Search Results - "Weiss, Blaine"

Elevated calcineurin activity in primary astrocytes leads to the dephosphorylation of connexin 43 in conjunction with increased membrane permeability by Weiss, Blaine E, Kraner, Susan D, Artiushin, Irina A, Norris, Christopher M

“…Hyperactivation of the Ca2+/calmodulin-dependent phosphatase calcineurin (CN) is observed in reactive astrocytes associated with neuroinflammation and…”
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Tau drives translational selectivity by interacting with ribosomal proteins by Koren, Shon A., Hamm, Matthew J., Meier, Shelby E., Weiss, Blaine E., Nation, Grant K., Chishti, Emad A., Arango, Juan Pablo, Chen, Jing, Zhu, Haining, Blalock, Eric M., Abisambra, Jose F.

“…There is a fundamental gap in understanding the consequences of tau–ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and…”
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Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease by Sompol, Pradoldej, Gollihue, Jenna L, Weiss, Blaine E, Lin, Ruei-Lung, Case, Sami L, Kraner, Susan D, Weekman, Erica M, Gant, John C, Rogers, Colin B, Niedowicz, Dana M, Sudduth, Tiffany L, Powell, David K, Lin, Ai-Ling, Nelson, Peter T, Thibault, Olivier, Wilcock, Donna M, Norris, Christopher M

“…Despite the indispensable role that astrocytes play in the neurovascular unit, few studies have investigated the functional impact of astrocyte signaling in…”
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Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model by MacPherson, Kathryn P, Eidson, Lori N, Houser, Madelyn C, Weiss, Blaine E, Gollihue, Jenna L, Herrick, Mary K, de Sousa Rodrigues, Maria Elizabeth, Sniffen, Lindsey, Weekman, Erica M, Hamilton, Adam M, Kelly, Sean D, Oliver, Danielle L, Yang, Yuan, Chang, Jianjun, Sampson, Timothy R, Norris, Christopher M, Tansey, Malú Gámez

“…Increasing evidence indicates that neurodegenerative diseases, including Alzheimer's disease (AD), are a product of gene-by-environment interplay. The immune…”
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Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach by Fontaine, Sarah N, Ingram, Alexandria, Cloyd, Ryan A, Meier, Shelby E, Miller, Emily, Lyons, Danielle, Nation, Grant K, Mechas, Elizabeth, Weiss, Blaine, Lanzillotta, Chiara, Di Domenico, Fabio, Schmitt, Frederick, Powell, David K, Vandsburger, Moriel, Abisambra, Jose F

“…Abstract Tauopathies, the most common of which is Alzheimer’s disease (AD), constitute the most crippling neurodegenerative threat to our aging population…”
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Astrocyte calcium dysregulation and cerebrovascular impairments in the 5XFAD mouse model of familial Alzheimer’s disease by Weiss, Blaine E., Gant, John C, Sompol, Pradoldej, Thibault, Olivier, Kraner, Susan D., Norris, Christopher M.

“…Background Amyloid deposits (Aβ) in the brain are a primary diagnostic marker of Alzheimer’s disease, and are associated with the degeneration of synapses and…”
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Astrocyte Ca2+ dysregulation and neurovascular coupling deficits in a diet‐based mouse model of small cerebral vessel disease by Weiss, Blaine E., Sompol, Pradoldej M, Gant, John C, Lin, Ruei‐Lung, Nelson, Peter T, Thibault, Olivier, Wilcock, Donna M., Norris, Christopher M.

“…Background Mice exposed to a diet deficient in B6/B12 vitamins and enriched in methionine exhibit hyperhomocysteinemia (HHcy) concomitant with many pathologic…”
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Development of monoclonal antibodies specific for the calpain‐generated ∆48 kDa calcineurin fragment, a marker of distressed astrocytes: Molecular and cell biology/calcium homeostasis by Gollihue, Jenna L., Kraner, Susan D., Weiss, Blaine E., Artiushin, Irina A., Sompol, Pradoldej, Norris, Christopher M.

“…Abstract Background Calcineurin (CN) is a Ca2+/calmodulin‐dependent protein phosphatase expressed at high levels in brain. In healthy tissue, CN exists mainly…”
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Development of monoclonal antibodies specific for the calpain‐generated ∆48 kDa calcineurin fragment, a marker of distressed astrocytes by Gollihue, Jenna L., Kraner, Susan D., Weiss, Blaine E., Artiushin, Irina A., Sompol, Pradoldej, Norris, Christopher M.

“…Background Calcineurin (CN) is a Ca2+/calmodulin‐dependent protein phosphatase expressed at high levels in brain. In healthy tissue, CN exists mainly as a…”
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Perturbed astrocyte Ca2+ signaling in a diet‐based mouse model of small cerebral vessel disease by Norris, Christopher M, Sompol, Pradoldej M, Weiss, Blaine E., Gant, Christopher C, Wilcock, Donna M, Lin, Ruei‐Lung, Thibault, Olivier

“…Background The hyperhomocysteinemia (HHcy) diet model of small cerebral vessel disease exhibits vascular inflammation, cerebral hypoperfusion, impaired…”
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Synaptoprotective effects of the novel TNF inhibitor XPRO1595 in 5xFAD mice: Interactions between Western diet and sex by Weiss, Blaine E., Gollihue, Jenna L., Farr, N. Drew, Sompol, Pradoldej, Artiushin, Irina A., Kraner, Susan D., Tansey, Malu Gamez, Norris, Christopher M.

