Highly parallel DNA-programmed combinatorial chemistry
The abilities to modulate and observe protein function are invaluable tools in biology and medicine, and small molecules are well-suited to these functions; however, molecular discovery efforts have been hindered by the time and resources necessary to produce and screen compound collections. At the...
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| Format: | Dissertation |
| Language: | English |
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ProQuest Dissertations & Theses
01-01-2011
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| Online Access: | Get full text |
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| Summary: | The abilities to modulate and observe protein function are invaluable tools in biology and medicine, and small molecules are well-suited to these functions; however, molecular discovery efforts have been hindered by the time and resources necessary to produce and screen compound collections. At the same time, functional ligands have been evolved from libraries of nucleic acids, peptides, and proteins, and the in vitro evolution of biopolymers has been demonstrated to be inexpensive, practicable by academic labs, and general. DNA-programmed synthetic methods extend these techniques to select organic molecules and can thus exploit the many attractive properties of small molecules, including their vast chemical diversity. We present a platform for DNA-directed chemistry that allows for the synthesis of large libraries of drug-like compounds, specifically 21 billion capped tripeptoids, along with a method for the selection of protein kinase substrates from that library. |
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| ISBN: | 1124571531 9781124571539 |