Search Results - "Weixel, Kelly M."

Phosphatidylinositol 4-Phosphate Formation at ER Exit Sites Regulates ER Export by Blumental-Perry, Anna, Haney, Charles J., Weixel, Kelly M., Watkins, Simon C., Weisz, Ora A., Aridor, Meir

“…The mechanisms that regulate endoplasmic reticulum (ER) exit-site (ERES) assembly and COPII-mediated ER export are currently unknown. We analyzed the role of…”
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Distinct Golgi Populations of Phosphatidylinositol 4-Phosphate Regulated by Phosphatidylinositol 4-Kinases by Weixel, Kelly M., Blumental-Perry, Anna, Watkins, Simon C., Aridor, Meir, Weisz, Ora A.

“…Phosphatidylinositol 4-phosphate (PI4P) regulates biosynthetic membrane traffic at multiple steps and differentially affects the surface delivery of apically…”
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Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells by Weixel, Kelly M, Marciszyn, Allison, Alzamora, Rodrigo, Li, Hui, Fischer, Oliver, Edinger, Robert S, Hallows, Kenneth R, Johnson, John P

“…Resveratrol, a naturally occurring phytoalexin, has reported cardioprotective, anti-inflammatory, chemopreventative and antidiabetic properties. Several…”
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Posttranslational Cleavage and Adaptor Protein Complex-dependent Trafficking of Mucolipin-1 by Miedel, Mark T., Weixel, Kelly M., Bruns, Jennifer R., Traub, Linton M., Weisz, Ora A.

“…Mucolipin-1 (ML1) is a member of the transient receptor potential ion channel superfamily that is thought to function in the biogenesis of lysosomes. Mutations…”
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Phosphatidylinositol 5-Kinase Stimulates Apical Biosynthetic Delivery via an Arp2/3-dependent Mechanism by Guerriero, Christopher J., Weixel, Kelly M., Bruns, Jennifer R., Weisz, Ora A.

“…The mechanisms by which polarized epithelial cells target distinct carriers enriched in newly synthesized proteins to the apical or basolateral membrane remain…”
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Phosphatidylinositol 4-Phosphate 5-Kinase Reduces Cell Surface Expression of the Epithelial Sodium Channel (ENaC) in Cultured Collecting Duct Cells by Weixel, Kelly M., Edinger, Robert S., Kester, Lauren, Guerriero, Christopher J., Wang, Huamin, Fang, Liang, Kleyman, Thomas R., Welling, Paul A., Weisz, Ora A., Johnson, John P.

“…Ubiquitination of ENaC subunits has been shown to negatively regulate the cell surface expression of ENaC channels. We have previously demonstrated that epsin…”
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Recycling of MUC1 Is Dependent on Its Palmitoylation by Kinlough, Carol L., McMahan, Rebecca J., Poland, Paul A., Bruns, James B., Harkleroad, Keri L., Stremple, Richard J., Kashlan, Ossama B., Weixel, Kelly M., Weisz, Ora A., Hughey, Rebecca P.

“…MUC1 is a mucin-like transmembrane protein expressed on the apical surface of epithelia, where it protects the cell surface. The cytoplasmic domain has…”
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N‐Glycans Mediate Apical Recycling of the Sialomucin Endolyn in Polarized MDCK Cells by Potter, Beth A., Weixel, Kelly M., Bruns, Jennifer R., Ihrke, Gudrun, Weisz, Ora A.

“…Apical and basolateral proteins are maintained within distinct membrane subdomains in polarized epithelial cells by biosynthetic and postendocytic sorting…”
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Differential Current Decay Profiles of Epithelial Sodium Channel Subunit Combinations in Polarized Renal Epithelial Cells by Mohan, Savita, Bruns, Jennifer R, Weixel, Kelly M, Edinger, Robert S, Bruns, James B, Kleyman, Thomas R, Johnson, John P, Weisz, Ora A

“…In many epithelial tissues in the body, the rate of Na + reabsorption is governed by the activity of the epithelial sodium channel (ENaC). The assembly,…”
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Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis by Miedel, Mark T, Rbaibi, Youssef, Guerriero, Christopher J, Colletti, Grace, Weixel, Kelly M, Weisz, Ora A, Kiselyov, Kirill

