Search Results - "Weiss, Tilo"

Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates by Elvert, Ralf, Herling, Andreas W., Bossart, Martin, Weiss, Tilo, Zhang, Baohong, Wenski, Pierre, Wandschneider, Jörn, Kleutsch, Sabrina, Butty, Uwe, Kannt, Aimo, Wagner, Michael, Haack, Torsten, Evers, Andreas, Dudda, Angela, Lorenz, Martin, Keil, Stefanie, Larsen, Philip J.

“…Aim We performed acute and chronic studies in healthy and diet‐induced obese animals using mouse‐specific or monkey‐specific dual GLP‐1R/GCGR agonists to…”
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Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys by Elvert, Ralf, Bossart, Martin, Herling, Andreas W, Weiss, Tilo, Zhang, Baohong, Kannt, Aimo, Wagner, Michael, Haack, Torsten, Evers, Andreas, Dudda, Angela, Keil, Stefanie, Lorenz, Martin, Lorenz, Katrin, Riz, Michela, Hennerici, Wolfgang, Larsen, Philip J

“…We assessed the therapeutic contribution of the individual components of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) agonists alone…”
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Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients by Worlitzsch, Dieter, Tarran, Robert, Ulrich, Martina, Schwab, Ute, Cekici, Aynur, Meyer, Keith C., Birrer, Peter, Bellon, Gabriel, Berger, Jürgen, Weiss, Tilo, Botzenhart, Konrad, Yankaskas, James R., Randell, Scott, Boucher, Richard C., Döring, Gerd

“…Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites of bacterial infection within CF airways. Here we…”
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Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients by Worlitzsch, Dieter, Tarran, Robert, Ulrich, Martina, Schwab, Ute, Cekici, Aynur, Meyer, Keith C, Birrer, Peter, Bellon, Gabriel, Berger, Jürgen, Weiss, Tilo, Botzenhart, Konrad, Yankaskas, James R, Randell, Scott, Boucher, Richard C, Döring, Gerd

“…Current theories of CF pathogenesis predict different predisposing "local environmental" conditions and sites of bacterial infection within CF airways. Here we…”
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TNFR80-Dependent Enhancement of TNFR60-Induced Cell Death Is Mediated by TNFR-Associated Factor 2 and Is Specific for TNFR60 by Weiss, Tilo, Grell, Matthias, Siemienski, Katrin, Muhlenbeck, Frank, Durkop, Horst, Pfizenmaier, Klaus, Scheurich, Peter, Wajant, Harald

“…Costimulation of TNFR80 can strongly enhance TNFR60-induced cell death. In this study, we show that this enhancement is TNFR60 selective, as neither…”
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Large‐scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis by Aigner, Thomas, Fundel, Katrin, Saas, Joachim, Gebhard, Pia M., Haag, Jochen, Weiss, Tilo, Zien, Alexander, Obermayr, Franz, Zimmer, Ralf, Bartnik, Eckart

“…Objective Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteoarthritis (OA), including gene alterations occurring…”
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Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis by Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Li, Ziyu, Czech, Jörg, Saas, Joachim, Ding-Pfennigdorff, Danping, Dreyer, Matthias K, Strübing, Carsten, Nazare, Marc

“…The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated…”
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Cover Image, Volume 20, Issue 8 by Elvert, Ralf, Herling, Andreas W., Bossart, Martin, Weiss, Tilo, Zhang, Baohong, Wenski, Pierre, Wandschneider, Jörn, Kleutsch, Sabrina, Butty, Uwe, Kannt, Aimo, Wagner, Michael, Haack, Torsten, Evers, Andreas, Dudda, Angela, Lorenz, Martin, Keil, Stefanie, Larsen, Philip J.

“…The cover image, by Ralf Elvert, et al., is based on the Original Article Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to…”
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Discovery of N‑[4-(1H‑Pyrazolo[3,4‑b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors by Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Saas, Joachim, Li, Ziyu, Czech, Jörg, Dreyer, Matthias, Hofmeister, Armin, Mertsch, Katharina, Dietz, Uwe, Strübing, Carsten, Nazare, Marc

“…From a virtual screening starting point, inhibitors of the serum and glucocorticoid regulated kinase 1 were developed through a combination of classical…”
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Identification of High-Affinity P2Y12 Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone by Zech, Gernot, Hessler, Gerhard, Evers, Andreas, Weiss, Tilo, Florian, Peter, Just, Melitta, Czech, Jörg, Czechtizky, Werngard, Görlitzer, Jochen, Ruf, Sven, Kohlmann, Markus, Nazaré, Marc

“…A series of novel, highly potent P2Y12 antagonists as inhibitors of platelet aggregation based on a phenylpyrazole glutamic acid piperazine backbone is…”
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Identification of High-Affinity P2Y 12 Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone by Zech, Gernot, Hessler, Gerhard, Evers, Andreas, Weiss, Tilo, Florian, Peter, Just, Melitta, Czech, Jörg, Czechtizky, Werngard, Görlitzer, Jochen, Ruf, Sven, Kohlmann, Markus, Nazaré, Marc

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Dominant-negative FADD inhibits TNFR60-, Fas/Apo1-  and TRAIL-R/Apo2-mediated cell death but not gene induction by Wajant, Harald, Johannes, Franz-Josef, Haas, Elvira, Siemienski, Katrin, Schwenzer, Ralph, Schubert, Gisela, Weiss, Tilo, Grell, Matthias, Scheurich, Peter

“…Fas/Apo1 and other cytotoxic receptors of the tumor necrosis factor receptor (TNFR) family contain a cytoplasmic death domain (DD) [1–11] that activates the…”
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Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site by Weiss, T, Grell, M, Hessabi, B, Bourteele, S, Muller, G, Scheurich, P, Wajant, H

“…TNFR p60 (TNFR60) is the main mediator of TNF-induced apoptosis, although in some cells TNFR80 is also involved. TNFR80-dependent induction or enhancement of…”
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A new affinity biosensor: self-assembled thiols as selective monolayer coatings of quartz crystal microbalances by Rickert, Jan, Weiss, Tilo, Kraas, Wolfgang, Jung, Günther, Göpel, Wolfgang

“…We report on the use of quartz crystal microbalances (QCMs) for on-line detection of bioaffinity interactions. The QCM transducer is of reasonable simplicity…”
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Monolayers of Cyclopeptides: A New Concept for Molecular Recognition and Enantiomeric Discrimination by Weiß, Tilo, Leipert, Dietmar, Kaspar, Michael, Jung, Günther, Göpel, Wolfgang

“…The suitability of the combinatorial chemistry approach for the design of a broad spectrum of new molecular‐recognition compounds is demonstrated. A model…”
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Design for smelling by Gopel, W., Weiss, T.

“…On our best days-without head colds, for example-and with a time out between sniffs, we can note the presence of and distinguish among 10000 airborne molecules…”
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