Search Results - "Welch, George N"

Homocysteine and Atherothrombosis by Welch, George N, Loscalzo, Joseph

“…In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease. 1 He reported autopsy evidence of…”
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Stimulation of endothelial nitric oxide production by homocyst(e)ine by Upchurch, Gilbert R, Welch, George N, Fabian, Attila J, Pigazzi, Alessio, Keaney, John F, Loscalzo, Joseph

“…Hyperhomocyst(e)inemia, characterized by accelerated atherosclerosis, is believed to induce endothelial cell injury and promote atherothrombosis by supporting…”
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Homocysteine, EDRF, and endothelial function by Upchurch, Jr, G R, Welch, G N, Loscalzo, J

“…Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its…”
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Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase by Upchurch, Gilbert R., Welch, George N., Fabian, Attila J., Freedman, Jane E., Johnson, Joseph L., Keaney, John F., Loscalzo, Joseph

“…Hyperhomocyst(e)inemia is believed to injure endothelial cells in vivo through a number of mechanisms, including the generation of hydrogen peroxide (H2O2)…”
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High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells by UPCHURCH, G. R, WELCH, G. N, FREEDMAN, J. E, FABIAN, A. J, PIGAZZI, A, SCRIBNER, A. M, ALPERT, C. S, KEANEY, J. F, LOSCALZO, J

“…Abrupt cessation of heparin therapy can lead to a recrudescence of thrombosis and acute ischemia. Endothelial NO is an important endogenous inhibitor of…”
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Homocysteine, oxidative stress, and vascular disease by Welch, G N, Upchurch, Jr, G R, Loscalzo, J

“…First recognized in patients with rare inborn errors of metabolism, the association of elevated plasma homocysteine concentrations with atherosclerosis and…”
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Hyperhomocyst(e)inemia and Atherothrombosisa by WELCH, GEORGE N., UPCHURCH, GILBERT, LOSCALZO, JOSEPH

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Heparin reacts with and inactivates nitric oxide by Upchurch, Jr, G R, Goodman, D G, Willoughby, S R, Zhang, Y Y, Welch, G N, Freedman, J E, Ye, S, Costello, C E, Loscalzo, J

“…Although heparin is a well-known anticoagulant, in some cases it promotes a prothrombotic state and does so through both antibody-dependent and…”
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The Vascular Biology of S-Nitrosothiols, Nitrosated Derivatives of Thiols by Upchurch, Gilbert R, Welch, George N, Loscalzo, Joseph

“…Nitric oxide (NO) is a simple heterodiatomic molecule with a broad range of biologic actions. In the cardiovascular system NO serves as an…”
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Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide by Marks, D S, Vita, J A, Folts, J D, Keaney, Jr, J F, Welch, G N, Loscalzo, J

“…Endothelium-derived relaxing factor is important for vascular homeostasis and possesses qualities that may modulate vascular injury, including vasodilation,…”
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In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols by Scharfstein, J S, Keaney, Jr, J F, Slivka, A, Welch, G N, Vita, J A, Stamler, J S, Loscalzo, J

“…Plasma albumin reacts with nitric oxide (NO) to form the bioactive adduct, S-nitroso-albumin (S-NO-albumin). The limited intracellular access of S-NO-albumin…”
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Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols by Freedman, J E, Frei, B, Welch, G N, Loscalzo, J

“…GSH peroxidase (Px) catalyzes the reduction of lipid hydroperoxides (LOOH), known metabolic products of platelets and vascular cells. Because interactions…”
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Hyperhomocyst(e)inemia and Atherothrombosis by WELCH, GEORGE N., UPCHURCH JR, GILBERT, LOSCALZO, JOSEPH

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Homocyst(e)ine and Atherothrombosis by Lawson, Matthew F, van Guldener, Coen, Donker, Ab J.M, Stehouwer, Coen D.A, Nath, Karl A, Welch, George N, Loscalzo, Joseph

“…To the Editor: The review article “Homocysteine and Atherothrombosis” by Welch and Loscalzo (April 9 issue) 1 was very interesting, and it conclusively showed…”
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S-nitrosothiol detection by Welch, G N, Upchurch, Jr, G R, Loscalzo, J

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407-3 Glutathione Peroxidase Prevents the Inactivation of Nitric Oxide and Restores the Inhibition of Platelet Function by S-Nitrosothiols by Freedman, Jane E., Frei, Balz, Welch, George N., Loscalzo, Joseph

“…The interaction of nitric oxide (NO) with reactive oxygen species in the vasculature can inactivate NO leading to potentially adverse vascular consequences…”
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Heparin reverses the antiplatelet effect of nitric oxide by Upchurch, Gilbert R., Freedman, Jane E., Zhang, Yingyi, Welch, George N., Loscalzo, Joseph

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Homocyst(e)ine decreases cell redox potential in vascular smooth muscle cells by Welch, George N., Upchurch, Gilbert R., Keaney, John F., Loscalzo, Joseph

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Effect of heparin on fibrinolytic activity and platelet function in vivo by Upchurch, G R, Valeri, C R, Khuri, S F, Rohrer, M J, Welch, G N, MacGregor, H, Ragno, G, Francis, S, Rodino, L J, Michelson, A D, Loscalzo, J

“…Heparin, a polyanionic glycosaminoglycan, is used routinely before the induction of cardiopulmonary bypass. Earlier observations in our laboratory suggested…”
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S-nitrosothiols: chemistry, biochemistry, and biological actions by Upchurch, Jr, G R, Welch, G N, Loscalzo, J

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