Search Results - "Weiss, Ryan J."

Targeting heparin and heparan sulfate protein interactions by Weiss, Ryan J, Esko, Jeffrey D, Tor, Yitzhak

“…Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are made up of alternating dissacharide sequences of sulfated uronic acid…”
Get more information

Dynamical nonlinear memory capacitance in biomimetic membranes by Najem, Joseph S., Hasan, Md Sakib, Williams, R. Stanley, Weiss, Ryan J., Rose, Garrett S., Taylor, Graham J., Sarles, Stephen A., Collier, C. Patrick

“…Two-terminal memory elements, or memelements, capable of co-locating signal processing and memory via history-dependent reconfigurability at the nanoscale are…”
Get full text

PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens by Spahn, Philipp N., Bath, Tyler, Weiss, Ryan J., Kim, Jihoon, Esko, Jeffrey D., Lewis, Nathan E., Harismendy, Olivier

“…Large-scale genetic screens using CRISPR/Cas9 technology have emerged as a major tool for functional genomics. With its increased popularity, experimental…”
Get full text

ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis by Weiss, Ryan J., Spahn, Philipp N., Toledo, Alejandro Gómez, Chiang, Austin W. T., Kellman, Benjamin P., Li, Jing, Benner, Christopher, Glass, Christopher K., Gordts, Philip L. S. M., Lewis, Nathan E., Eskoa, JeffreyD

“…Heparin is the most widely prescribed biopharmaceutical in production globally. Its potent anticoagulant activity and safety makes it the drug of choice for…”
Get full text

TCAD Modeling of Resistive-Switching of HfO2 Memristors: Efficient Device-Circuit Co-Design for Neuromorphic Systems by Zeumault , Andre, Alam , Shamiul, Wood , Zack, Weiss , Ryan J., Aziz , Ahmedullah, Rose , Garrett S.

“…In neuromorphic computing, memristors (or “memory resistors”) have been primarily studied as key elements in artificial synapse implementations, where the…”
Get full text

Author Correction: Dynamical nonlinear memory capacitance in biomimetic membranes by Najem, Joseph S., Hasan, Md Sakib, Williams, R. Stanley, Weiss, Ryan J., Rose, Garrett S., Taylor, Graham J., Sarles, Stephen A., Collier, C. Patrick

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions by Weiss, Ryan J, Gordts, Philip L S M, Le, Dzung, Xu, Ding, Esko, Jeffrey D, Tor, Yitzhak

“…Surfen, bis-2-methyl-4-amino-quinolyl-6-carbamide, was previously reported as a small molecule antagonist of heparan sulfate (HS), a key cell-surface…”
Get full text

Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy by Naini, Seyedeh Maryam Alavi, Yanicostas, Constantin, Hassan-Abdi, Rahma, Blondeel, Sébastien, Bennis, Mohamed, Weiss, Ryan J, Tor, Yitzhak, Esko, Jeffrey D, Soussi-Yanicostas, Nadia

“…An amendment to this paper has been published and can be accessed via the original article…”
Get full text

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy by Alavi Naini, Seyedeh Maryam, Yanicostas, Constantin, Hassan-Abdi, Rahma, Blondeel, Sébastien, Bennis, Mohamed, Weiss, Ryan J, Tor, Yitzhak, Esko, Jeffrey D, Soussi-Yanicostas, Nadia

“…Tauopathies comprise a family of neurodegenerative disorders including Alzheimer's disease for which there is an urgent and unmet need for disease-modifying…”
Get full text

Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease by Basu, Amrita, Patel, Neil G, Nicholson, Elijah D, Weiss, Ryan J

“…Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal…”
Get more information

TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth by Basu, Amrita, Champagne, Rachel N., Patel, Neil G., Nicholson, Elijah D., Weiss, Ryan J.

“…Heparan sulfate (HS) is a long, linear polysaccharide that is ubiquitously expressed in all animal cells and plays a key role in many cellular processes,…”
Get full text

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate by Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W. T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L. S. M., Lewis, Nathan E., Esko, Jeffrey D.

“…Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment and endocytosis. These interactions depend on the…”
Get full text

Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate by Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W. T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L. S. M., Lewis, Nathan E., Esko, Jeffrey D.

Get full text

Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics by Najem, Joseph S, Taylor, Graham J, Weiss, Ryan J, Hasan, Md Sakib, Rose, Garrett, Schuman, Catherine D, Belianinov, Alex, Collier, C. Patrick, Sarles, Stephen A

“…Solid-state neuromorphic systems based on transistors or memristors have yet to achieve the interconnectivity, performance, and energy efficiency of the brain…”
Get full text

Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease by Schultheis, Nicholas, Connell, Alyssa, Kapral, Alexander, Becker, Robert J., Mueller, Richard, Shah, Shalini, O'Donnell, Mackenzie, Roseman, Matthew, Swanson, Lindsey, DeGuara, Sophia, Wang, Weihua, Yin, Fei, Saini, Tripti, Weiss, Ryan J., Selleck, Scott B.

“…We examined the function of heparan-sulfate-modified proteoglycans (HSPGs) in pathways affecting Alzheimer disease (AD)-related cell pathology in human cell…”
Get full text

Short-Term Facilitation-Then-Depression Enables Adaptive Processing of Sensory Inputs by Ion Channels in Biomolecular Synapses by Maraj, Joshua J, Najem, Joseph S, Ringley, Jessie D, Weiss, Ryan J, Rose, Garrett S, Sarles, Stephen A

“…Providing AI platforms with perceptual capabilities at low energy cost is imperative to making them more human-like. This goal is contingent on developing…”
Get full text

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes by Najem, Joseph S, Taylor, Graham J, Armendarez, Nick, Weiss, Ryan J, Hasan, Md Sakib, Rose, Garrett S, Schuman, Catherine D, Belianinov, Alex, Sarles, Stephen A, Collier, C Patrick

“…The ability to recreate synaptic functionalities in synthetic circuit elements is essential for neuromorphic computing systems that seek to emulate the…”
Get more information

Rearrangement of 3-Membered 1,1,2-Trifluorobromonium and Iodonium Ions and Comparison of Trifluorochloronium to Fluorocarbenium Ions by Shellhamer, Dale F, Davenport, Kevyn J, Forberg, Heidi K, Herrick, Matthew P, Jones, Rachel N, Rodriguez, Sean J, Sanabria, Sunamita, Trager, Nicole N, Weiss, Ryan J, Heasley, Victor L, Boatz, Jerry A

“…Reactions of chlorine (Cl2) with 4-halo-1,1,2-trifluorobut-1-enes (1, 2, or 3) give open-ion intermediates A and E that are in equilibrium. The open-chloronium…”
Get full text

Genome‐wide Screening Uncovers Transforming Growth Factor‐β3 as Regulator of Glycosaminoglycan Assembly by Rother, Sandra, Weiss, Ryan J., Esko, Jeffrey D.

“…Abstract only Heparan sulfate (HS) and chondroitin sulfate (CS) are glycosaminoglycans covalently linked to proteoglycans (PG) present on all cell surfaces and…”
Get full text

Abstract 5945: CRISPR-Cas9 dissection of heparan sulfate by Weiss, Ryan J., Spahn, Philipp N., Lewis, Nathan E., Esko, Jeffrey D.

“…Abstract Heparan sulfate proteoglycans (HSPGs) are expressed on virtually all animal cells and play important roles in tumor growth and metastasis. Each HSPG…”
Get full text