Search Results - "Weis, Victoria G"

Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia After Acute Loss of Parietal Cells by Petersen, Christine P, Weis, Victoria G, Nam, Ki Taek, Sousa, Josane F, Fingleton, Barbara, Goldenring, James R

“…Background & Aims Loss of parietal cells causes the development of spasmolytic polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief…”
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Current understanding of SPEM and its standing in the preneoplastic process by Weis, Victoria G., Goldenring, James R.

“…Gastric cancer is the second leading cause of cancer-related death worldwide, but the details of gastric carcinogenesis remain unclear. In humans, two…”
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Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes by Knowles, Byron C, Weis, Victoria G, Yu, Shiyan, Roland, Joseph T, Williams, Janice A, Alvarado, Gabriela S, Lapierre, Lynne A, Shub, Mitchell D, Gao, Nan, Goldenring, James R

“…Rab11a is a key component of the apical recycling endosome that aids in the trafficking of proteins to the luminal surface in polarized epithelial cells…”
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Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach by Weis, Victoria G, Petersen, Christine P, Mills, Jason C, Tuma, Pamela L, Whitehead, Robert H, Goldenring, James R

“…Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of…”
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Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal Duodenum by Weis, Victoria G, Knowles, Byron C, Choi, Eunyoung, Goldstein, Anna E, Williams, Janice A, Manning, Elizabeth H, Roland, Joseph T, Lapierre, Lynne A, Goldenring, James R

“…Background & Aims Inactivating mutations in myosin Vb (MYO5B) cause severe neonatal diarrhea in microvillus inclusion disease. Loss of active MYO5B causes the…”
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The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage by Bredemeyer, Andrew J., Geahlen, Jessica H., Weis, Victoria G., Huh, Won Jae, Zinselmeyer, Bernd H., Srivatsan, Subhashini, Miller, Mark J., Shaw, Andrey S., Mills, Jason C.

“…In the mammalian gastrointestinal tract, the cell fate decisions that specify the development of multiple, diverse lineages are governed in large part by…”
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Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis by Weis, Victoria G, Deal, Anna C, Mekkey, Gehad, Clouse, Cara, Gaffley, Michaela, Whitaker, Emily, Peeler, Cole B, Weis, Jared A, Schwartz, Marshall Z, Atala, Anthony

“…Necrotizing enterocolitis (NEC), a life-threatening intestinal disease, is becoming a larger proportionate cause of morbidity and mortality in premature…”
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Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl– Secretion in Enterocytes by Engevik, Amy C., Kaji, Izumi, Engevik, Melinda A., Meyer, Anne R., Weis, Victoria G., Goldstein, Anna, Hess, Michael W., Müller, Thomas, Koepsell, Hermann, Dudeja, Pradeep K., Tyska, Matthew, Huber, Lukas A., Shub, Mitchell D., Ameen, Nadia, Goldenring, James R.

“…Inactivating mutations in MYO5B cause microvillus inclusion disease (MVID), but the physiological cause of the diarrhea associated with this disease is…”
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Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach by Nam, Ki Taek, Lee, Hyuk–Joon, Sousa, Josane F, Weis, Victoria G, O'Neal, Ryan L, Finke, Paul E, Romero–Gallo, Judith, Shi, Guanglu, Mills, Jason C, Peek, Richard M, Konieczny, Stephen F, Goldenring, James R

“…Background & Aims Gastric cancer evolves in the setting of a pathologic mucosal milieu characterized by both loss of acid-secreting parietal cells and mucous…”
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Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis by Weis, Jared A, Rauh, Jessica L, Ellison, Maryssa A, Cruz-Diaz, Nildris, Yamaleyeva, Liliya M, Welch, Cherrie D, Zeller, Kristen A, Weis, Victoria G

“…Necrotizing enterocolitis (NEC) is an often-lethal disease of the premature infant intestinal tract, exacerbated by significant diagnostic difficulties. In…”
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Photoacoustic Imaging as a Novel Non-invasive Biomarker to Assess Intestinal Tissue Oxygenation and Motility in Neonatal Rats by Weis, Victoria G., Cruz-Diaz, Nildris, Rauh, Jessica L., Ellison, Maryssa A., Yamaleyeva, Liliya M., Welch, Cherrie D., Zeller, Kristen A., Weis, Jared A.

