Search Results - "Weir, Lawrence"

Therapeutic Angiogenesis Following Arterial Gene Transfer of Vascular Endothelial Growth Factor in a Rabbit Model of Hindlimb Ischemia by Takeshita, Satoshi, Weir, Lawrence, Chen, Dongfen, Zheng, Lu P., Riessen, Reimer, Bauters, Christophe, Symes, James F., Ferrara, Napoleone, Isner, Jeffrey M.

“…The plasmid phVEGF165, expressing the 165-amino-acid isoform of vascular endothelial growth factor (VEGF), an endothelial cell specific mitogen, was applied to…”
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Expression of gax, a Growth Arrest Homeobox Gene, Is Rapidly Down-regulated in the Rat Carotid Artery during the Proliferative Response to Balloon Injury (∗) by Weir, Lawrence, Chen, Dongfen, Pastore, Christopher, Isner, Jeffrey M., Walsh, Kenneth

“…gax is a recently described homeobox gene whose expression in the adult is largely confined to cardiovascular tissues. gax has been shown to be rapidly…”
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Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy by Simons, Michael, Leclerc, Guy, Safian, Robert D, Isner, Jeffrey M, Weir, Lawrence, Baim, Donald S

“…Restenosis after coronary angioplasty is a major clinical problem. Within six months, clinically important stenosis recurs at the site of angioplasty in 35 to…”
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Smooth muscle cell outgrowth from human atherosclerotic plaque: Implications for the assessment of lesion biology by Pickering, J.Geoffrey, Weir, Lawrence, Rosenfield, Kenneth, Stetz, Joseph, Jekanowski, Jaclynn, Isner, Jeffrey M.

“…Objectives. The purpose of this study was to determine whether the kinetics of smooth muscle cell outgrowth from in vitro explants of human atherosclerotic…”
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An integrated strategy for the discovery of drug targets by the analysis of protein–protein interactions by Peltier, John M., Askovic, Srdjan, Becklin, Robert R., Chepanoske, Cindy Lou, Ho, Yew-Seng J., Kery, Vladimir, Lai, Shuping, Mujtaba, Tahmina, Pyne, Mike, Robbins, Paul B., Rechenberg, Moritz von, Richardson, Bonnie, Savage, Justin, Sheffield, Peter, Thompson, Sam, Weir, Lawrence, Widjaja, Kartika, Xu, Nafei, Zhen, Yuejun, Boniface, J. Jay

“…Proteomics-based technologies have the potential to accelerate the development of drugs, but such technologies must be well integrated in order to have a…”
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Expression of transforming growth factor-β1 is increased in human vascular restenosis lesions by NIKOL, S, ISNER, J. M, GEOFFREY PICKERING, J, KEARNEY, M, LECLERC, G, WEIR, L

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Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease by ISNER, J. M, WALSH, K, SCHAINFELD, R, SYMES, J, PIECZEK, A, TAKESHITA, S, LOWRY, J, ROSSOW, S, ROSENFIELD, K, WEIR, L, BROGI, E

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Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization by PICKERING, J. G, WEIR, L, JEKANOWSKI, J, KEARNEY, M. A, ISNER, J. M

“…We evaluated the proliferative activity of human atherosclerotic lesions associated with active symptoms of ischemia, by assessing the expression of the…”
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Enhancer-Dependent Expression of Human κ Immunoglobulin Genes Introduced into Mouse pre-B Lymphocytes by Electroporation by Potter, Huntington, Weir, Lawrence, Leder, Philip

“…We have developed a general method for introducing cloned genes into mammalian cells that affords substantial benefits over current technology. It is simple,…”
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Percutaneous arterial gene transfer in a rabbit model : efficiency in normal and balloon-dilated atherosclerotic arteries by LECLERC, G, GAL, D, TAKESHITA, S, NIKOL, S, WEIR, L, ISNER, J. M

“…The possibility of using an exclusively percutaneous strategy to deliver foreign DNA to normal and balloon-dilated atherosclerotic arteries was studied by…”
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Human Nonmuscle Myosin Heavy Chains Are Encoded by Two Genes Located on Different Chromosomes by Simons, Michael, Wang, Mary, McBride, Wesley O, Kawamoto, Sachiyo, Yamakawa, Katsutoshi, Gdula, David, Adelstein, Robert S, Weir, Lawrence

“…We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and…”
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Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo : evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression by LOSORDO, D. W, PICKERING, J. G, TAKESHITA, S, LECLERC, G, GAL, D, WEIR, L, KEARNEY, M, JEKANOWSKI, J, ISNER, J. M

“…The development of molecular strategies for the treatment of restenosis has been hindered by low efficiencies of in vivo arterial transfection. Expression of…”
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Liposome-mediated gene transfer into human vascular smooth muscle cells by PICKERING, J. G, JEKANOWSKI, J, WEIR, L, TAKESHITA, S, LOSORDO, D. W, ISNER, J. M

“…Complexing recombinant DNA with cationic liposomes is a convenient means of introducing foreign genes into cells (lipofection) and could potentially form the…”
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803-2 Histological and Molecular Biological Characteristics of Restenotic Sapheneous Vein Grafts Post-Angioplasty by Nikol, Sigrid, Gonschior, Peter, Weir, Lawrence, Isner, Jeffrey, Höfling, Berthold

“…Vascular repair of vein grafts following angioplasty appears to be different from arterial vascular repair. This prompted us to investigate atherectomy…”
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Structure and expression of a human subgroup II immunoglobulin x gene by Weir, Lawrence, Leder, Philip

“…We have determined the entire nucleotide sequence of an active immunoglo-bulin Vk gene of the human subgroup II. Comparison of the main coding sequence of this…”
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Restenosis in human vein bypass grafts by Nikol, Sigrid, Huehns, Tanya Y, Weir, Lawrence, Wight, Thomas N, Höfling, Berthold

“…The restenosis rate in vein bypass grafts is higher than in native coronary arteries, and both the cascade of regulatory factors and the vessel reaction may be…”
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Evidence implicating nonmuscle myosin in restenosis : use of in situ hybridization to analyze human vascular lesions obtained by directional atherectomy by LECLERC, G, ISNER, J. M, KEARNEY, M, SIMONS, M, SAFIAN, R. D, BAIM, D. S, WEIR, L

“…Identification of genes that are specifically activated in restenosis lesions after percutaneous transluminal angioplasty represents a necessary step toward…”
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Processing of chimeric antisense oligonucleotides by human vascular smooth muscle cells in human atherosclerotic plaque by Pickering, J Geoffrey, Isner, Jeffrey M, d, Carol M, Weir, Lawrence

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Transgenic Mice Bearing the Human c-myc Gene Activated by an Immunoglobulin Enhancer: A Pre-B-Cell Lymphoma Model by Schmidt, Emmett V., Pattengale, Paul K., Weir, Lawrence, Leder, Philip

“…Transgenic mice carrying a fusion gene in which the mouse immunoglobulin enhancer has been inserted into an otherwise normal human c-myc gene develop a narrow…”
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Differential expression of nonmuscle myosin II isoforms in human atherosclerotic plaque by Nikol, Sigrid, Murakami, Noriko, Pickering, J.Geoffrey, Kearney, Marianne, Leclerc, Guy, Höfling, Berthold, Isner, Jeffrey M., Weir, Lawrence

“…Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis…”
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