Search Results - "Weisz, A"

Receptor-Mediated Endocytosis in the Proximal Tubule by Eshbach, Megan L, Weisz, Ora A

“…Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the…”
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Apical trafficking in epithelial cells: signals, clusters and motors by Weisz, Ora A, Rodriguez-Boulan, Enrique

“…In the early days of epithelial cell biology, researchers working with kidney and/or intestinal epithelial cell lines and with hepatocytes described the…”
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Discerning the role of mechanosensors in regulating proximal tubule function by Raghavan, Venkatesan, Weisz, Ora A

“…All cells in the body experience external mechanical forces such as shear stress and stretch. These forces are sensed by specialized structures in the cell…”
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Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia by Raghavan, Venkatesan, Rbaibi, Youssef, Pastor-Soler, Núria M., Carattino, Marcelo D., Weisz, Ora A.

“…The kidney has an extraordinary ability to maintain stable fractional solute and fluid reabsorption over a wide range of glomerular filtration rates (GFRs)…”
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Traumatic brain injury induces long-lasting changes in immune and regenerative signaling by Boone, Deborah R, Weisz, Harris A, Willey, Hannah E, Torres, Karen E O, Falduto, Michael T, Sinha, Mala, Spratt, Heidi, Bolding, Ian J, Johnson, Kathea M, Parsley, Margaret A, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…There are no existing treatments for the long-term degenerative effects of traumatic brain injury (TBI). This is due, in part, to our limited understanding of…”
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Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin by Ren, Qidong, Weyer, Kathrin, Rbaibi, Youssef, Long, Kimberly R, Tan, Roderick J, Nielsen, Rikke, Christensen, Erik I, Baty, Catherine J, Kashlan, Ossama B, Weisz, Ora A

“…Proximal tubule (PT) cells express a single saturable albumin-binding site whose affinity matches the estimated tubular concentration of albumin; however,…”
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Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension by Rinschen, Markus M., Palygin, Oleg, El-Meanawy, Ashraf, Domingo-Almenara, Xavier, Palermo, Amelia, Dissanayake, Lashodya V., Golosova, Daria, Schafroth, Michael A., Guijas, Carlos, Demir, Fatih, Jaegers, Johannes, Gliozzi, Megan L., Xue, Jingchuan, Hoehne, Martin, Benzing, Thomas, Kok, Bernard P., Saez, Enrique, Bleich, Markus, Himmerkus, Nina, Weisz, Ora A., Cravatt, Benjamin F., Krüger, Marcus, Benton, H. Paul, Siuzdak, Gary, Staruschenko, Alexander

“…Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope…”
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DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells by Pistore, C, Giannoni, E, Colangelo, T, Rizzo, F, Magnani, E, Muccillo, L, Giurato, G, Mancini, M, Rizzo, S, Riccardi, M, Sahnane, N, Del Vescovo, V, Kishore, K, Mandruzzato, M, Macchi, F, Pelizzola, M, Denti, M A, Furlan, D, Weisz, A, Colantuoni, V, Chiarugi, P, Bonapace, I M

“…Widespread genome hypo-methylation and promoter hyper-methylation of epithelium-specific genes are hallmarks of stable epithelial-to-mesenchymal transition…”
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Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway by Long, Kimberly R, Shipman, Katherine E, Rbaibi, Youssef, Menshikova, Elizabeth V, Ritov, Vladimir B, Eshbach, Megan L, Jiang, Yu, Jackson, Edwin K, Baty, Catherine J, Weisz, Ora A

“…Cells lining the proximal tubule (PT) have unique membrane specializations that are required to maintain the high-capacity ion transport and endocytic…”
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A novel chlorophyll protein complex in the repair cycle of photosystem II by Weisz, Daniel A., Johnson, Virginia M., Niedzwiedzki, Dariusz M., Shinn, Min Kyung, Liu, Haijun, Klitzke, Clécio F., Gross, Michael L., Blankenship, Robert E., Lohman, Timothy M., Pakrasi, Himadri B.

