Search Results - "Weksler, Marc E."

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease by Relkin, Norman R, Szabo, Paul, Adamiak, Basia, Burgut, Tuna, Monthe, Carmen, Lent, Richard W, Younkin, Steven, Younkin, Linda, Schiff, Richard, Weksler, Marc E

“…Abstract Intravenous immunoglobulin (IVIg) has been proposed as a potential agent for Alzheimer's disease (AD) immunotherapy because it contains antibodies…”
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Natural human antibodies to amyloid beta peptide by Szabo, Paul, Relkin, Norman, Weksler, Marc E

“…Abstract Properties of human, natural anti-Aβ antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the…”
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The effect of age on B cell development and humoral immunity by Weksler, Marc E, Goodhardt, Michele, Szabo, Paul

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Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals by Weksler, Marc E, Relkin, Norman, Turkenich, Rimma, LaRusse, Susan, Zhou, Ling, Szabo, Paul

“…Active immunization with the human amyloid peptide (Aβ42) or passive immunization with anti-Aβ42 antibodies protects mice that express a mutant human amyloid…”
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The immunotherapy of Alzheimer's disease by Weksler, Marc E

“…Only a small percentage of patients with Alzheimer's disease benefit from current drug therapy and for only a relatively short time. This is not surprising as…”
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Reduced EBF expression underlies loss of B‐cell potential of hematopoietic progenitors with age by Lescale, Chloé, Dias, Sheila, Maës, Jérôme, Cumano, Ana, Szabo, Paul, Charron, Dominique, Weksler, Marc E., Dosquet, Christine, Vieira, Paulo, Goodhardt, Michele

“…Summary Aging is accompanied by a reduction in the generation of B lymphocytes leading to impaired immune responses. In this study, we have investigated…”
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Autoantibody-catalyzed Hydrolysis of Amyloid β Peptide by Taguchi, Hiroaki, Planque, Stephanie, Nishiyama, Yasuhiro, Symersky, Jindrich, Boivin, Stephane, Szabo, Paul, Friedland, Robert P., Ramsland, Paul A., Edmundson, Allen B., Weksler, Marc E., Paul, Sudhir

“…We describe IgM class human autoantibodies that hydrolyze amyloid β peptide 1–40 (Aβ40). A monoclonal IgM from a patient with Waldenström's macroglobulinemia…”
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Measurement of anti-beta amyloid antibodies in human blood by Szabo, Paul, Mujalli, Diana M, Rotondi, Matthew L, Sharma, Rajal, Weber, Alfred, Schwarz, Hans-Peter, Weksler, Marc E, Relkin, Norman

“…Abstract The human IgG repertoire contains endogenous antibodies against beta amyloid (Aβ) that may be relevant to the pathogenesis and treatment of…”
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Changes in the B-cell repertoire with age by Weksler, Marc E

“…Changes in the B-cell repertoire during aging include a shift in antibody specificities from foreign to autologous antigens associated with a decline in the…”
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Immune therapy for age-related diseases by Weksler, Marc E, Pawelec, Graham, Franceschi, Claudio

“…Human aging is reaching epidemic proportions as life expectancy increases and birth rate decreases. These demographic trends have led to a sharp increase in…”
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Naming streets for physicians: "l'affaire Carrel" by Weksler, Marc E

“…In the 1970s, Paris and many other French cities named streets in honor of Alexis Carrel, the French physician, scientist, and Nobel laureate. Controversy…”
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The epidemic of distraction by Weksler, Marc E, Weksler, Babette B

“…Multitasking is a rapidly growing phenomenon affecting all segments of the population but is rarely as successful as its proponents believe. The use of mobile…”
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Alzheimer's disease and Down's syndrome: Treating two paths to dementia by Weksler, Marc E, Szabo, Paul, Relkin, Norman R, Reidenberg, Marcus M, Weksler, Babette B, Coppus, Antonia M.W

“…Abstract Successful therapy of dementia, like any disease, depends upon understanding its pathogenesis. This review contrasts the dominant pathways to dementia…”
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The immune system, amyloid-β peptide, and Alzheimer's disease by Weksler, Marc E., Gouras, Gunnar, Relkin, Norman R., Szabo, Paul

“…In this review, the case is made that amyloid‐β peptide in the brain of patients with Alzheimer's disease is a primary cause of the disease and that…”
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Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease by Taguchi, Hiroaki, Planque, Stephanie, Nishiyama, Yasuhiro, Szabo, Paul, Weksler, Marc E, Friedland, Robert P, Paul, Sudhir

“…Abstract Immunoglobulins (Igs) that bind amyloid β peptide (Aβ) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs…”
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Age-associated defects in B lymphocyte development by Szabo, Paul, Shen, Steven, Weksler, Marc E

“…The steady-state level of both RAG-1 and RAG-2 mRNA, the number of Pre-B cells, and the number of Pre-B cells expressing RAG-2 protein decrease in the bone…”
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Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development by LeMaoult, Joël, Szabo, Paul, Weksler, Marc E.

“…The age‐associated changes in humoral Immunity affect the quality more than the quality of the antibody response. Changes in the quality of the antibody…”
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Age matters:  Young T lymphocytes offer better protection from myeloma proliferation by Glick, Alexander F, Song, Yan S, Hwang, Brian, Lillvis, John, Zanzonico, Pat, Fuchs, Camil, Pearse, Roger N, Szabo, Paul, Weksler, Marc E

“…The incidence and growth of cancer has been reported to increase with age and/or impaired T lymphocyte function. Consistent with these observations, we found…”
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Antibodies as defensive enzymes by Paul, Sudhir, Nishiyama, Yasuhiro, Planque, Stephanie, Karle, Sangeeta, Taguchi, Hiroaki, Hanson, Carl, Weksler, Marc E

“…Antibodies (Abs) and enzymes are structural and functional relatives. Abs with promiscuous peptidase activity are ubiquitous in healthy humans, evidently…”
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Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria by Karadimitris, Anastasios, Manavalan, John S., Thaler, Howard T., Notaro, Rosario, Araten, David J., Nafa, Khedoudja, Roberts, Irene A.G., Weksler, Marc E., Luzzatto, Lucio

“…Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell (HSC). Somatic mutations in thePIG-Agene result in the…”
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