Search Results - "Welburn, Julie P. I."

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations by Attard, Thomas J, Welburn, Julie P I, Marsh, Joseph A

“…Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β…”
Get full text

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch by Talapatra, Sandeep K, Harker, Bethany, Welburn, Julie P I

“…The precise regulation of microtubule dynamics is essential during cell division. The kinesin-13 motor protein MCAK is a potent microtubule depolymerase. The…”
Get full text

A circle of life: platelet and megakaryocyte cytoskeleton dynamics in health and disease by Liu, Haonan, Welburn, Julie P I

“…Platelets are blood cells derived from megakaryocytes that play a central role in regulating haemostasis and vascular integrity. The microtubule cytoskeleton…”
Get full text

Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning by McHugh, Toni, Gluszek, Agata A, Welburn, Julie P I

“…Mitotic spindle positioning specifies the plane of cell division during anaphase. Spindle orientation and positioning are therefore critical to ensure…”
Get full text

How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A by Welburn, Julie P.I., Tucker, Julie A., Johnson, Tim, Lindert, Lisa, Morgan, Marc, Willis, Antony, Noble, Martin E.M., Endicott, Jane A.

“…Inhibition of cyclin-dependent kinase 1 (CDK1) activity by Tyr-15 phosphorylation directly regulates entry into mitosis and is an important element in the…”
Get full text

The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle by Welburn, Julie P I, Cheeseman, Iain M

“…Microtubule dynamics are essential throughout mitosis to ensure correct chromosome segregation. Microtubule depolymerization is controlled in part by…”
Get full text

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility by Welburn, Julie P.I., Grishchuk, Ekaterina L., Backer, Chelsea B., Wilson-Kubalek, Elizabeth M., Yates, John R., Cheeseman, Iain M.

“…Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to drive chromosome movement. In…”
Get full text

Length-dependent anisotropic scaling of spindle shape by Young, Sarah, Besson, Sébastien, Welburn, Julie P I

“…Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory…”
Get full text

Reconstitution of an active human CENP-E motor by Craske, Benjamin, Legal, Thibault, Welburn, Julie P I

“…CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux…”
Get full text

Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes by Gigant, Emmanuelle, Stefanutti, Marine, Laband, Kimberley, Gluszek-Kustusz, Agata, Edwards, Frances, Lacroix, Benjamin, Maton, Gilliane, Canman, Julie C, Welburn, Julie P I, Dumont, Julien

“…In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation - essential to prevent miscarriage or developmental…”
Get full text

Molecular architecture of the Dam1 complex–microtubule interaction by Legal, Thibault, Zou, Juan, Sochaj, Alicja, Rappsilber, Juri, Welburn, Julie P. I.

“…Mitosis is a highly regulated process that allows the equal distribution of the genetic material to the daughter cells. Chromosome segregation requires the…”
Get full text

Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms by Nogales, Eva, Ramey, Vincent H, Westermann, Stefan, Barnes, Georjana, Wang, Hong-Wei, Nakajima, Yuko, Drubin, David G, Leschziner, Andres E, Welburn, Julie P I

“…The Dam1 kinetochore complex is essential for chromosome segregation in budding yeast. This ten-protein complex self-assembles around microtubules, forming…”
Get full text

Mechanisms of Mitotic Kinase Regulation: A Structural Perspective by Welburn, Julie P I, Jeyaprakash, A Arockia

“…Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome…”
Get full text

Potent microtubule-depolymerizing activity of a mitotic Kif18b-MCAK-EB network by McHugh, Toni, Welburn, Julie P I

“…The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13…”
Get full text

Leaving no-one behind: how CENP-E facilitates chromosome alignment by Craske, Benjamin, Welburn, Julie P I

“…Chromosome alignment and biorientation is essential for mitotic progression and genomic stability. Most chromosomes align at the spindle equator in a…”
Get more information

The role of protein complexes in human genetic disease by Bergendahl, L. Therese, Gerasimavicius, Lukas, Miles, Jamilla, Macdonald, Lewis, Wells, Jonathan N., Welburn, Julie P. I., Marsh, Joseph A.

“…Many human genetic disorders are caused by mutations in protein‐coding regions of DNA. Taking protein structure into account has therefore provided key insight…”
Get full text

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment by Legal, Thibault, Hayward, Daniel, Gluszek-Kustusz, Agata, Blackburn, Elizabeth A, Spanos, Christos, Rappsilber, Juri, Gruneberg, Ulrike, Welburn, Julie P I

“…During cell division, misaligned chromosomes are captured and aligned by motors before their segregation. The CENP-E motor is recruited to polar unattached…”
Get full text

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface by Welburn, Julie P.I., Vleugel, Mathijs, Liu, Dan, Yates, John R., Lampson, Michael A., Fukagawa, Tatsuo, Cheeseman, Iain M.

“…Accurate chromosome segregation requires carefully regulated interactions between kinetochores and microtubules, but how plasticity is achieved to correct…”
Get full text

A rapid computational approach identifies SPICE1 as an Aurora kinase substrate by Deretic, Jovana, Kerr, Alastair, Welburn, Julie P I

“…Aurora kinases play a major role in mitosis by regulating diverse substrates. Defining their critical downstream targets is important in understanding Aurora…”
Get full text

The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation by McHugh, Toni, Zou, Juan, Volkov, Vladimir A, Bertin, Aurélie, Talapatra, Sandeep K, Rappsilber, Juri, Dogterom, Marileen, Welburn, Julie P I

“…Kinesin-13 motors regulate precise microtubule dynamics and limit microtubule length throughout metazoans by depolymerizing microtubule ends. Recently, the…”
Get full text