Search Results - "Weissman, Irving L"

The Role of Efferocytosis in Atherosclerosis by Kojima, Yoko, Weissman, Irving L, Leeper, Nicholas J

“…The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue…”
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Phagocytosis checkpoints as new targets for cancer immunotherapy by Feng, Mingye, Jiang, Wen, Kim, Betty Y. S., Zhang, Cheng Cheng, Fu, Yang-Xin, Weissman, Irving L.

“…Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory…”
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Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development by Weissman, Irving L

“…It is obvious that natural selection operates at the level of individuals and collections of individuals. Nearly two decades ago we showed that in…”
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Hematopoietic stem cell: self-renewal versus differentiation by Seita, Jun, Weissman, Irving L.

“…The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the…”
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Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies by Lee, Andrew S, Tang, Chad, Rao, Mahendra S, Weissman, Irving L, Wu, Joseph C

“…There is much interest in the applications of pluripotent stem cells for regenerative medicine. In this Perspective, the authors discuss the factors that might…”
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A molecular cell atlas of the human lung from single-cell RNA sequencing by Travaglini, Kyle J., Nabhan, Ahmad N., Penland, Lolita, Sinha, Rahul, Gillich, Astrid, Sit, Rene V., Chang, Stephen, Conley, Stephanie D., Mori, Yasuo, Seita, Jun, Berry, Gerald J., Shrager, Joseph B., Metzger, Ross J., Kuo, Christin S., Neff, Norma, Weissman, Irving L., Quake, Stephen R., Krasnow, Mark A.

“…Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles 1 – 9 , it has been difficult to systematically…”
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Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle by Beerman, Isabel, Seita, Jun, Inlay, Matthew A., Weissman, Irving L., Rossi, Derrick J.

“…Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system throughout life. It has been postulated that HSCs may be uniquely capable…”
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Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo by Lu, Rong, Czechowicz, Agnieszka, Seita, Jun, Jiang, Du, Weissman, Irving L.

“…While the aggregate differentiation of the hematopoietic stem cell (HSC) population has been extensively studied, little is known about the lineage commitment…”
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Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential by Liu, Jie, Wang, Lijuan, Zhao, Feifei, Tseng, Serena, Narayanan, Cyndhavi, Shura, Lei, Willingham, Stephen, Howard, Maureen, Prohaska, Susan, Volkmer, Jens, Chao, Mark, Weissman, Irving L, Majeti, Ravindra

“…CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis mediated by cells of the innate immune system, such as…”
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CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma by Advani, Ranjana, Flinn, Ian, Popplewell, Leslie, Forero, Andres, Bartlett, Nancy L, Ghosh, Nilanjan, Kline, Justin, Roschewski, Mark, LaCasce, Ann, Collins, Graham P, Tran, Thu, Lynn, Judith, Chen, James Y, Volkmer, Jens-Peter, Agoram, Balaji, Huang, Jie, Majeti, Ravindra, Weissman, Irving L, Takimoto, Chris H, Chao, Mark P, Smith, Sonali M

“…An antibody to CD47 used in combination with rituximab induced responses in half of a small group of patients with refractory B-cell lymphoma. Inhibiting the…”
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Breaking Down the Barriers to Precision Cancer Nanomedicine by von Roemeling, Christina, Jiang, Wen, Chan, Charles K, Weissman, Irving L, Kim, Betty Y.S

“…Nanomedicine offers unique advantages in treating human cancers. However, physiological and pathological barriers within normal and disease tissues, which are…”
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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission by Corces-Zimmerman, M. Ryan, Hong, Wan-Jen, Weissman, Irving L., Medeiros, Bruno C., Majeti, Ravindra

“…Cancer is widely characterized by the sequential acquisition of genetic lesions in a single lineage of cells. Our previous studies have shown that, in acute…”
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types by Loh, Kyle M., Chen, Angela, Koh, Pang Wei, Deng, Tianda Z., Sinha, Rahul, Tsai, Jonathan M., Barkal, Amira A., Shen, Kimberle Y., Jain, Rajan, Morganti, Rachel M., Shyh-Chang, Ng, Fernhoff, Nathaniel B., George, Benson M., Wernig, Gerlinde, Salomon, Rachel E.A., Chen, Zhenghao, Vogel, Hannes, Epstein, Jonathan A., Kundaje, Anshul, Talbot, William S., Beachy, Philip A., Ang, Lay Teng, Weissman, Irving L.

