Anti-idiotype stimulation of antigen-specific antigen-independent antibody responses in vitro. II. Triggering of B lymphocytes by idiotype plus anti-idiotype in the absence of T lymphocytes

Antibodies specific for the idiotypes of B10 anti-(T,G)-A--L antibodies (anti-id) induced B lymphocytes to secrete anti-(T,G)-A--L antibodies in vitro in the absence of both antigen and T lymphocytes, provided either that the B lymphocytes were previously primed in vivo with (T,G)-A--L or that id sp...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 132; no. 6; pp. 2709 - 2714
Main Authors:	Shenk, RR, Weissberger, HZ, Dickler, HB
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Am Assoc Immnol 01-06-1984 American Association of Immunologists
Subjects:	Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Anti-Idiotypic - physiology Antibody-Producing Cells - immunology Antibody-Producing Cells - metabolism Antigens, T-Independent - immunology B-Lymphocytes - immunology Biological and medical sciences Cell Adhesion Cell interactions Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoglobulin Idiotypes - immunology Immunoglobulin Idiotypes - physiology Immunoglobulin M - biosynthesis Lymphocyte Activation Lymphocyte Cooperation Lymphocyte Depletion Mice Mice, Inbred C57BL Peptides - administration & dosage Peptides - immunology Rats T-Lymphocytes - immunology Antibody Rodentia B-Lymphocyte In vitro Immunological method Antigen Vertebrata Specificity Mammalia Mouse Immune stimulation Animal T-Lymphocyte Idiotype
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Summary:	Antibodies specific for the idiotypes of B10 anti-(T,G)-A--L antibodies (anti-id) induced B lymphocytes to secrete anti-(T,G)-A--L antibodies in vitro in the absence of both antigen and T lymphocytes, provided either that the B lymphocytes were previously primed in vivo with (T,G)-A--L or that id specific for (T,G)-A--L was added to the cultures. These antigen- and T lymphocyte-independent responses were antigen specific and appeared not to require accessory cells. The results suggested that B lymphocyte activation occurred via the formation of id-anti-id complexes, and evidence was obtained that this activation involved two separate interactions between the B lymphocytes and the id-anti-id complexes. These studies document a previously undescribed regulatory function of anti-idiotype antibodies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.132.6.2709