Search Results - "Weiss, Lauren A."

Recurrent reciprocal copy number variants: Roles and rules in neurodevelopmental disorders by Deshpande, Aditi, Weiss, Lauren A.

“…ABSTRACT Deletions and duplications, called reciprocal CNVs when they occur at the same locus, are implicated in neurodevelopmental phenotypes ranging from…”
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Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits by Vysotskiy, Mikhail, Weiss, Lauren A

“…The 16p11.2 and 22q11.2 copy number variants (CNVs) are associated with neurobehavioral traits including autism spectrum disorder (ASD), schizophrenia, bipolar…”
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Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes by Song, Michael, Yang, Xiaoyu, Ren, Xingjie, Maliskova, Lenka, Li, Bingkun, Jones, Ian R., Wang, Chao, Jacob, Fadi, Wu, Kenneth, Traglia, Michela, Tam, Tsz Wai, Jamieson, Kirsty, Lu, Si-Yao, Ming, Guo-Li, Li, Yun, Yao, Jun, Weiss, Lauren A., Dixon, Jesse R., Judge, Luke M., Conklin, Bruce R., Song, Hongjun, Gan, Li, Shen, Yin

“…Mutations in gene regulatory elements have been associated with a wide range of complex neuropsychiatric disorders. However, due to their cell-type specificity…”
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SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs) by Abrahams, Brett S, Arking, Dan E, Campbell, Daniel B, Mefford, Heather C, Morrow, Eric M, Weiss, Lauren A, Menashe, Idan, Wadkins, Tim, Banerjee-Basu, Sharmila, Packer, Alan

“…New technologies enabling genome-wide interrogation have led to a large and rapidly growing number of autism spectrum disorder (ASD) candidate genes. Although…”
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Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder by Deshpande, Aditi, Yadav, Smita, Dao, Dang Q., Wu, Zhi-Yong, Hokanson, Kenton C., Cahill, Michelle K., Wiita, Arun P., Jan, Yuh-Nung, Ullian, Erik M., Weiss, Lauren A.

“…A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In…”
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Sex-heterogeneous SNPs disproportionately influence gene expression and health by Traglia, Michela, Bout, Margaux, Weiss, Lauren A

“…Phenotypic differences across sexes are pervasive, but the genetic architecture of sex differences within and across phenotypes is mostly unknown. In this…”
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Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? by Dougherty, Joseph D., Marrus, Natasha, Maloney, Susan E., Yip, Benjamin, Sandin, Sven, Turner, Tychele N., Selmanovic, Din, Kroll, Kristen L., Gutmann, David H., Constantino, John N., Weiss, Lauren A.

“…Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a “female protective effect” (FPE) envisions males and females have…”
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The sex-specific genetic architecture of quantitative traits in humans by Ober, Carole, Weiss, Lauren A, Pan, Lin, Abney, Mark

“…Mapping genetically complex traits remains one of the greatest challenges in human genetics today. In particular, gene-environment and gene-gene interactions,…”
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Association between Microdeletion and Microduplication at 16p11.2 and Autism by Weiss, Lauren A, Shen, Yiping, Korn, Joshua M, Arking, Dan E, Miller, David T, Fossdal, Ragnheidur, Saemundsen, Evald, Stefansson, Hreinn, Stefansson, Kari, Ferreira, Manuel A.R, Green, Todd, Platt, Orah S, Ruderfer, Douglas M, Walsh, Christopher A, Altshuler, David, Chakravarti, Aravinda, Tanzi, Rudolph E, Santangelo, Susan L, Gusella, James F, Sklar, Pamela, Wu, Bai-Lin, Daly, Mark J

“…The causes of autism are largely unknown. This study establishes that aberrant dosage of a large genomic segment is associated with autism spectrum disorder…”
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Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells by Bershteyn, Marina, Hayashi, Yohei, Desachy, Guillaume, Hsiao, Edward C., Sami, Salma, Tsang, Kathryn M., Weiss, Lauren A., Kriegstein, Arnold R., Yamanaka, Shinya, Wynshaw-Boris, Anthony

