Search Results - "Weithauser, Alice"

PAR-1 contributes to the innate immune response during viral infection by Antoniak, Silvio, Owens, 3rd, A Phillip, Baunacke, Martin, Williams, Julie C, Lee, Rebecca D, Weithäuser, Alice, Sheridan, Patricia A, Malz, Ronny, Luyendyk, James P, Esserman, Denise A, Trejo, JoAnn, Kirchhofer, Daniel, Blaxall, Burns C, Pawlinski, Rafal, Beck, Melinda A, Rauch, Ursula, Mackman, Nigel

“…Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In…”
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Micro–RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue Factor by Witkowski, Marco, Weithauser, Alice, Tabaraie, Termeh, Steffens, Daniel, Kränkel, Nicolle, Witkowski, Mario, Stratmann, Bernd, Tschoepe, Diethelm, Landmesser, Ulf, Rauch-Kroehnert, Ursula

“…OBJECTIVE—Diabetes mellitus involves vascular inflammatory processes and is a main contributor to cardiovascular mortality. Notably, heightened levels of…”
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Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction by Friebel, Julian, Weithauser, Alice, Witkowski, Marco, Rauch, Bernhard H, Savvatis, Konstantinos, Dörner, Andrea, Tabaraie, Termeh, Kasner, Mario, Moos, Verena, Bösel, Diana, Gotthardt, Michael, Radke, Michael H, Wegner, Max, Bobbert, Peter, Lassner, Dirk, Tschöpe, Carsten, Schutheiss, Heinz-Peter, Felix, Stephan B, Landmesser, Ulf, Rauch, Ursula

“…Abstract Aims Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular…”
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Role of protease-activated receptors for the innate immune response of the heart by Weithauser, Alice, PhD, Rauch, Ursula, MD

“…Abstract Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a unique activation mechanism via cleavage by the serine…”
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Cell type-specific roles of PAR1 in Coxsackievirus B3 infection by Bode, Michael F., Schmedes, Clare M., Egnatz, Grant J., Bharathi, Vanthana, Hisada, Yohei M., Martinez, David, Kawano, Tomohiro, Weithauser, Alice, Rosenfeldt, Leah, Rauch, Ursula, Palumbo, Joseph S., Antoniak, Silvio, Mackman, Nigel

“…Protease-activated receptor 1 (PAR1) is widely expressed in humans and mice, and is activated by a variety of proteases, including thrombin. Recently, we…”
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Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3–Induced Myocarditis by Weithauser, Alice, PhD, Bobbert, Peter, MD, Antoniak, Silvio, PhD, Böhm, Andreas, MSc, Rauch, Bernhard H., MD, Klingel, Karin, MD, Savvatis, Konstantinos, MD, Kroemer, Heyo K., PhD, Tschope, Carsten, MD, Stroux, Andrea, MSc, Zeichhardt, Heinz, PhD, Poller, Wolfgang, MD, Mackman, Nigel, PhD, Schultheiss, Heinz-Peter, MD, Rauch, Ursula, MD

“…Objectives This study sought to evaluate the role of protease-activated receptor-2 (PAR2) in coxsackievirus B3 (CVB3)–induced myocarditis. Background An…”
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The Role of Protease-Activated Receptors for the Development of Myocarditis: Possible Therapeutic Implications by Weithauser, Alice, Witkowski, Marco, Rauch, Ursula

“…Protease-activated receptors (PARs) are a unique group of four G-protein coupled receptors. They are widely expressed within the cardiovascular system and the…”
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Inhibition of coagulation factor Xa improves myocardial function during CVB3-induced myocarditis by Malz, Ronny, Weithauser, Alice, Tschöpe, Carsten, Schultheiss, Heinz-Peter, Rauch, Ursula

“…Myocarditis is induced by coxsackievirus B3 (CVB3). Myocardial inflammation is tied to the activation of coagulation. Coagulation factor (F) Xa, a central…”
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Mesenchymal stromal cells but not cardiac fibroblasts exert beneficial systemic immunomodulatory effects in experimental myocarditis by Savvatis, Konstantinos, van Linthout, Sophie, Miteva, Kapka, Pappritz, Kathleen, Westermann, Dirk, Schefold, Joerg C, Fusch, Gerhard, Weithäuser, Alice, Rauch, Ursula, Becher, Peter-Moritz, Klingel, Karin, Ringe, Jochen, Kurtz, Andreas, Schultheiss, Heinz-Peter, Tschöpe, Carsten

“…Systemic application of mesenchymal stromal cells (MSCs) in inflammatory cardiomyopathy exerts cardiobeneficial effects. The mode of action is unclear since a…”
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Leptin and resistin induce increased procoagulability in diabetes mellitus by Bobbert, Peter, Eisenreich, Andreas, Weithäuser, Alice, Schultheiss, Heinz Peter, Rauch, Ursula

“…► Our study elucidated the role of leptin/resistin in hypercoagulability in patients with diabetes. ► Patients with diabetes showed increased plasma levels of…”
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THE DEFICIENCY OF PROTEASE-ACTIVATED RECEPTOR 2 LEADS TO AN AGE DEPENDENT CARDIAC FIBROSIS AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION by Rauch-Kröhnert, Ursula, Weithauser, Alice, Savvatis, Konstantinos, Schultheiss, Heinz-Peter

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Endothelial micrornas epigenetically control vascular inflammation and thrombogenicity in diabetes by Witkowski, Marco, Weithauser, Alice, Tabaraie, Termeh, Steffens, Daniel, Friebel, Julian, Stratmann, Bernd, Tschoepe, Diethelm, Landmesser, Ulf, Rauch, Ursula

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ADIPONECTIN PROMOTES COXSACKIEVIRUS B3 MYOCARDITIS BY SUPPRESSING THE ACUTE ANTIVIRAL IMMUNE RESPONSE by Skurk, Carsten, Jenke, Alexander, Becher, Moritz, Weithäuser, Alice, Klingel, Karin, Schultheiss, Heinz-Peter, Scheibenbogen, Carmen

“…Conclusion Our observations indicate that APN promotes development of CVB3 myocarditis by modulating polarization of activated macrophages towards an…”
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Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy by Bobbert, Peter, Weithäuser, Alice, Andres, Janin, Bobbert, Thomas, Kühl, Uwe, Schultheiss, Heinz Peter, Rauch, Ursula, Skurk, Carsten

“…Aims Chronic heart failure (CHF) is associated with a higher risk for diabetes mellitus. Retinol binding protein 4 (RBP 4) is an adipose tissue-derived protein…”
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Abstract 18765: PAR-1 Contributes to the Innate Immune Response to Viral Infection by Antoniak, Silvio, Owens, Albert P, Williams, Julie C, Lee, Rebecca D, Weithäuser, Alice, Baunacke, Martin, Sheridan, Patricia A, Malz, Ronny, Pawlinski, Rafal, Blaxall, Burns, Beck, Melinda A, Rauch, Ursula, Mackman, Nigel

“…Abstract only Objective: Viral infections activate the blood coagulation cascade as part of the host defense response. Coagulation proteases, such as thrombin,…”
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Abstract 18765: PAR-1 Contributes to the Innate Immune Response to Viral Infection by Antoniak, Silvio, Owens, Albert P, Williams, Julie C, Lee, Rebecca D, Weithäuser, Alice, Baunacke, Martin, Sheridan, Patricia A, Malz, Ronny, Pawlinski, Rafal, Blaxall, Burns, Beck, Melinda A., Rauch, Ursula, Mackman, Nigel

“…Abstract only Silvio Antoniak, 2012 Finalist and Presenting Author…”
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