Search Results - "Wekstein, D. R."

Brain structural alterations before mild cognitive impairment by SMITH, C. D, CHEBROLU, H, WEKSTEIN, D. R, SCHMITT, F. A, JICHA, G. A, COOPER, G, MARKESBERY, W. R

“…To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease…”
Get full text

Alzheimer Neuropathologic Alterations in Aged Cognitively Normal Subjects by Davis, D G, Schmitt, F A, Wekstein, D R, Markesbery, W R

“…The histopathologic changes distinguishing early Alzheimer disease (AD) from normal or pathologic aging arc not clearly defined. This report describes the…”
Get full text

Preclinical AD revisited : Neuropathology of cognitively normal older adults by SCHMITT, F. A, DAVIS, D. G, WEKSTEIN, D. R, SMITH, C. D, ASHFORD, J. W, MARKESBERY, W. R

“…To classify neuropathologic alterations in the brains of nondemented older adults using current sets of criteria for AD. AD neuropathologic alterations are…”
Get full text

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease by Poleggi, A., Bizzarro, A., Acciarri, A., Antuono, P., Bagnoli, S., Cellini, E., Forno, G. Dal, Giannattasio, C., Lauria, A., Matera, M. G., Nacmias, B., Puopolo, M., Seripa, D., Sorbi, S., Wekstein, D. R., Pocchiari, M., Masullo, C.

“…Codon 129 polymorphism of the prion protein gene represents a major genetic risk factor for Creutzfeldt‐Jakob disease (CJD). Both CJD and Alzheimer’s disease…”
Get full text

Laboratory values in fit aging individuals--sexagenarians through centenarians by Tietz, N W, Shuey, D F, Wekstein, D R

“…We determined approximately 15,000 laboratory values in 236 individuals between the ages of 60 and 90 y, 22 individuals between 90 and 99 y, and 69 individuals…”
Get more information

Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism by SERIPA, D, MATERA, M. G, DAL FORNO, G, FAZIO, V. M, D'ANDREA, R. P, GRAVINA, C, MASULLO, C, DANIELE, A, BIZZARRO, A, RINALDI, M, ANTUONO, P, WEKSTEIN, D. R

“…The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of…”
Get full text

Pharmacokinetics, Pharmacodynamics, and Safety of Metrifonate in Patients with Alzheimer's Disease by Pettigrew, L. Creed, Bieber, Florian, Lettieri, John, Wermeling, Daniel P., Schmitt, Frederick A., Tikhtman, Alex J., Ashford, J. Wesson, Smith, Charles D., Wekstein, David R., Markesbery, William R., Orazem, John, Ruzicka, Bianca B., Mas, Janice, Gulanski, Barbara

“…Metrifonate is converted nonenzymatically to 2,2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). This 21‐day,…”
Get full text

Trace elements in Alzheimer's disease pituitary glands by Cornett, C R, Ehmann, W D, Wekstein, D R, Markesbery, W R

“…Levels of mercury (Hg), selenium (Se), iron (Fe), rubidium (Rb), and zinc (Zn) were measured in the pituitary gland to assess the possibility of a potential…”
Get full text

Dental amalgam and cognitive function in older women: findings from the Nun Study by Saxe, S R, Snowdon, D A, Wekstein, M W, Henry, R G, Grant, F T, Donegan, S J, Wekstein, D R

“…The authors determined the number and surface area of occlusal dental amalgams in a group of 129 Roman Catholic sisters who were 75 to 102 years of age…”
Get more information

Critical decline in fine motor hand movements in human aging by Smith, C D, Umberger, G H, Manning, E L, Slevin, J T, Wekstein, D R, Schmitt, F A, Markesbery, W R, Zhang, Z, Gerhardt, G A, Kryscio, R J, Gash, D M

“…Slowing of motor movements in human aging is a well-known occurrence, but its biologic basis is poorly understood. Reliable quantitation may refine…”
Get full text

Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease by Smith, C D, Pettigrew, L C, Avison, M J, Kirsch, J E, Tinkhtman, A J, Schmitt, F A, Wermeling, D P, Wekstein, D R, Markesberry, W R

“…31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young…”
Get more information

Self report of sleep symptoms in older adults : correlates of daytime sleepiness and health by SCHMITT, F. A, PHILLIPS, B. A, COOK, Y. R, BERRY, D. T. R, WEKSTEIN, D. R

“…Sleep problems in the healthy elderly were studied in 628 community-dwelling older adults. Self-report of daytime sleepiness in this group was evaluated…”
Get full text

Critical decline in fine motor hand movements in human aging by SMITH, C. D, UMBERGER, G. H, GASH, D. M, MANNING, E. L, SLEVIN, J. T, WEKSTEIN, D. R, SCHMITT, F. A, MARKESBERY, W. R, ZHANG, Z, GERHARDT, G. A, KRYSCIO, R. J

Get full text

Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project by Schmitt, F A, Wetherby, M M, Wekstein, D R, Dearth, C M, Markesbery, W R

“…Medical autopsy rates have been declining for the past several decades, yet, for more than a decade, the University of Kentucky Alzheimer's Disease Research…”
Get full text

Clinical laboratory values in the aging population by Teitz, N. W., Shuey, D. F., Wekstein, D. R.

“…Abstract…”
Get full text

Linguistic Ability in Early Life and Cognitive Function and Alzheimer's Disease in Late Life: Findings From the Nun Study by Snowdon, David A, Kemper, Susan J, Mortimer, James A, Greiner, Lydia H, Wekstein, David R, Markesbery, William R

“…Objective.—To determine if linguistic ability in early life is associated with cognitive function and Alzheimer's disease in late life.Design.—Two measures of…”
Get full text

Heart rate adaptation to exercise training in cardiac-denervated dogs by Ordway, G A, Charles, J B, Randall, D C, Billman, G E, Wekstein, D R

“…To determine the effect of cardiac denervation on the development of a training-induced decrease in heart rate at rest and during submaximal exercise, six…”
Get more information

Self-perceived information needs and concerns of elderly persons by JONES, R. A, MORROW, G. D, MORRIS, R. R, RIES, J. B, WEKSTEIN, D. R

“…The research was intended to identify the dimensions underlying self-perceived information needs and concerns of an elderly population. The spontaneously…”
Get full text

N-terminal Heterogeneity of Parenchymal and Cerebrovascular Aβ Deposits by Tekirian, Tina L, Saido, Takaomi C, Markesbery, William R, Russell, Michael J, Wekstein, David R, Patel, Ela, Geddes, James W

“…The goals of this study were twofoldto determine whether species differences in Aβ N-terminal heterogeneity explain the absence of neuritic plaques in the aged…”
Get full text

The immune status of healthy centenarians by Thompson, J S, Wekstein, D R, Rhoades, J L, Kirkpatrick, C, Brown, S A, Roszman, T, Straus, R, Tietz, N

“…The immune status of 17 healthy individuals 100-103 years of age (centenarians) was investigated. Qualitative values for immunoglobulins IgG, IgM, IgA, and IgE…”
Get more information