“…Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive…”
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Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche by Chen, James Y., Miyanishi, Masanori, Wang, Sean K., Yamazaki, Satoshi, Sinha, Rahul, Kao, Kevin S., Seita, Jun, Sahoo, Debashis, Nakauchi, Hiromitsu, Weissman, Irving L.

“…Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology…”
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Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice by Ali, Shah R., Hippenmeyer, Simon, Saadat, Lily V., Luo, Liqun, Weissman, Irving L., Ardehali, Reza

“…The mammalian heart has long been considered a postmitotic organ, implying that the total number of cardiomyocytes is set at birth. Analysis of cell division…”
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Identification of the Human Skeletal Stem Cell by Chan, Charles K.F., Gulati, Gunsagar S., Sinha, Rahul, Tompkins, Justin Vincent, Lopez, Michael, Carter, Ava C., Ransom, Ryan C., Reinisch, Andreas, Wearda, Taylor, Murphy, Matthew, Brewer, Rachel E., Koepke, Lauren S., Marecic, Owen, Manjunath, Anoop, Seo, Eun Young, Leavitt, Tripp, Lu, Wan-Jin, Nguyen, Allison, Conley, Stephanie D., Salhotra, Ankit, Ambrosi, Thomas H., Borrelli, Mimi R., Siebel, Taylor, Chan, Karen, Schallmoser, Katharina, Seita, Jun, Sahoo, Debashis, Goodnough, Henry, Bishop, Julius, Gardner, Michael, Majeti, Ravindra, Wan, Derrick C., Goodman, Stuart, Weissman, Irving L., Chang, Howard Y., Longaker, Michael T.

“…Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing…”
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Reactivation of the pluripotency program precedes formation of the cranial neural crest by Zalc, Antoine, Sinha, Rahul, Gulati, Gunsagar S, Wesche, Daniel J, Daszczuk, Patrycja, Swigut, Tomek, Weissman, Irving L, Wysocka, Joanna

“…During development, cells progress from a pluripotent state to a more restricted fate within a particular germ layer. However, cranial neural crest cells…”
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New tools for studying microglia in the mouse and human CNS by Bennett, Mariko L., Bennett, F. Chris, Liddelow, Shane A., Ajami, Bahareh, Zamanian, Jennifer L., Fernhoff, Nathaniel B., Mulinyawe, Sara B., Bohlen, Christopher J., Adil, Aykezar, Tucker, Andrew, Weissman, Irving L., Chang, Edward F., Li, Gordon, Grant, Gerald A., Gephart, Melanie G. Hayden, Barres, Ben A.

“…The specific function of microglia, the tissue resident macrophages of the brain and spinal cord, has been difficult to ascertain because of a lack of tools to…”
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Unifying mechanism for different fibrotic diseases by Wernig, Gerlinde, Chen, Shih-Yu, Cui, Lu, Van Neste, Camille, Tsai, Jonathan M., Kambham, Neeraja, Vogel, Hannes, Natkunam, Yaso, Gilliland, D. Gary, Nolan, Garry, Weissman, Irving L.

“…Fibrotic diseases are not well-understood. They represent a number of different diseases that are characterized by the development of severe organ fibrosis…”
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Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies by Chao, Mark P, Takimoto, Chris H, Feng, Dong Dong, McKenna, Kelly, Gip, Phung, Liu, Jie, Volkmer, Jens-Peter, Weissman, Irving L, Majeti, Ravindra

“…In recent years, immunotherapies have been clinically investigated in AML and other myeloid malignancies. While most of these are focused on stimulating the…”
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