Search Results - "Weiss, Robert M"

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms by Miller, Jordan D, Weiss, Robert M, Heistad, Donald D

“…Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in…”
Get full text

Brain Interleukin-17A contributes to neuroinflammation and cardiac dysfunction in rats with myocardial infarction by Yu, Yang, Weiss, Robert M, Wei, Shun-Guang

“…Proinflammatory cytokines produced outside the central nervous system can act in the brain to promote sympathetic activation that contributes to the…”
Get full text

Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats by Yu, Yang, Wei, Shun-Guang, Weiss, Robert M., Felder, Robert B.

“…•Central inflammation contributes to neurohumoral excitation in rats with ischemia-induced heart failure (HF).•Angiotensin II induces inflammation in the…”
Get full text

Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation by Purohit, Anil, Rokita, Adam G, Guan, Xiaoqun, Chen, Biyi, Koval, Olha M, Voigt, Niels, Neef, Stefan, Sowa, Thomas, Gao, Zhan, Luczak, Elizabeth D, Stefansdottir, Hrafnhildur, Behunin, Andrew C, Li, Na, El-Accaoui, Ramzi N, Yang, Baoli, Swaminathan, Paari Dominic, Weiss, Robert M, Wehrens, Xander H.T, Song, Long-Sheng, Dobrev, Dobromir, Maier, Lars S, Anderson, Mark E

“…BACKGROUND—Atrial fibrillation (AF) is a growing public health problem without adequate therapies. Angiotensin II and reactive oxygen species are validated…”
Get full text

E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator by Guo, Ang, Wang, Yihui, Chen, Biyi, Wang, Yunhao, Yuan, Jinxiang, Zhang, Liyang, Hall, Duane, Wu, Jennifer, Shi, Yun, Zhu, Qi, Chen, Cheng, Thiel, William H, Zhan, Xin, Weiss, Robert M, Zhan, Fenghuang, Musselman, Catherine A, Pufall, Miles, Zhu, Weizhong, Au, Kin Fai, Hong, Jiang, Anderson, Mark E, Grueter, Chad E, Song, Long-Sheng

“…Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 is cleaved by the calcium…”
Get full text

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII by Luo, Min, Guan, Xiaoqun, Luczak, Elizabeth D, Lang, Di, Kutschke, William, Gao, Zhan, Yang, Jinying, Glynn, Patric, Sossalla, Samuel, Swaminathan, Paari D, Weiss, Robert M, Yang, Baoli, Rokita, Adam G, Maier, Lars S, Efimov, Igor R, Hund, Thomas J, Anderson, Mark E

“…Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown…”
Get full text

Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure by Wei, Shun-Guang, Yu, Yang, Weiss, Robert M, Felder, Robert B

“…We previously reported that endoplasmic reticulum (ER) stress is induced in the subfornical organ (SFO) and the hypothalamic paraventricular nucleus (PVN) of…”
Get more information

Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction by Yu, Yang, Weiss, Robert M, Wei, Shun-Guang

“…Elevated inflammatory cytokines in the periphery have been identified as active contributors to neuroinflammation and sympathetic overactivity in heart failure…”
Get full text

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart by Rasmussen, Tyler P, Yuejin Wu, Mei-ling A. Joiner, Olha M. Koval, Nicholas R. Wilson, Elizabeth D. Luczak, Qinchuan Wang, Biyi Chen, Zhan Gao, Zhiyong Zhu, Brett A. Wagner, Jamie Soto, Michael L. McCormick, William Kutschke, Robert M. Weiss, Liping Yu, Ryan L. Boudreau, E. Dale Abel, Fenghuang Zhan, Douglas R. Spitz, Garry R. Buettner, Long-Sheng Song, Leonid V. Zingman, Mark E. Anderson

“…Myocardial mitochondrial Ca ²⁺ entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo…”
Get full text

Sex differences in the central and peripheral manifestations of ischemia-induced heart failure in rats by Yu, Yang, Wei, Shun-Guang, Weiss, Robert M, Felder, Robert B

“…Sex differences in the presentation, outcome, and responses to treatment of systolic heart failure (HF) have been reported. In the present study, we examined…”
Get more information

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure by Zhang, Caimei, Chen, Biyi, Guo, Ang, Zhu, Yanqi, Miller, Jordan D, Gao, Shan, Yuan, Can, Kutschke, William, Zimmerman, Kathy, Weiss, Robert M, Wehrens, Xander H T, Hong, Jiang, Johnson, Frances L, Santana, Luis F, Anderson, Mark E, Song, Long-Sheng

“…BACKGROUND—Cardiac dysfunction in failing hearts of human patients and animal models is associated with both microtubule densification and transverse-tubule…”
Get full text