“…In oxygenic photosynthetic organisms, photosystem II (PSII) is a unique membrane protein complex that catalyzes light-driven oxidation of water. PSII undergoes…”
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Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19 by Sell, Stacy L, Prough, Donald S, Weisz, Harris A, Widen, Steve G, Hellmich, Helen L

“…Many important questions remain regarding severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These…”
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Impaired Endosome Maturation Mediates Tubular Proteinuria in Dent Disease Cell Culture and Mouse Models by Shipman, Katherine E, Baty, Catherine J, Long, Kimberly R, Rbaibi, Youssef, Cowan, Isabella A, Gerges, Mona, Marciszyn, Allison L, Kashlan, Ossama B, Tan, Roderick J, Edwards, Aurélie, Weisz, Ora A

“…Loss of function of the 2Cl - /H + antiporter ClC-5 in Dent disease causes an unknown impairment in endocytic traffic, leading to tubular proteinuria. The…”
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MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries by Weisz, Harris A., Kennedy, Deborah, Widen, Steven, Spratt, Heidi, Sell, Stacy L., Bailey, Christine, Sheffield-Moore, Melinda, DeWitt, Douglas S., Prough, Donald S., Levin, Harvey, Robertson, Claudia, Hellmich, Helen L.

“…High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs…”
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MS-based cross-linking analysis reveals the location of the PsbQ protein in cyanobacterial photosystem II by Liu, Haijun, Zhang, Hao, Weisz, Daniel A., Vidavsky, Ilan, Gross, Michael L., Pakrasi, Himadri B.

“…PsbQ is a luminal extrinsic protein component that regulates the water splitting activity of photosystem II (PSII) in plants, algae, and cyanobacteria…”
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Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line by Weisz, Harris A, Boone, Deborah R, Coggins, William S, Edwards, Gabrielle A, Willey, Hannah E, Widen, Steven G, Siegel, Dionicio, Nelson, Andrew T, Prough, Donald S, Hellmich, Helen L

“…Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort…”
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Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport by Sneddon, W. Bruce, Ruiz, Giovanni W., Gallo, Luciana I., Xiao, Kunhong, Zhang, Qiangmin, Rbaibi, Youssef, Weisz, Ora A., Apodaca, Gerard L., Friedman, Peter A.

“…Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to…”
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Fluid shear stress-induced changes in megalin trafficking enhance endocytic capacity in proximal tubule cells by Lackner, Emily M, Cowan, Isabella A, Long, Kimberly R, Weisz, Ora A, Shipman, Katherine E

“…Proximal tubule (PT) cells maintain a high-capacity apical endocytic pathway to recover essentially all proteins that escape the glomerular filtration barrier…”
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Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy by Montico, B., Lapenta, C., Ravo, M., Martorelli, D., Muraro, E., Zeng, B., Comaro, E., Spada, M., Donati, S., Santini, S. M., Tarallo, R., Giurato, G., Rizzo, F., Weisz, A., Belardelli, F., Dolcetti, R., Dal Col, J.

“…Although promising, the clinical benefit provided by dendritic cell (DC)-based vaccines is still limited and the choice of the optimal antigen formulation is…”
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Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture by Park, Hyun Jung, Fan, Zhenjiang, Bai, Yulong, Ren, Qidong, Rbaibi, Youssef, Long, Kimberly R, Gliozzi, Megan L, Rittenhouse, Natalie, Locker, Joseph D, Poholek, Amanda C, Weisz, Ora A

“…Cultured cell models are an essential complement to dissecting kidney proximal tubule (PT) function in health and disease but do not fully recapitulate key…”
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Taking the Scenic Route: Biosynthetic Traffic to the Plasma Membrane in Polarized Epithelial Cells by Fölsch, Heike, Mattila, Polly E, Weisz, Ora A

“…The maintenance of epithelial cell function requires the establishment and continuous renewal of differentiated apical and basolateral plasma membrane domains…”
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