Excessive fluid intake as a novel cause of proteinuria

Excessive fluid intake as a novel cause of proteinuria

As part of a community screening study to assess the long-term health outcomes among residents of Walkerton, Ontario, after contamination of its municipal water supply by Escherichia coli O157:H7 and Campylobacter in 2000, we identified 100 adults who had proteinuria and polyuria but no medical hist...

Full description

Saved in:
Bibliographic Details
Published in:Canadian Medical Association journal (CMAJ) Vol. 178; no. 2; pp. 173 - 175
Main Authors: Clark, William F, Kortas, Claude, Suri, Rita S, Moist, Louise M, Salvadori, Marina, Weir, Matt A, Garg, Amit X
Format: Journal Article
Language:English
Published: Canada CMA Impact Inc 15-01-2008
CMA Impact, Inc
Canadian Medical Association
Series:Research letter
Subjects:
Campylobacter
Causes of
Cohort Studies
Drinking
Drinking water
Escherichia coli
Female
Humans
Incidence
Longitudinal Studies
Male
Medical research
Proteins
Proteinuria
Proteinuria - epidemiology
Proteinuria - etiology
Risk Assessment
Sensitivity and Specificity
Surveys and Questionnaires
Urinalysis
Urination disorders
Water-Electrolyte Imbalance - epidemiology
Water-Electrolyte Imbalance - etiology
Canada
Walkerton Ontario Canada
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As part of a community screening study to assess the long-term health outcomes among residents of Walkerton, Ontario, after contamination of its municipal water supply by Escherichia coli O157:H7 and Campylobacter in 2000, we identified 100 adults who had proteinuria and polyuria but no medical history or medication use to explain their condition. Fifty-six of the 100 participants underwent both initial and confirmatory urine concentration tests, which showed that their urine osmolality could reach normal levels. We then instructed them to reduce their fluid intake to less than 2 L/d for 1 week. The proteinuria and polyuria were largely reversed by this manoeuvre. We do not know at this time whether the proteinuria associated with excessive fluid intake in these otherwise healthy people will affect their kidney function in the long term.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0820-3946
1488-2329
DOI:10.1503/cmaj.070792