Search Results - "Weiss, Scott L"

Delayed Antimicrobial Therapy Increases Mortality and Organ Dysfunction Duration in Pediatric Sepsis by Weiss, Scott L, Fitzgerald, Julie C, Balamuth, Fran, Alpern, Elizabeth R, Lavelle, Jane, Chilutti, Marianne, Grundmeier, Robert, Nadkarni, Vinay M, Thomas, Neal J

“…OBJECTIVES:Delayed antimicrobials are associated with poor outcomes in adult sepsis, but data relating antimicrobial timing to mortality and organ dysfunction…”
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Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study by Weiss, Scott L, Fitzgerald, Julie C, Pappachan, John, Wheeler, Derek, Jaramillo-Bustamante, Juan C, Salloo, Asma, Singhi, Sunit C, Erickson, Simon, Roy, Jason A, Bush, Jenny L, Nadkarni, Vinay M, Thomas, Neal J

“…Limited data exist about the international burden of severe sepsis in critically ill children. To characterize the global prevalence, therapies, and outcomes…”
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Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis by Evans, Idris V. R, Phillips, Gary S, Alpern, Elizabeth R, Angus, Derek C, Friedrich, Marcus E, Kissoon, Niranjan, Lemeshow, Stanley, Levy, Mitchell M, Parker, Margaret M, Terry, Kathleen M, Watson, R. Scott, Weiss, Scott L, Zimmerman, Jerry, Seymour, Christopher W

“…IMPORTANCE: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle…”
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Developing a clinically feasible personalized medicine approach to pediatric septic shock by Wong, Hector R, Cvijanovich, Natalie Z, Anas, Nick, Allen, Geoffrey L, Thomas, Neal J, Bigham, Michael T, Weiss, Scott L, Fitzgerald, Julie, Checchia, Paul A, Meyer, Keith, Shanley, Thomas P, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J, Nowak, Jeffrey, Shekhar, Raj S, Gertz, Shira, Dawson, Emily, Howard, Kelli, Harmon, Kelli, Beckman, Eileen, Frank, Erin, Lindsell, Christopher J

“…Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining…”
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Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign–Based Electronic Alert and Bedside Clinician Identification by Balamuth, Fran, MD, PhD, Alpern, Elizabeth R., MD, MSCE, Abbadessa, Mary Kate, MSN, RN, Hayes, Katie, BS, Schast, Aileen, PhD, Lavelle, Jane, MD, Fitzgerald, Julie C., MD, PhD, Weiss, Scott L., MD, MSCE, Zorc, Joseph J., MD, MSCE

“…Study objective Recognition of pediatric sepsis is a key clinical challenge. We evaluate the performance of a sepsis recognition process including an…”
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Progressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure by Glau, Christie L, Conlon, Thomas W, Himebauch, Adam S, Yehya, Nadir, Weiss, Scott L, Berg, Robert A, Nishisaki, Akira

“…Diaphragm atrophy is associated with delayed weaning from mechanical ventilation and increased mortality in critically ill adults. We sought to test for the…”
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Frequency of and Risk Factors Associated With Hospital Readmission After Sepsis by Dashefsky, Hannah S, Liu, Hongyan, Hayes, Katie, Griffis, Heather, Vaughan, Melissa, Chilutti, Marianne, Balamuth, Fran, Stinson, Hannah R, Fitzgerald, Julie C, Carlton, Erin F, Weiss, Scott L

“…Although children who survive sepsis are at risk for readmission, identification of patient-level variables associated with readmission has been limited by…”
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Crystalloid Fluid Choice and Clinical Outcomes in Pediatric Sepsis: A Matched Retrospective Cohort Study by Weiss, Scott L., MD, MSCE, Keele, Luke, PhD, Balamuth, Fran, MD, PhD, MSCE, Vendetti, Neika, MPH, Ross, Rachael, MPH, Fitzgerald, Julie C., MD, PhD, Gerber, Jeffrey S., MD, PhD

“…Objective To test the hypothesis that resuscitation with balanced fluids (lactated Ringer [LR]) is associated with improved outcomes compared with normal…”
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J, Alder, Matthew N, Wong, Hector R

“…Abstract Background Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of…”
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Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Goldstein, Stuart L, Stanski, Natalja L