“…Generation of human induced pluripotent stem cells from patient fibroblasts containing ring chromosomes with large deletions reveals that reprogrammed cells…”
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Dysregulation of astrocyte extracellular signaling in Costello syndrome by Krencik, Robert, Hokanson, Kenton C, Narayan, Aditi R, Dvornik, Jill, Rooney, Gemma E, Rauen, Katherine A, Weiss, Lauren A, Rowitch, David H, Ullian, Erik M

“…Astrocytes produce an assortment of signals that promote neuronal maturation according to a precise developmental timeline. Is this orchestrated timing and…”
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Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders by Mitra, Ileena, Lavillaureix, Alinoë, Yeh, Erika, Traglia, Michela, Tsang, Kathryn, Bearden, Carrie E, Rauen, Katherine A, Weiss, Lauren A

“…Although gene-gene interaction, or epistasis, plays a large role in complex traits in model organisms, genome-wide by genome-wide searches for two-way…”
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Pleiotropic Mechanisms Indicated for Sex Differences in Autism by Mitra, Ileena, Tsang, Kathryn, Ladd-Acosta, Christine, Croen, Lisa A, Aldinger, Kimberly A, Hendren, Robert L, Traglia, Michela, Lavillaureix, Alinoë, Zaitlen, Noah, Oldham, Michael C, Levitt, Pat, Nelson, Stanley, Amaral, David G, Hertz-Picciotto, Irva, Fallin, M Daniele, Weiss, Lauren A

“…Sexual dimorphism in common disease is pervasive, including a dramatic male preponderance in autism spectrum disorders (ASDs). Potential genetic explanations…”
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Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes by Vysotskiy, Mikhail, Zhong, Xue, Miller-Fleming, Tyne W, Zhou, Dan, Cox, Nancy J, Weiss, Lauren A

“…Deletions and duplications of the multigenic 16p11.2 and 22q11.2 copy number variant (CNV) regions are associated with brain-related disorders including…”
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Ratio of n--6 to n--3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study by Weiss, L.A, Barrett-Connor, E, Von Muhlen, D

“…Background: Several lines of evidence suggest that n-3 fatty acids reduce the risk of some chronic diseases, including heart disease, diabetes, and cancer…”
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Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease by Fass, Stuart B, Mulvey, Bernard, Chase, Rebecca, Yang, Wei, Selmanovic, Din, Chaturvedi, Sneha M, Tycksen, Eric, Weiss, Lauren A, Dougherty, Joseph D

“…Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. In order to understand the…”
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Cross-genetic determination of maternal and neonatal immune mediators during pregnancy by Traglia, Michela, Croen, Lisa A, Jones, Karen L, Heuer, Luke S, Yolken, Robert, Kharrazi, Martin, DeLorenze, Gerald N, Ashwood, Paul, Van de Water, Judy, Weiss, Lauren A

“…The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators…”
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A genome-wide survey of transgenerational genetic effects in autism by Tsang, Kathryn M, Croen, Lisa A, Torres, Anthony R, Kharrazi, Martin, Delorenze, Gerald N, Windham, Gayle C, Yoshida, Cathleen K, Zerbo, Ousseny, Weiss, Lauren A

“…Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However, these…”
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Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders by Croen, Lisa A, Ames, Jennifer L, Qian, Yinge, Alexeeff, Stacey, Ashwood, Paul, Gunderson, Erica P, Wu, Yvonne W, Boghossian, Andrew S, Yolken, Robert, Van de Water, Judy, Weiss, Lauren A

“…Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with inflammation during…”
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Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes by Josowitz, Rebecca, Mulero-Navarro, Sonia, Rodriguez, Nelson A., Falce, Christine, Cohen, Ninette, Ullian, Erik M., Weiss, Lauren A., Rauen, Katherine A., Sobie, Eric A., Gelb, Bruce D.

“…Germline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role of the…”
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