Search Results - "Weiss, Stephen"

Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation by Tang, Yi, Weiss, Stephen J.

“…Snail and Slug are zinc-finger transcription factors that play key roles in directing the epithelial-mesenchymal transition (EMT) programs associated with…”
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Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited by Sabeh, Farideh, Shimizu-Hirota, Ryoko, Weiss, Stephen J

“…Tissue invasion during metastasis requires cancer cells to negotiate a stromal environment dominated by cross-linked networks of type I collagen. Although…”
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Methionine oxidation and reduction in proteins by Kim, Geumsoo, Weiss, Stephen J., Levine, Rodney L.

“…Cysteine and methionine are the two sulfur containing amino acids in proteins. While the roles of protein-bound cysteinyl residues as endogenous antioxidants…”
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Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force by Wolf, Katarina, Te Lindert, Mariska, Krause, Marina, Alexander, Stephanie, Te Riet, Joost, Willis, Amanda L, Hoffman, Robert M, Figdor, Carl G, Weiss, Stephen J, Friedl, Peter

“…Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further…”
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Breaching the basement membrane: who, when and how? by Rowe, R. Grant, Weiss, Stephen J

“…The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells…”
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Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation by Tang, Yi, Feinberg, Tamar, Keller, Evan T., Li, Xiao-Yan, Weiss, Stephen J.

“…Bone-marrow-derived skeletal stem/stromal cell (SSC) self-renewal and function are critical to skeletal development, homeostasis and repair. Nevertheless, the…”
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In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides by Hwang, Jeongmin, Huang, Yufeng, Burwell, Timothy J, Peterson, Norman C, Connor, Jane, Weiss, Stephen J, Yu, S. Michael, Li, Yang

“…Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive proteolytic remodeling during developmental states and a variety…”
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Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease by Grande, M Teresa, Sánchez-Laorden, Berta, López-Blau, Cristina, De Frutos, Cristina A, Boutet, Agnès, Arévalo, Miguel, Rowe, R Grant, Weiss, Stephen J, López-Novoa, José M, Nieto, M Angela

“…During renal fibrosis, epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease. Progressive…”
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Navigating ECM barriers at the invasive front: the cancer cell-stroma interface by Rowe, R Grant, Weiss, Stephen J

“…A seminal event in cancer progression is the ability of the neoplastic cell to mobilize the necessary machinery to breach surrounding extracellular matrix…”
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MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis by Tang, Yi, Rowe, R. Grant, Botvinick, Elliot L., Kurup, Abhishek, Putnam, Andrew J., Seiki, Motoharu, Weaver, Valerie M., Keller, Evan T., Goldstein, Steven, Dai, Jinlu, Begun, Dana, Saunders, Thomas, Weiss, Stephen J.

“…In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation…”
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Divergent regulation of basement membrane trafficking by human macrophages and cancer cells by Bahr, Julian C., Li, Xiao-Yan, Feinberg, Tamar Y., Jiang, Long, Weiss, Stephen J.

“…Macrophages and cancer cells populations are posited to navigate basement membrane barriers by either mobilizing proteolytic enzymes or deploying mechanical…”
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Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression by Wu, Zhao-Qiu, Li, Xiao-Yan, Hu, Casey Yuexian, Ford, Michael, Kleer, Celina G, Weiss, Stephen J

“…Slug (Snail2) plays critical roles in regulating the epithelial–mesenchymal transition (EMT) programs operative during development and disease. However, the…”
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Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection by KURIHARA, Tomohiro, SHIMIZU-HIROTA, Ryoko, SHIMODA, Masayuki, ADACHI, Takeshi, SHIMIZU, Hideyuki, WEISS, Stephen J, ITOH, Hiroshi, HORI, Shingo, AIKAWA, Naoki, OKADA, Yasunori

“…Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated…”
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Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1 by Ota, Ichiro, Li, Xiao-Yan, Hu, Yuexian, Weiss, Stephen J

“…The ability of carcinoma cells arising at primary sites to cross their underlying basement membrane (BM), a specialized form of extracellular matrix that…”
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Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs by Feinberg, Tamar Y., Zheng, Huarui, Liu, Rui, Wicha, Max S., Yu, S. Michael, Weiss, Stephen J.

“…Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal…”
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An In Vitro Model of Murine Osteoclast-Mediated Bone Resorption by Sun, Xiaoyue, Wang, Zijun, Tang, Yi, Weiss, Stephen, Zhu, Lingxin

“…Osteoclasts are terminally differentiated multinucleated giant cells that mediate bone resorption and regulate skeletal homeostasis under physiological and…”
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A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition by Kim, Nam Hee, Kim, Hyun Sil, Li, Xiao-Yan, Lee, Inhan, Choi, Hyung-Seok, Kang, Shi Eun, Cha, So Young, Ryu, Joo Kyung, Yoon, Dojun, Fearon, Eric R, Rowe, R Grant, Lee, Sanghyuk, Maher, Christopher A, Weiss, Stephen J, Yook, Jong In

“…Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition (EMT) programs…”
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Increasing early infant male circumcision uptake in Zambia: Like father like son by Weiss, Stephen M, Rodriguez, Violeta J, Cook, Ryan R, Bowa, Kasonde, Zulu, Robert, Mweemba, Oliver, Kamboyi, Royd, Castro, Jose, Dunleavy, Victoria Orrego, Alcaide, Maria L, Jones, Deborah L

“…Voluntary Medical Male Circumcision (VMMC) is an effective strategy for HIV prevention in areas with high prevalence of, and risk for, HIV. More than 361,000…”
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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance by Lodillinsky, Catalina, Fuhrmann, Laetitia, Irondelle, Marie, Pylypenko, Olena, Li, Xiao-Yan, Bonsang-Kitzis, Hélène, Reyal, Fabien, Vacher, Sophie, Calmel, Claire, De Wever, Olivier, Bièche, Ivan, Lacombe, Marie-Lise, Eiján, Ana Maria, Houdusse, Anne, Vincent-Salomon, Anne, Weiss, Stephen J., Chavrier, Philippe, Boissan, Mathieu

“…Membrane Type 1 Matrix Metalloprotease (MT1-MMP) contributes to the invasive progression of breast cancers by degrading extracellular matrix tissues…”
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Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression by Sun, Chengxin, Jiang, Lin, Liu, Yan, Shen, Hong, Weiss, Stephen J., Zhou, Yifa, Rui, Liangyou

“…Lipolysis provides metabolic fuel; however, aberrant adipose lipolysis results in ectopic lipid accumulation and lipotoxicity. While adipose triacylglycerol…”
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