Search Results - "Weisenhorn, Daniela M Vogt"

Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons by Giehrl‐Schwab, Jessica, Giesert, Florian, Rauser, Benedict, Lao, Chu Lan, Hembach, Sina, Lefort, Sandrine, Ibarra, Ignacio L, Koupourtidou, Christina, Luecken, Malte Daniel, Truong, Dong‐Jiunn Jeffery, Fischer‐Sternjak, Judith, Masserdotti, Giacomo, Prakash, Nilima, Ninkovic, Jovica, Hölter, Sabine M, Vogt Weisenhorn, Daniela M, Theis, Fabian J, Götz, Magdalena, Wurst, Wolfgang

“…Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For…”
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A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease by Schmidt, Sebastian, Stautner, Constantin, Vu, Duc Tung, Heinz, Alexander, Regensburger, Martin, Karayel, Ozge, Trümbach, Dietrich, Artati, Anna, Kaltenhäuser, Sabine, Nassef, Mohamed Zakaria, Hembach, Sina, Steinert, Letyfee, Winner, Beate, Jürgen, Winkler, Jastroch, Martin, Luecken, Malte D., Theis, Fabian J., Westmeyer, Gil Gregor, Adamski, Jerzy, Mann, Matthias, Hiller, Karsten, Giesert, Florian, Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction…”
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A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/− mice by Zhang, Jingzhong, Götz, Sebastian, Vogt Weisenhorn, Daniela M, Simeone, Antonio, Wurst, Wolfgang, Prakash, Nilima

“…Abstract The protracted and age-dependent degeneration of dopamine (DA)-producing neurons of the Substantia nigra pars compacta (SNc) and ventral tegmental…”
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PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation by Lind-Holm Mogensen, Frida, Sousa, Carole, Ameli, Corrado, Badanjak, Katja, Pereira, Sandro L, Muller, Arnaud, Kaoma, Tony, Coowar, Djalil, Scafidi, Andrea, Poovathingal, Suresh K, Tziortziou, Maria, Antony, Paul M A, Nicot, Nathalie, Ginolhac, Aurélien, Vogt Weisenhorn, Daniela M, Wurst, Wolfgang, Poli, Aurélie, Nazarov, Petr V, Skupin, Alexander, Grünewald, Anne, Michelucci, Alessandro

“…Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson's disease (PD)…”
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FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum by Meier, Florian, Giesert, Florian, Delic, Sabit, Faus-Kessler, Theresa, Matheus, Friederike, Simeone, Antonio, Hölter, Sabine M, Kühn, Ralf, Weisenhorn, Daniela M Vogt, Wurst, Wolfgang, Prakash, Nilima

“…The normal cellular organization and layering of the vertebrate cerebellum is established during embryonic and early postnatal development by the interplay of…”
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A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo by Prakash, Nilima, Brodski, Claude, Naserke, Thorsten, Puelles, Eduardo, Gogoi, Robindra, Hall, Anita, Panhuysen, Markus, Echevarria, Diego, Sussel, Lori, Weisenhorn, Daniela M Vogt, Martinez, Salvador, Arenas, Ernest, Simeone, Antonio, Wurst, Wolfgang

“…Midbrain neurons synthesizing the neurotransmitter dopamine play a central role in the modulation of different brain functions and are associated with major…”
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Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?” by Schmidt, Sebastian, Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Parkinson's disease (PD) is a still incurable neurodegenerative disorder with a highly complex etiology. While about 10% of cases are associated with…”
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Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb by Glasl, Lisa, Kloos, Karina, Giesert, Florian, Roethig, Anne, Di Benedetto, Barbara, Kühn, Ralf, Zhang, Jingzhong, Hafen, Ulrich, Zerle, Julia, Hofmann, Andreas, Hrabé de Angelis, Martin, Winklhofer, Konstanze F., Hölter, Sabine M., Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1…”
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Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors by Bus, Christine, Zizmare, Laimdota, Feldkaemper, Marita, Geisler, Sven, Zarani, Maria, Schaedler, Anna, Klose, Franziska, Admard, Jakob, Mageean, Craig J., Arena, Giuseppe, Fallier-Becker, Petra, Ugun-Klusek, Aslihan, Maruszczak, Klaudia K., Kapolou, Konstantina, Schmid, Benjamin, Rapaport, Doron, Ueffing, Marius, Casadei, Nicolas, Krüger, Rejko, Gasser, Thomas, Vogt Weisenhorn, Daniela M., Kahle, Philipp J., Trautwein, Christoph, Gloeckner, Christian J., Fitzgerald, Julia C.