“…Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement…”
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Red Blood Cell Distribution Width as a Pragmatic Marker for Outcome in Pediatric Critical Illness by Ramby, Alexis L, Goodman, Denise M, Wald, Eric L, Weiss, Scott L

“…Red cell distribution width (RDW) is a routine laboratory measure associated with poor outcomes in adult critical illness. We determined the utility of RDW as…”
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Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R, Walley, Keith R, Standage, Stephen W

“…Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition,…”
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Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit by Lautz, Andrew J., MD, Dziorny, Adam C., MD, PhD, Denson, Adam R., CRNP, O'Connor, Kathleen A., CRNP, Chilutti, Marianne R., MS, Ross, Rachael K., MPH, Gerber, Jeffrey S., MD, PhD, Weiss, Scott L., MD, MSCE

“…Objectives To determine whether peak blood procalcitonin (PCT) measured within 48 hours of pediatric intensive care unit (PICU) admission can differentiate…”
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Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model by Wong, Hector R, Weiss, Scott L, Giuliano, Jr, John S, Wainwright, Mark S, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Chopra, Arun, Fitzgerald, Julie C, Gedeit, Rainer, Banschbach, Sharon, Beckman, Eileen, Lahni, Patrick, Hart, Kimberly, Lindsell, Christopher J

“…We previously derived and validated a risk model to estimate mortality probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk…”
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Identifying Pediatric Severe Sepsis and Septic Shock: Accuracy of Diagnosis Codes by Balamuth, Fran, MD, PhD, MSCE, Weiss, Scott L., MD, Hall, Matt, PhD, Neuman, Mark I., MD, MPH, Scott, Halden, MD, Brady, Patrick W., MD, MSc, Paul, Raina, MD, Farris, Reid W.D., MD, McClead, Richard, MD, Centkowski, Sierra, BS, Baumer-Mouradian, Shannon, MD, Weiser, Jason, BS, Hayes, Katie, BS, Shah, Samir S., MD, MSCE, Alpern, Elizabeth R., MD, MSCE

“…Objectives To evaluate accuracy of 2 established administrative methods of identifying children with sepsis using a medical record review reference standard…”
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Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis by Atkinson, Sarah J, Cvijanovich, Natalie Z, Thomas, Neal J, Allen, Geoffrey L, Anas, Nick, Bigham, Michael T, Hall, Mark, Freishtat, Robert J, Sen, Anita, Meyer, Keith, Checchia, Paul A, Shanley, Thomas P, Nowak, Jeffrey, Quasney, Michael, Weiss, Scott L, Banschbach, Sharon, Beckman, Eileen, Howard, Kelli, Frank, Erin, Harmon, Kelli, Lahni, Patrick, Lindsell, Christopher J, Wong, Hector R

“…The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. We determined associations between corticosteroids and…”
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Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein by Alqahtani, Mashael F, Smith, Craig M, Weiss, Scott L, Dawson, Susan, Ralay Ranaivo, Hantamalala, Wainwright, Mark S

“…Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic…”
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PICS-ing Up on Something Real in Pediatric Sepsis? by Weiss, Scott L

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Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza by Novak, Tanya, Crawford, Jeremy Chase, Hahn, Georg, Hall, Mark W, Thair, Simone A, Newhams, Margaret M, Chou, Janet, Mourani, Peter M, Tarquinio, Keiko M, Markovitz, Barry, Loftis, Laura L, Weiss, Scott L, Higgerson, Renee, Schwarz, Adam J, Pinto, Neethi P, Thomas, Neal J, Gedeit, Rainer G, Sanders, Jr, Ronald C, Mahapatra, Sidharth, Coates, Bria M, Cvijanovich, Natalie Z, Ackerman, Kate G, Tellez, David W, McQuillen, Patrick, Kurachek, Stephen C, Shein, Steven L, Lange, Christoph, Thomas, Paul G, Randolph, Adrienne G

“…Influenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening…”
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Implementation of a Follow-Up System for Pediatric Sepsis Survivors in a Large Academic Pediatric Intensive Care Unit by Fitzgerald, Julie C., Kelly, Nancy-Ann, Hickey, Christopher, Balamuth, Fran, Thomas, Nina H., Hogan, Annique, Stack, Noelle J., Trimarchi, Tara, Weiss, Scott L.

“…Background: Survivors of pediatric sepsis often develop new morbidities and deterioration in quality of life after sepsis, leading to a need for improved…”
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