Search Results - "Weiss, Thomas S"

Myristoylated PreS1‐domain of the hepatitis B virus L‐protein mediates specific binding to differentiated hepatocytes by Meier, Anja, Mehrle, Stefan, Weiss, Thomas S., Mier, Walter, Urban, Stephan

“…Chronic infection with the human hepatitis B virus (HBV) is a global health problem and a main cause of progressive liver diseases. HBV exhibits a narrow host…”
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Hepatocyte polarization is essential for the productive entry of the hepatitis B virus by Schulze, Andreas, Mills, Kerry, Weiss, Thomas S., Urban, Stephan

“…Human hepatitis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism. Within the liver, HBV replication occurs in…”
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Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways by Weiss, Thomas S, Lupke, Madeleine, Ibrahim, Sara, Buechler, Christa, Lorenz, Julia, Ruemmele, Petra, Hofmann, Ute, Melter, Michael, Dayoub, Rania

“…Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA)…”
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Does hepatic steatosis affect drug metabolizing enzymes in the liver? by Buechler, Christa, Weiss, Thomas S

“…Bioavailability and effects of xenobiotics are dependent on absorption, metabolism and elimination of the respective compounds. Hepatocytes are critically…”
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Hepatic Amyloid Beta-42-Metabolizing Proteins in Liver Steatosis and Metabolic Dysfunction-Associated Steatohepatitis by Gross, Simon, Danielyan, Lusine, Buechler, Christa, Kubitza, Marion, Klein, Kathrin, Schwab, Matthias, Melter, Michael, Weiss, Thomas S

“…Amyloid beta (Aβ) plays a major role in the pathogenesis of Alzheimer's disease and, more recently, has been shown to protect against liver fibrosis…”
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Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells by Venturelli, Sascha, Berger, Alexander, Böcker, Alexander, Busch, Christian, Weiland, Timo, Noor, Seema, Leischner, Christian, Schleicher, Sabine, Mayer, Mascha, Weiss, Thomas S., Bischoff, Stephan C., Lauer, Ulrich M., Bitzer, Michael

“…The polyphenolic alcohol resveratrol has demonstrated promising activities for the prevention and treatment of cancer. Different modes of action have been…”
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Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD by Schilcher, Katharina, Dayoub, Rania, Kubitza, Marion, Riepl, Jakob, Klein, Kathrin, Buechler, Christa, Melter, Michael, Weiss, Thomas S

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases, ranging from liver steatosis to metabolic…”
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FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells by Schuster, Susanne, Penke, Melanie, Gorski, Theresa, Gebhardt, Rolf, Weiss, Thomas S., Kiess, Wieland, Garten, Antje

“…Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the NAD salvage pathway starting from nicotinamide. Cancer cells have an increased demand…”
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Ceramide and polyunsaturated phospholipids are strongly reduced in human hepatocellular carcinoma by Krautbauer, Sabrina, Meier, Elisabeth M., Rein-Fischboeck, Lisa, Pohl, Rebekka, Weiss, Thomas S., Sigruener, Alexander, Aslanidis, Charalampos, Liebisch, Gerhard, Buechler, Christa

“…Lipid composition affects membrane function, cell proliferation and cell death and is changed in cancer tissues. Hepatocellular carcinoma (HCC) is an…”
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Interleukin-1ß Attenuates Expression of Augmenter of Liver Regeneration (ALR) by Regulating HNF4α Independent of c-Jun by Nimphy, Jonas, Ibrahim, Sara, Dayoub, Rania, Kubitza, Marion, Melter, Michael, Weiss, Thomas S

“…Inflammasomes and innate immune cells have been shown to contribute to liver injury, thereby activating Kupffer cells, which release several cytokines,…”
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Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells by Wobser, Hella, Dorn, Christoph, Weiss, Thomas S, Amann, Thomas, Bollheimer, Cornelius, Büttner, Roland, Schölmerich, Jürgen, Hellerbrand, Claus

