteinase Production by Dunsmore, S E, Rubin, J S, Kovacs, S O, Chedid, M, Parks, W C, Welgus, H G

“…Matrix metalloproteinases participate in normal physiologic processes; however, their overproduction has been associated with connective tissue destruction in…”
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Matrix Metalloproteinases-3, -7, and -12, but Not -9, Reduce High Density Lipoprotein-induced Cholesterol Efflux from Human Macrophage Foam Cells by Truncation of the Carboxyl Terminus of Apolipoprotein A-I by Lindstedt, Leena, Saarinen, Juhani, Kalkkinen, Nisse, Welgus, Howard, Kovanen, Petri T.

“…Matrix metalloproteinases (MMPs) have been suggested to function in remodeling of the arterial wall, but no information is available on their possible role in…”
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Expression of 92-kDa Type IV Collagenase mRNA by Eosinophils Associated with Basal Cell Carcinoma by Stähle-Bäckdahl, Mona, Sudbeck, Barry D, Eisen, Arthur Z, Welgus, Howard G, Parks, William C

“…Metalloproteinases are thought to be important for tumor invasion and metastasis. We used in situ hybridization with 35S-labeled cRNA probes to localize sites…”
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Induction of Macrophage Matrix Metalloproteinase Biosynthesis by Surfactant Protein D by Trask, Barbara Crippes, Malone, Mark J., Lum, Esther H., Welgus, Howard G., Crouch, Erika C., Shapiro, Steven D.

“…Recent studies strongly suggest that surfactant protein D (SP-D) plays important roles in pulmonary host defense and the regulation of immune and inflammatory…”
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Keratinocyte Collagenase-1 Expression Requires an Epidermal Growth Factor Receptor Autocrine Mechanism by Pilcher, B K, Dumin, J, Schwartz, M J, Mast, B A, Schultz, G S, Parks, W C, Welgus, H G

“…In response to cutaneous injury, expression of collagenase-1 is induced in keratinocytes via α 2 β 1 contact with native type I collagen, and enzyme activity…”
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Broad‐spectrum matrix metalloproteinase inhibitor marimastat–induced musculoskeletal side effects in rats by Renkiewicz, Richard, Qiu, Luping, Lesch, Charles, Sun, Xin, Devalaraja, Radhika, Cody, Theresa, Kaldjian, Eric, Welgus, Howard, Baragi, Vijaykumar

“…Objective To characterize the clinical and histopathologic changes in a rat model of broad‐spectrum matrix metalloproteinase (MMP)–induced musculoskeletal…”
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Matrix Metalloproteinases Cleave Tissue Factor Pathway Inhibitor by Belaaouaj, Abderr azzaq, Li, Anguo, Wun, Tze-Chein, Welgus, Howard G., Shapiro, Steven D.

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