Short-Term Daily Intake of Polydextrose Fiber Does Not Shorten Intestinal Transit Time in Constipated Adults: A Randomized Controlled Trial

Short-Term Daily Intake of Polydextrose Fiber Does Not Shorten Intestinal Transit Time in Constipated Adults: A Randomized Controlled Trial

Chronic constipation (CC) remains a common gastrointestinal (GI) disorder that conveys a substantial healthcare burden. Expert guidelines recommend increasing fiber intake, yet the clinical evidence to support this needs strengthening for specific fibers. The aim was to evaluate changes in intestina...

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Bibliographic Details
Published in:Nutrients Vol. 10; no. 7; p. 920
Main Authors: Duncan, Peter I, Enters-Weijnen, Catherine F, Emami, Nashmil, McLean, Peter, Nunes, Tiago, Beaumont, Maurice, Crabbe, Rafael, Whelan, Kevin, Scott, S Mark, deWit, Niek J, Weits, Teunis, Bergonzelli, Gabriela, Grobbee, Diederick E
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 19-07-2018
MDPI
Subjects:
adult
Adults
Clinical trials
Constipation
fiber
Fibers
Health care
Intervention
intestinal function
intestinal transit
Intestinal transit time
Intestine
patient-reported outcome
Polydextrose
Quality of life
Randomization
randomized controlled trial
Rectum
constipation
fiber
polydextrose
intestinal transit
intestinal function
patient-reported outcome
adult
randomized controlled trial
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Summary:Chronic constipation (CC) remains a common gastrointestinal (GI) disorder that conveys a substantial healthcare burden. Expert guidelines recommend increasing fiber intake, yet the clinical evidence to support this needs strengthening for specific fibers. The aim was to evaluate changes in intestinal transit time and GI symptoms in CC patients who consumed polydextrose. In a randomized, double-blind, placebo-controlled trial, 128 adults with CC received 8 g or 12 g polydextrose, or placebo, daily for 4 weeks. Transit time, as primary outcome, was assessed by radiopaque marker distribution after 2-weeks intervention. Bowel habits, GI symptoms and quality of life (QOL) were assessed by questionnaire, including the Patient-Assessment of Constipation (PAC) Symptoms (SYM), and PAC-QOL. Following 2-weeks intervention, no reduction was seen in transit time in any group and following 2- or 4-weeks intervention, no improvements were seen in stool frequency or consistency in any group. After 2-weeks intervention with 8 g/day polydextrose an improvement was seen in the PAC-SYM rectal score ( = 0.041). After 4-weeks intervention both rectal ( = 0.049) and stool ( = 0.029) scores improved while improvement in the QOL satisfaction score did not reach significance ( = 0.071). Overall, the results suggest that 2-weeks consumption of 8 or 12 g/day polydextrose does not significantly improve physiological measures of gut function in CC adults. Longer term consumption may improve clinical measures, but further studies will be required to substantiate this.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu10070920