“…Despite the initial belief that non-alcoholic fatty liver disease is a benign disorder, it is now recognized that fibrosis progression occurs in a significant…”
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GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis by Amann, Thomas, Maegdefrau, Ulrike, Hartmann, Arndt, Agaimy, Abbas, Marienhagen, Jörg, Weiss, Thomas S, Stoeltzing, Oliver, Warnecke, Christina, Schölmerich, Jürgen, Oefner, Peter J, Kreutz, Marina, Bosserhoff, Anja K, Hellerbrand, Claus

“…Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 ( GLUT1 ) gene encodes a key rate-limiting…”
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Serum Chemerin Does Not Differentiate Colorectal Liver Metastases from Hepatocellular Carcinoma by Feder, Susanne, Kandulski, Arne, Schacherer, Doris, Weiss, Thomas S, Buechler, Christa

“…The chemoattractant adipokine chemerin is related to the metabolic syndrome, which is a risk factor for different cancers. Recent studies provide evidence that…”
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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue by Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.

“…It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study…”
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis by Feder, Susanne, Wiest, Reiner, Weiss, Thomas S, Aslanidis, Charalampos, Schacherer, Doris, Krautbauer, Sabrina, Liebisch, Gerhard, Buechler, Christa

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is of particular importance in cholesterol metabolism with high levels contributing to…”
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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease by Campos, Gisela, Schmidt-Heck, Wolfgang, De Smedt, Jonathan, Widera, Agata, Ghallab, Ahmed, Pütter, Larissa, González, Daniela, Edlund, Karolina, Cadenas, Cristina, Marchan, Rosemarie, Guthke, Reinhard, Verfaillie, Catherine, Hetz, Claudio, Sachinidis, Agapios, Braeuning, Albert, Schwarz, Michael, Weiß, Thomas S., Banhart, Benjamin K., Hoek, Jan, Vadigepalli, Rajanikanth, Willy, Jeffrey, Stevens, James L., Hay, David C., Hengstler, Jan G., Godoy, Patricio

“…Inflammation has been recognized as essential for restorative regeneration. Here, we analyzed the sequential processes during onset of liver injury and…”
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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria by Gianmoena, Kathrin, Gasparoni, Nina, Jashari, Adelina, Gabrys, Philipp, Grgas, Katharina, Ghallab, Ahmed, Nordström, Karl, Gasparoni, Gilles, Reinders, Jörg, Edlund, Karolina, Godoy, Patricio, Schriewer, Alexander, Hayen, Heiko, Hudert, Christian A., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Boor, Peter, Anders, Hans-Joachim, Motrapu, Manga, Jansen, Peter, Schiergens, Tobias S., Falk-Paulsen, Maren, Rosenstiel, Philip, Lisowski, Clivia, Salido, Eduardo, Marchan, Rosemarie, Walter, Jörn, Hengstler, Jan G., Cadenas, Cristina

“…Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression and extrahepatic complications are poorly explored…”
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Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases by Berger, Alexander, Venturelli, Sascha, Kallnischkies, Mascha, Böcker, Alexander, Busch, Christian, Weiland, Timo, Noor, Seema, Leischner, Christian, Weiss, Thomas S., Lauer, Ulrich M., Bischoff, Stephan C., Bitzer, Michael

“…Kaempferol is a natural polyphenol belonging to the group of flavonoids. Different biological functions like inhibition of oxidative stress in plants or animal…”
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Hepatic Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Levels Decline in Hepatitis C but Are Not Associated with Progression of Hepatocellular Carcinoma by Weber, Florian, Utpatel, Kirsten, Evert, Katja, Weiss, Thomas S, Buechler, Christa

“…Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) is an antagonist of transforming growth factor (TGF)-β type 1 signaling. BAMBI…”
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Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα) by Thomas, Maria, Burk, Oliver, Klumpp, Britta, Kandel, Benjamin A, Damm, Georg, Weiss, Thomas S, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M

“…The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is known primarily as a regulator of fatty acid metabolism, energy balance, and…”
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