“…PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the…”
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A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons by Zhang, Jingzhong, Giesert, Florian, Kloos, Karina, Vogt Weisenhorn, Daniela M, Aigner, Ludwig, Wurst, Wolfgang, Couillard-Despres, Sebastien

“…Lack of appropriate tools and techniques to study fate and functional integration of newly generated neurons has so far hindered understanding of neurogenesis'…”
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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool by Piccoli, Giovanni, Condliffe, Steven B, Bauer, Matthias, Giesert, Florian, Boldt, Karsten, De Astis, Silvia, Meixner, Andrea, Sarioglu, Hakan, Vogt-Weisenhorn, Daniela M, Wurst, Wolfgang, Gloeckner, Christian Johannes, Matteoli, Michela, Sala, Carlo, Ueffing, Marius

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in…”
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Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease by Schmidt, Sebastian, Luecken, Malte D., Trümbach, Dietrich, Hembach, Sina, Niedermeier, Kristina M., Wenck, Nicole, Pflügler, Klaus, Stautner, Constantin, Böttcher, Anika, Lickert, Heiko, Ramirez-Suastegui, Ciro, Ahmad, Ruhel, Ziller, Michael J., Fitzgerald, Julia C., Ruf, Viktoria, van de Berg, Wilma D. J., Jonker, Allert J., Gasser, Thomas, Winner, Beate, Winkler, Jürgen, Vogt Weisenhorn, Daniela M., Giesert, Florian, Theis, Fabian J., Wurst, Wolfgang

“…Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological…”
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Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain-Hindbrain Organizer by Brodski, Claude, Weisenhorn, Daniela M. Vogt, Signore, Massimo, Sillaber, Inge, Oesterheld, Matthias, Broccoli, Vania, Acampora, Dario, Simeone, Antonio, Wurst, Wolfgang

“…Midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric…”
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Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain by Blak, Alexandra A., Naserke, Thorsten, Saarimäki-Vire, Jonna, Peltopuro, Paula, Giraldo-Velasquez, Mario, Vogt Weisenhorn, Daniela M., Prakash, Nilima, Sendtner, Michael, Partanen, Juha, Wurst, Wolfgang

“…The mid-/hindbrain organizer (MHO) is characterized by the expression of a network of genes, which controls the patterning and development of the prospective…”
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A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli by Giusti, Sebastian A, Pino, Natalia S, Pannunzio, Camila, Ogando, Mora B, Armando, Natalia G, Garrett, Lillian, Zimprich, Annemarie, Becker, Lore, Gimeno, Maria L, Lukin, Jeronimo, Merino, Florencia L, Pardi, M Belen, Pedroncini, Olivia, Di Mauro, Giuliana C, Durner, Valerie Gailus, Fuchs, Helmut, de Angelis, Martin Hrabe, Patop, Ines L, Turck, Christoph W, Deussing, Jan M, Vogt Weisenhorn, Daniela M, Jahn, Olaf, Kadener, Sebastian, Hölter, Sabine M, Brose, Nils, Giesert, Florian, Wurst, Wolfgang, Marin-Burgin, Antonia, Refojo, Damian

“…Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of…”
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Fibroblast Growth Factor Receptors Cooperate to Regulate Neural Progenitor Properties in the Developing Midbrain and Hindbrain by Saarimaki-Vire, Jonna, Peltopuro, Paula, Lahti, Laura, Naserke, Thorsten, Blak, Alexandra A, Vogt Weisenhorn, Daniela M, Yu, Kai, Ornitz, David M, Wurst, Wolfgang, Partanen, Juha

“…Fibroblast growth factors (FGFs) secreted from the midbrain-rhombomere 1 (r1) boundary instruct cell behavior in the surrounding neuroectoderm. For example, a…”
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Structural Determinants of the C-terminal Helix-Kink-Helix Motif Essential for Protein Stability and Survival Promoting Activity of DJ-1 by Görner, Karin, Holtorf, Eve, Waak, Jens, Pham, Thu-Trang, Vogt-Weisenhorn, Daniela M., Wurst, Wolfgang, Haass, Christian, Kahle, Philipp J.

“…Mutations in the PARK7 gene encoding DJ-1 cause autosomal recessive Parkinson disease. The most deleterious point mutation is the L166P substitution, which…”
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Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region by Panhuysen, Markus, Vogt Weisenhorn, Daniela M, Blanquet, Veronique, Brodski, Claude, Heinzmann, Ulrich, Beisker, Wolfgang, Wurst, Wolfgang

“…The secreted glycoprotein WNT1 is expressed in the caudal midbrain and is essential for proper development of the entire mid-/hindbrain region. To get better…”
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Activation of ERK MAPK in the Lateral Amygdala of the Mouse is Required for Acquisition of a Fear-Potentiated Startle response by DI BENEDETTO, Barbara, KALLNIK, Magdalena, VOGT WEISENHORN, Daniela M, FALLS, William A, WURST, Wolfgang, HÖLTER, Sabine M

“…There is considerable interest in examining the genes that may contribute to anxiety. We examined the function of ERK/MAPK in the acquisition of conditioned…”
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Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain by Di Benedetto, Barbara, Hitz, Christiane, Hölter, Sabine M., Kühn, Ralf, Vogt Weisenhorn, Daniela M., Wurst, Wolfgang

“…The mitogen‐activated protein kinases (MAPKs), also called extracellular signal‐regulated kinases (ERKs), are a group of serine/threonine terminal protein…”
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