“…Within the premature infant intestine, oxygenation and motility play key physiological roles in healthy development and disease such as necrotizing…”
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Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression by Weis, Victoria G, Sousa, Josane F, LaFleur, Bonnie J, Nam, Ki Taek, Weis, Jared A, Finke, Paul E, Ameen, Nadia A, Fox, James G, Goldenring, James R

“…Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To…”
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Maturity and age influence chief cell ability to transdifferentiate into metaplasia by Weis, Victoria G, Petersen, Christine P, Weis, Jared A, Meyer, Anne R, Choi, Eunyoung, Mills, Jason C, Goldenring, James R

“…The plasticity of gastric chief cells is exemplified by their ability to transdifferentiate into spasmolytic polypeptide-expressing metaplasia (SPEM) after…”
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Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease by Schlegel, Cameron, Weis, Victoria G., Knowles, Byron C., Lapierre, Lynne A., Martin, Martin G., Dickman, Paul, Goldenring, James R., Shub, Mitchell D.

“…Objectives Microvillus inclusion disease (MVID) is a severe form of neonatal diarrhea, caused mainly by mutations in MYO5B . Inactivating mutations in MYO5B…”
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Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase by Schlegel, Cameron, Lapierre, Lynne A., Weis, Victoria G., Williams, Janice A., Kaji, Izumi, Pinzon‐Guzman, Carolina, Prasad, Nripesh, Boone, Braden, Jones, Angela, Correa, Hernan, Levy, Shawn E., Han, Xianlin, Wang, Miao, Thomsen, Kelly, Acra, Sari, Goldenring, James R.

“…Deficiency in diacylglycerol acyltransferase (DGAT1) is a rare cause of neonatal diarrhea, without a known mechanism or in vitro model. A patient presenting at…”
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Dynamic Expansion of Gastric Mucosal Doublecortin-Like Kinase 1–Expressing Cells in Response to Parietal Cell Loss Is Regulated by Gastrin by Choi, Eunyoung, Petersen, Christine P, Lapierre, Lynne A, Williams, Janice A, Weis, Victoria G, Goldenring, James R, Nam, Ki Taek

“…Doublecortin-like kinase 1 (Dclk1) is considered a reliable marker for tuft cells in the gastrointestinal tract. We investigated the dynamic changes of tuft…”
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Recruitment of Polarity Complexes and Tight Junction Proteins to the Site of Apical Bulk Endocytosis by Engevik, Amy C., Krystofiak, Evan S., Kaji, Izumi, Meyer, Anne R., Weis, Victoria G., Goldstein, Anna, Coutts, Alexander W., Melkamu, Tamene, Saqui-Salces, Milena, Goldenring, James R.

“…The molecular motor, Myosin Vb (MYO5B), is well documented for its role in trafficking cargo to the apical membrane of epithelial cells. Despite its…”
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109 Myosin VB Germline Knockout Mice Display Microvillus Inclusions in Intestinal Enterocytes and Failure to Thrive by Weis, Victoria G, Knowles, Byron, Choi, Eunyoung, Goldstein, Anna E, Goldenring, James R

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Deficits in Enterocyte Apical Transporters Associated with Loss of Myosin VB by Engevik, Amy C, Weis, Victoria G, Knowles, Byron C, Schlegel, Cameron, Ameen, Nadia A, Koepsell, Hermann, Zachos, Nicholas C, Donowitz, Mark, Goldenring, James R

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267 Macrophages Promote the Progression of Metaplasia in the Stomach Following Acute Parietal Cell Loss by Petersen, Christine, Weis, Victoria G, Sousa, Josane F, Nam, Ki Taek, Fingleton, Barbara, Goldenring, James R

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