Search Results - "Welc, Steven S."

Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis by Tidball, James G., Flores, Ivan, Welc, Steven S., Wehling-Henricks, Michelle, Ochi, Eisuke

“…Skeletal muscle regeneration that follows acute injury is strongly influenced by interactions with immune cells that invade and proliferate in the damaged…”
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The regulation of interleukin‐6 implicates skeletal muscle as an integrative stress sensor and endocrine organ by Welc, Steven S., Clanton, Thomas L.

“…New findings •  What is the topic of this review? This review discusses the regulation of the interleukin‐6 (IL‐6) gene and how it is uniquely set up to…”
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Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy by Welc, Steven S., Flores, Ivan, Wehling-Henricks, Michelle, Ramos, Julian, Wang, Ying, Bertoni, Carmen, Tidball, James G.

“…Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of…”
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Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway by Wehling-Henricks, Michelle, Welc, Steven S, Samengo, Guiseppina, Rinaldi, Chiara, Lindsey, Catherine, Wang, Ying, Lee, Jeongyoon, Kuro-O, Makoto, Tidball, James G

“…Abstract Duchenne muscular dystrophy (DMD) is a muscle wasting disease in which inflammation influences the severity of pathology. We found that the onset of…”
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Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes by Sakamoto, Eijiro, Kitase, Yukiko, Fitt, Alexander J., Zhu, Zewu, Awad, Kamal, Brotto, Marco, White, Kenneth E., Welc, Steven S., Bergwitz, Clemens, Bonewald, Lynda F.

“…With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. Exercise in mice increased fibroblast growth factor 23…”
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Heat stroke activates a stress-induced cytokine response in skeletal muscle by Welc, Steven S, Clanton, Thomas L, Dineen, Shauna M, Leon, Lisa R

“…Heat stroke (HS) induces a rapid elevation in a number of circulating cytokines. This is often attributed to the stimulatory effects of endotoxin, released…”
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Protection of intestinal injury during heat stroke in mice by interleukin‐6 pretreatment by Phillips, Neil A., Welc, Steven S., Wallet, Shannon M., King, Michelle A., Clanton, Thomas L.

“…Key points Heat stroke afflicts thousands of humans each year, worldwide. The immune system responds to hyperthermia exposure resulting in heat stroke by…”
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Skeletal muscle interleukin-6 regulation in hyperthermia by Welc, Steven S, Judge, Andrew R, Clanton, Thomas L

“…We previously reported that IL-6 production is acutely elevated in skeletal muscles exposed to ≥41°C, but the regulatory pathways are poorly understood. The…”
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The Impact of Hyperthermia on Receptor-Mediated Interleukin-6 Regulation in Mouse Skeletal Muscle by Welc, Steven S, Morse, Deborah A, Mattingly, Alex J, Laitano, Orlando, King, Michelle A, Clanton, Thomas L

“…In inflammatory cells, hyperthermia inhibits lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) gene expression and protein secretion. Since hyperthermia…”
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Hyperthermia increases interleukin-6 in mouse skeletal muscle by Welc, Steven S, Phillips, Neil A, Oca-Cossio, Jose, Wallet, Shannon M, Chen, Daniel L, Clanton, Thomas L

“…Skeletal muscles produce and contribute to circulating levels of IL-6 during exercise. However, when core temperature is reduced, the response is attenuated…”
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Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy by Chadwick, Jessica A, Swager, Sarah A, Lowe, Jeovanna, Welc, Steven S, Tidball, James G, Gomez-Sanchez, Celso E, Gomez-Sanchez, Elise P, Rafael-Fortney, Jill A

“…FDA-approved mineralocorticoid receptor (MR) antagonists are used to treat heart failure. We have recently demonstrated efficacy of MR antagonists for skeletal…”
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Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake by McMillin, Shawna L, Evans, Parker L, Taylor, William M, Weyrauch, Luke A, Sermersheim, Tyler J, Welc, Steven S, Heitmeier, Monique R, Hresko, Richard C, Hruz, Paul W, Koumanov, Francoise, Holman, Geoffrey D, Abel, E Dale, Witczak, Carol A

“…Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated…”
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Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia by Wang, Ying, Wehling-Henricks, Michelle, Welc, Steven S., Fisher, Allison L., Zuo, Qun, Tidball, James G.

“…ABSTRACT Aging is associated with diminished muscle mass, reductions in muscle stem cell functions, and increased muscle fibrosis. The immune system,…”
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Myeloid cell‐derived tumor necrosis factor‐alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers by Wang, Ying, Welc, Steven S., Wehling‐Henricks, Michelle, Tidball, James G.

“…Sarcopenia is age‐related muscle wasting that lacks effective therapeutic interventions. We found that systemic ablation of tumor necrosis factor‐α (TNF‐α)…”
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Myeloid cell-mediated targeting of LIF to dystrophic muscle causes transient increases in muscle fiber lesions by disrupting the recruitment and dispersion of macrophages in muscle by Flores, Ivan, Welc, Steven S, Wehling-Henricks, Michelle, Tidball, James G

“…Abstract Leukemia inhibitory factor (LIF) can influence development by increasing cell proliferation and inhibiting differentiation. Because of its potency for…”
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Differential Effects of Myeloid Cell PPARδ and IL-10 in Regulating Macrophage Recruitment, Phenotype, and Regeneration following Acute Muscle Injury by Welc, Steven S, Wehling-Henricks, Michelle, Antoun, Jacqueline, Ha, Tracey T, Tous, Isabella, Tidball, James G

“…Changes in macrophage phenotype in injured muscle profoundly influence regeneration. In particular, the shift of macrophages from a proinflammatory (M1 biased)…”
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Macrophage-Derived IGF-1 Is a Potent Coordinator of Myogenesis and Inflammation in Regenerating Muscle by Tidball, James G, Welc, Steven S

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Myeloid cell‐specific mutation of Spi1 selectively reduces M2‐biased macrophage numbers in skeletal muscle, reduces age‐related muscle fibrosis and prevents sarcopenia by Wang, Ying, Welc, Steven S., Wehling‐Henricks, Michelle, Kong, Ying, Thomas, Connor, Montecino‐Rodriguez, Enca, Dorshkind, Kenneth, Tidball, James G.

“…Intramuscular macrophages play key regulatory roles in determining the response of skeletal muscle to injury and disease. Recent investigations showed that the…”
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Functional cardiac consequences of β-adrenergic stress-induced injury in a model of Duchenne muscular dystrophy by Earl, Conner C., Javier, Areli J., Richards, Alyssa M., Markham, Larry W., Goergen, Craig J., Welc, Steven S.

“…ABSTRACT Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD); however, in the mdx mouse model of DMD, the cardiac phenotype…”
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Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy by Wehling-Henricks, Michelle, Li, Zhenzhi, Lindsey, Catherine, Wang, Ying, Welc, Steven S, Ramos, Julian N, Khanlou, Négar, Kuro-O, Makoto, Tidball, James G

“…Duchenne muscular dystrophy (DMD) is a lethal muscle disease involving progressive loss of muscle regenerative capacity and increased fibrosis. We tested…”
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