“…Background The western diet has been repeatedly shown to trigger inflammation and has been implicated as an environmental factor in cerebrovascular disease and…”
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Synaptoprotective effects of the novel TNF inhibitor XPRO1595 in 5xFAD mice: Interactions between Western diet and sex: Molecular and cell biology/neuroinflammation by Weiss, Blaine E., Gollihue, Jenna L., Farr, N. Drew, Sompol, Pradoldej, Artiushin, Irina A., Kraner, Susan D., Tansey, Malu Gamez, Norris, Christopher M.

“…Abstract Background The western diet has been repeatedly shown to trigger inflammation and has been implicated as an environmental factor in cerebrovascular…”
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Astrocyte activation and neurovascular function in a diet‐based model of vascular contributions to cognitive impairment and dementia (VCID): Molecular and cell biology/vascular factors by Sompol, Pradoldej, Edelmann, Stephanie E., Lin, Ruei‐Lung, Gant, Christopher C., Kraner, Susan D., Weiss, Blaine E., Farr, N. Drew, Gollihue, Jenna L., Thibault, Olivier, Wilcock, Donna M., Norris, Christopher M.

“…Abstract Background Vascular contributions to cognitive impairment and dementia (VCID) are highly comorbid with Alzheimer’s disease (AD) pathology and may…”
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Astrocyte activation and neurovascular function in a diet‐based model of vascular contributions to cognitive impairment and dementia (VCID) by Sompol, Pradoldej, Edelmann, Stephanie E., Lin, Ruei‐Lung, Gant, Christopher C., Kraner, Susan D., Weiss, Blaine E., Farr, N. Drew, Gollihue, Jenna L., Thibault, Olivier, Wilcock, Donna M., Norris, Christopher M.

“…Background Vascular contributions to cognitive impairment and dementia (VCID) are highly comorbid with Alzheimer’s disease (AD) pathology and may accelerate…”
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Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease by Gusareva, Elena S., Twizere, Jean-Claude, Sleegers, Kristel, Dourlen, Pierre, Abisambra, Jose F., Meier, Shelby, Cloyd, Ryan, Weiss, Blaine, Dermaut, Bart, Bessonov, Kyrylo, van der Lee, Sven J., Carrasquillo, Minerva M., Katsumata, Yuriko, Cherkaoui, Majid, Asselbergh, Bob, Ikram, M. Arfan, Mayeux, Richard, Farrer, Lindsay A., Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Sims, Rebecca, Williams, Julie, Amouyel, Philippe, van Duijn, Cornelia M., Ertekin-Taner, Nilüfer, Van Broeckhoven, Christine, Dequiedt, Franck, Fardo, David W., Lambert, Jean-Charles, Van Steen, Kristel

“…Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a…”
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O5‐04‐06: TAU ASSOCIATES WITH RIBOSOMAL PROTEINS SHIFTING THE TRANSLATOME by Koren, Shon, Hamm, Matthew, Meier, Shelby E., Weiss, Blaine, Nation, Grant K., Chishti, Emad, Arango, Juan P., Chen, Jing, Zhu, Haining, Blalock, Eric, Abisambra, Jose

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TAU ASSOCIATES WITH RIBOSOMAL PROTEINS SHIFTING THE TRANSLATOME by Koren, Shon, Hamm, Matthew, Meier, Shelby E., Weiss, Blaine, Nation, Grant K., Chishti, Emad, Arango, Juan P., Chen, Jing, Zhu, Haining, Blalock, Eric, Abisambra, Jose

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O1‐06‐04: A DYNAMIC PERK‐TAU COMPLEX REGULATES TAU PHOSPHORYLATION, ER STRESS, AND TREATMENT OUTCOMES IN RTG4510 MICE by Fontaine, Sarah N., Nation, Grant K., Koren, Shon, Weiss, Blaine, Cloyd, Ryan, Meier, Shelby E., Chishti, Emad, Powell, David K., Vandsburger, Moriel, Abisambra, Joe F.

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A DYNAMIC PERK-TAU COMPLEX REGULATES TAU PHOSPHORYLATION, ER STRESS, AND TREATMENT OUTCOMES IN RTG4510 MICE by Fontaine, Sarah N., Nation, Grant K., Koren, Shon, Weiss, Blaine, Cloyd, Ryan, Meier, Shelby E., Chishti, Emad, Powell, David K., Vandsburger, Moriel, Abisambra, Joe F.

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Cocaine-Induced Mood Disorder: Prevalence Rates and Psychiatric Symptoms in an Outpatient Cocaine-Dependent Sample by Siqueland, Amanda Horn, Karla Moras, George Woody, Roger Weiss, Jack Blaine, Sarah Bishop, Jacques Barber, Michael Thase, Lynne

“…This paper attempts to examine and compare prevalence rates and symptom patterns of DSM substance-induced and other mood disorders. 243 cocaine-dependent…”
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