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress by Guo, Ang, Zhang, Xiaoying, Iyer, Venkat Ramesh, Chen, Biyi, Zhang, Caimei, Kutschke, William J., Weiss, Robert M., Franzini-Armstrong, Clara, Song, Long-Sheng

“…Heart failure is accompanied by a loss of the orderly disposition of transverse (T)-tubules and a decrease of their associations with the junctional…”
Get full text

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation by Erickson, Jeffrey R., Joiner, Mei-ling A., Guan, Xiaoqun, Kutschke, William, Yang, Jinying, Oddis, Carmine V., Bartlett, Ryan K., Lowe, John S., O'Donnell, Susan E., Aykin-Burns, Nukhet, Zimmerman, Matthew C., Zimmerman, Kathy, Ham, Amy-Joan L., Weiss, Robert M., Spitz, Douglas R., Shea, Madeline A., Colbran, Roger J., Mohler, Peter J., Anderson, Mark E.

“…Calcium/calmodulin (Ca 2+/CaM)-dependent protein kinase II (CaMKII) couples increases in cellular Ca 2+ to fundamental responses in excitable cells. CaMKII was…”
Get full text

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone by He, B Julie, Joiner, Mei-ling A, Singh, Madhu V, Luczak, Elizabeth D, Swaminathan, Paari Dominic, Koval, Olha M, Kutschke, William, Allamargot, Chantal, Yang, Jinying, Guan, Xiaoqun, Zimmerman, Kathy, Grumbach, Isabella M, Weiss, Robert M, Spitz, Douglas R, Sigmund, Curt D, Blankesteijn, W Matthijs, Heymans, Stephane, Mohler, Peter J, Anderson, Mark E

“…The hormone aldosterone can damage the heart after myocardial infarction, such that drugs that inhibit its action are often prescribed. B. Julie He et al . now…”
Get full text

MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction by Singh, Madhu V, Swaminathan, Paari D, Luczak, Elizabeth D, Kutschke, W, Weiss, Robert M, Anderson, Mark E

“…Abstract The toll-like receptors (TLR) and myocardial infarction (MI) promote NF-κB-dependent inflammatory transcription and oxidative injury in myocardium…”
Get full text

Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine by Kim, Ha Won, Blomkalns, Andra L, Ogbi, Mourad, Thomas, Manesh, Gavrila, Daniel, Neltner, Bonnie S, Cassis, Lisa A, Thompson, Robert W, Weiss, Robert M, Lindower, Paul D, Blanco, Victor M, McCormick, Michael L, Daugherty, Alan, Fu, Xiaoming, Hazen, Stanley L, Stansfield, Brian K, Huo, Yuqing, Fulton, David J, Chatterjee, Tapan, Weintraub, Neal L

“…Oxidative stress plays a fundamental role in abdominal aortic aneurysm (AAA) formation. Activated polymorphonuclear leukocytes (or neutrophils) are associated…”
Get more information

Sarcolemma-localized nNOS is required to maintain activity after mild exercise by Campbell, Kevin P, Kobayashi, Yvonne M, Rader, Erik P, Crawford, Robert W, Iyengar, Nikhil K, Thedens, Daniel R, Faulkner, John A, Parikh, Swapnesh V, Weiss, Robert M, Chamberlain, Jeffrey S, Moore, Steven A

“…Many neuromuscular conditions are characterized by an exaggerated exercise-induced fatigue response that is disproportionate to activity level. This fatigue is…”
Get full text

Calcific aortic valve stenosis in old hypercholesterolemic mice by WEISS, Robert M, OHASHI, Masuo, MILLER, Jordan D, YOUNG, Stephen G, HEISTAD, Donald D

“…Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target…”
Get full text

Sildenafil Prevents and Reverses Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension by Xie, Yu-Ping, Chen, Biyi, Sanders, Philip, Guo, Ang, Li, Yue, Zimmerman, Kathy, Wang, Lie-Cheng, Weiss, Robert M, Grumbach, Isabella M, Anderson, Mark E, Song, Long-Sheng

“…Right ventricular (RV) failure (RVF) is the main cause of death in patients with pulmonary artery hypertension (PAH). Sildenafil, a phosphodiesterase type 5…”
Get full text

Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats by Yu, Yang, Xue, Baojian, Irfan, Nafis Md, Beltz, Terry, Weiss, Robert M, Johnson, Alan Kim, Felder, Robert B, Wei, Shun-Guang

“…Tumor necrosis factor (TNF)-α converting enzyme (TACE) is a key metalloprotease mediating ectodomain shedding of a variety of inflammatory mediators,…”
Get full text