Search Results - "Weissbrich, Bianca"

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection by Schober, Kilian, Voit, Florian, Grassmann, Simon, Müller, Thomas R., Eggert, Joel, Jarosch, Sebastian, Weißbrich, Bianca, Hoffmann, Patrick, Borkner, Lisa, Nio, Enzo, Fanchi, Lorenzo, Clouser, Christopher R., Radhakrishnan, Aditya, Mihatsch, Lorenz, Lückemeier, Philipp, Leube, Justin, Dössinger, Georg, Klein, Ludger, Neuenhahn, Michael, Oduro, Jennifer D., Cicin-Sain, Luka, Buchholz, Veit R., Busch, Dirk H.

“…Adaptive evolution is a key feature of T cell immunity. During acute immune responses, T cells harboring high-affinity T cell antigen receptors (TCRs) are…”
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Preventing tumor escape by targeting a post-proteasomal trimming independent epitope by Textor, Ana, Schmidt, Karin, Kloetzel, Peter-M, Weißbrich, Bianca, Perez, Cynthia, Charo, Jehad, Anders, Kathleen, Sidney, John, Sette, Alessandro, Schumacher, Ton N M, Keller, Christin, Busch, Dirk H, Seifert, Ulrike, Blankenstein, Thomas

“…Adoptive T cell therapy (ATT) can achieve regression of large tumors in mice and humans; however, tumors frequently recur. High target peptide-major…”
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Flow cytometry‐based TCR‐ligand K off ‐rate assay for fast avidity screening of even very small antigen‐specific T cell populations ex vivo by Nauerth, Magdalena, Stemberger, Christian, Mohr, Fabian, Weißbrich, Bianca, Schiemann, Matthias, Germeroth, Lothar, Busch, Dirk H.

“…Abstract High epitope‐specific sensitivity of CD8 + T cells is required for optimal immune protection against intracellular pathogens as well as certain…”
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MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy by Dössinger, Georg, Bunse, Mario, Bet, Jeannette, Albrecht, Julia, Paszkiewicz, Paulina J, Weißbrich, Bianca, Schiedewitz, Isabell, Henkel, Lynette, Schiemann, Matthias, Neuenhahn, Michael, Uckert, Wolfgang, Busch, Dirk H

“…Adoptive therapy using T cells redirected to target tumor- or infection-associated antigens is a promising strategy that has curative potential and broad…”
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Mixed functional characteristics correlating with TCR‐ligand koff‐rate of MHC‐tetramer reactive T cells within the naive T‐cell repertoire by Hombrink, Pleun, Raz, Yotam, Kester, Michel G. D., Boer, Renate, Weißbrich, Bianca, dem Borne, Peter A., Busch, Dirk H., Schumacher, Ton N. M., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…The low frequency of antigen‐specific naïve T cells has challenged numerous laboratories to develop various techniques to study the naïve T‐cell repertoire…”
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Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope by Textor, Ana, Schmidt, Karin, Kloetzel, Peter-M, Weißbrich, Bianca, Perez, Cynthia, Charo, Jehad, Anders, Kathleen, Sidney, John, Sette, Alessandro, Schumacher, Ton N M, Keller, Christin, Busch, Dirk H, Seifert, Ulrike, Blankenstein, Thomas

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Disparate Individual Fates Compose Robust CD8⁺ T Cell Immunity by Buchholz, Veit R., Flossdorf, Michael, Hensel, Inge, Kretschmer, Lorenz, Weissbrich, Bianca, Gräf, Patricia, Verschoor, Admar, Schiemann, Matthias, Höfer, Thomas, Busch, Dirk H.

“…A core feature of protective T cell responses to infection is the robust expansion and diversification of naïve antigen-specific T cell populations into…”
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Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model by Jin, Benjamin Y, Campbell, Tracy E, Draper, Lindsey M, Stevanović, Sanja, Weissbrich, Bianca, Yu, Zhiya, Restifo, Nicholas P, Rosenberg, Steven A, Trimble, Cornelia L, Hinrichs, Christian S

“…T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the…”
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Flow cytometry‐based TCR‐ligand Koff‐rate assay for fast avidity screening of even very small antigen‐specific T cell populations ex vivo by Nauerth, Magdalena, Stemberger, Christian, Mohr, Fabian, Weißbrich, Bianca, Schiemann, Matthias, Germeroth, Lothar, Busch, Dirk H.

“…High epitope‐specific sensitivity of CD8+ T cells is required for optimal immune protection against intracellular pathogens as well as certain malignancies…”
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The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer by Santegoets, Saskia J., Welters, Marij J. P., Schrikkema, Deborah S., Freriks, Manon R., Kok, Hanna, Weissbrich, Bianca, van den Branden, Anouk, Linnemann, Carsten, Schumacher, Ton N., Adhikary, Sabina, Bendle, Gavin, van der Burg, Sjoerd H.

“…Immunotherapies targeting truly tumor-specific targets focus on the expansion and activation of T cells against neoantigens or oncogenic viruses. One target is…”
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TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer by Nauerth, Magdalena, Weißbrich, Bianca, Knall, Robert, Franz, Tobias, Dössinger, Georg, Bet, Jeannette, Paszkiewicz, Paulina J, Pfeifer, Lukas, Bunse, Mario, Uckert, Wolfgang, Holtappels, Rafaela, Gillert-Marien, Dorothea, Neuenhahn, Michael, Krackhardt, Angela, Reddehase, Matthias J, Riddell, Stanley R, Busch, Dirk H

“…Adoptive immunotherapy is a promising therapeutic approach for the treatment of chronic infections and cancer. T cells within a certain range of high avidity…”
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Engineered t cells targeting E7 mediate regression of human papillomavirus cancers in a murine model by Jin, Benjamin Y, Campbell, Tracy E, Draper, Lindsey, Stevanovic, Sanja, Weissbrich, Bianca, Yu, Zhiya, Restifo, Nicholas P., Rosenberg, Steven A., Trimble, Cornelia, Hinrichs, Christian S.

“…Abstract only…”
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Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity by Weissbrich, Bianca, Nauerth, Magdalena, Busch, Dirk H

“…T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel k off -rate assay allows for the…”
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Mixed functional characteristics correlating with TCR ‐ligand k off ‐rate of MHC ‐tetramer reactive T cells within the naive T ‐cell repertoire by Hombrink, Pleun, Raz, Yotam, Kester, Michel G. D., de Boer, Renate, Weißbrich, Bianca, von dem Borne, Peter A., Busch, Dirk H., Schumacher, Ton N. M., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…The low frequency of antigen‐specific naïve T cells has challenged numerous laboratories to develop various techniques to study the naïve T ‐cell repertoire…”
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The clinical potential for koff-rate measurement in adoptive immunotherapy by Nauerth, Magdalena, Weissbrich, Bianca, Busch, Dirk H

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