“…The lysosomal storage disorder mucolipidosis type IV (MLIV) is caused by mutations in the transient receptor potential-mucolipin-1 (TRP-ML1) ion channel. The…”
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Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin by Wang, Huamin, Traub, Linton M, Weixel, Kelly M, Hawryluk, Mathew J, Shah, Nirav, Edinger, Robert S, Perry, Clint J, Kester, Lauren, Butterworth, Michael B, Peters, Kathryn W, Kleyman, Thomas R, Frizzell, Raymond A, Johnson, John P

“…Here we present evidence that the epithelial sodium channel (ENaC), a heteromeric membrane protein whose surface expression is regulated by ubiquitination, is…”
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Specific N-glycans direct apical delivery of transmembrane, but not soluble or glycosylphosphatidylinositol-anchored forms of endolyn in Madin-Darby canine kidney cells by Potter, Beth A, Ihrke, Gudrun, Bruns, Jennifer R, Weixel, Kelly M, Weisz, Ora A

“…The sialomucin endolyn is a transmembrane protein with a unique trafficking pattern in polarized Madin-Darby canine kidney cells. Despite the presence of a…”
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The Carboxyl Terminus of the Cystic Fibrosis Transmembrane Conductance Regulator Binds to AP-2 Clathrin Adaptors by Weixel, Kelly M., Bradbury, Neil A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) undergoes rapid and efficient endocytosis. Since functionally active CFTR is found in purified…”
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Association of gag multimers with filamentous actin during equine infectious anemia virus assembly by Chen, Chaoping, Jin, Jing, Rubin, Marc, Huang, Liangqun, Sturgeon, Timothy, Weixel, Kelly M, Stolz, Donna B, Watkins, Simon C, Bamburg, James R, Weisz, Ora A, Montelaro, Ronald C

“…A role for the actin cytoskeleton in retrovirus assembly has long been speculated. However, specific mechanisms by which actin facilitates the assembly process…”
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Clathrin-mediated Endocytosis of the Epithelial Sodium Channel by Wang, Huamin, Traub, Linton M., Weixel, Kelly M., Hawryluk, Mathew J., Shah, Nirav, Edinger, Robert S., Perry, Clint J., Kester, Lauren, Butterworth, Michael B., Peters, Kathryn W., Kleyman, Thomas R., Frizzell, Raymond A., Johnson, John P.

“…Here we present evidence that the epithelial sodium channel (ENaC), a heteromeric membrane protein whose surface expression is regulated by ubiquitination, is…”
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μ2 Binding Directs the Cystic Fibrosis Transmembrane Conductance Regulator to the Clathrin-mediated Endocytic Pathway by Weixel, Kelly M., Bradbury, Neil A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) contains a conserved tyrosine-based internalization motif, 1424YDSI, which interacts with the…”
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Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis by Miedel, Mark T., Rbaibi, Youssef, Guerriero, Christopher J., Colletti, Grace, Weixel, Kelly M., Weisz, Ora A., Kiselyov, Kirill

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Complex regulation of the epithelial Na+ channel (ENaC) by phosphatidylinsoitol bisphosphate (PIP2) by Edinger, Robert S, Kester, Lauren, Weixel, Kelly M, Johnson, John P

“…Phosphatidylinositol‐5 kinase α (PIP5Kα) has been shown to stimulate PIP2 production and induce exocytosis of ENaC, increasing surface expression. PIP2 has…”
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μ2 Binding Directs the Cystic Fibrosis Transmembrane Conductance Regulator to the Clathrin-mediated Endocytic Pathway by Kelly M. Weixel, Neil A. Bradbury

“…The cystic fibrosis transmembrane conductance regulator (CFTR) contains a conserved tyrosine-based internalization motif, 1424 YDSI, which interacts with the…”
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Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells by Basu, A, Weixel, K M

“…Cellular sensitivity to cis-diamminedichloroplatinum(II) (cDDP) can be regulated by protein kinase C (PKC) signal transduction pathway. Activators of PKC were…”
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