Search Results - "Weir, Jacquelyn"

Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes by Meikle, Peter J, Wong, Gerard, Barlow, Christopher K, Weir, Jacquelyn M, Greeve, Melissa A, MacIntosh, Gemma L, Almasy, Laura, Comuzzie, Anthony G, Mahaney, Michael C, Kowalczyk, Adam, Haviv, Izhac, Grantham, Narelle, Magliano, Dianna J, Jowett, Jeremy B M, Zimmet, Paul, Curran, Joanne E, Blangero, John, Shaw, Jonathan

“…The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly…”
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An Efficient Single Phase Method for the Extraction of Plasma Lipids by Alshehry, Zahir H, Barlow, Christopher K, Weir, Jacquelyn M, Zhou, Youping, McConville, Malcolm J, Meikle, Peter J

“…Lipidomic approaches are now widely used to investigate the relationship between lipid metabolism, health and disease. Large-scale lipidomics studies typically…”
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Plasma lipid profiling in a large population-based cohort[S] by Weir, Jacquelyn M., Wong, Gerard, Barlow, Christopher K., Greeve, Melissa A., Kowalczyk, Adam, Almasy, Laura, Comuzzie, Anthony G., Mahaney, Michael C., Jowett, Jeremy B.M., Shaw, Jonathan, Curran, Joanne E., Blangero, John, Meikle, Peter J.

“…We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000…”
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Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells by Boslem, Ebru, Weir, Jacquelyn M., MacIntosh, Gemma, Sue, Nancy, Cantley, James, Meikle, Peter J., Biden, Trevor J.

“…Chronic saturated fatty acid exposure causes β-cell apoptosis and, thus, contributes to type 2 diabetes. Although endoplasmic reticulum (ER) stress and reduced…”
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Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism by Chaurasia, Bhagirath, Kaddai, Vincent Andre, Lancaster, Graeme Iain, Henstridge, Darren C., Sriram, Sandhya, Galam, Dwight Lark Anolin, Gopalan, Venkatesh, Prakash, K.N. Bhanu, Velan, S. Sendhil, Bulchand, Sarada, Tsong, Teh Jing, Wang, Mei, Siddique, Monowarul Mobin, Yuguang, Guan, Sigmundsson, Kristmundur, Mellet, Natalie A., Weir, Jacquelyn M., Meikle, Peter J., Bin M. Yassin, M. Shabeer, Shabbir, Asim, Shayman, James A., Hirabayashi, Yoshio, Shiow, Sue-Anne Toh Ee, Sugii, Shigeki, Summers, Scott A.

“…Adipocytes package incoming fatty acids into triglycerides and other glycerolipids, with only a fraction spilling into a parallel biosynthetic pathway that…”
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Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease by Meikle, Peter J, Wong, Gerard, Tsorotes, Despina, Barlow, Christopher K, Weir, Jacquelyn M, Christopher, Michael J, MacIntosh, Gemma L, Goudey, Benjamin, Stern, Linda, Kowalczyk, Adam, Haviv, Izhak, White, Anthony J, Dart, Anthony M, Duffy, Stephen J, Jennings, Garry L, Kingwell, Bronwyn A

“…OBJECTIVE—Traditional risk factors for coronary artery disease (CAD) fail to adequately distinguish patients who have atherosclerotic plaques susceptible to…”
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Dietary sphingomyelin lowers hepatic lipid levels and inhibits intestinal cholesterol absorption in high-fat-fed mice by Chung, Rosanna W S, Kamili, Alvin, Tandy, Sally, Weir, Jacquelyn M, Gaire, Raj, Wong, Gerard, Meikle, Peter J, Cohn, Jeffrey S, Rye, Kerry-Anne

“…Controlling intestinal lipid absorption is an important strategy for maintaining lipid homeostasis. Accumulation of lipids in the liver is a major risk factor…”
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An integrative systems genetic analysis of mammalian lipid metabolism by Parker, Benjamin L., Calkin, Anna C., Seldin, Marcus M., Keating, Michael F., Tarling, Elizabeth J., Yang, Pengyi, Moody, Sarah C., Liu, Yingying, Zerenturk, Eser J., Needham, Elise J., Miller, Matthew L., Clifford, Bethan L., Morand, Pauline, Watt, Matthew J., Meex, Ruth C. R., Peng, Kang-Yu, Lee, Richard, Jayawardana, Kaushala, Pan, Calvin, Mellett, Natalie A., Weir, Jacquelyn M., Lazarus, Ross, Lusis, Aldons J., Meikle, Peter J., James, David E., de Aguiar Vallim, Thomas Q., Drew, Brian G.

“…Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are…”
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Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet―Fed Mice by BRUCE, Clinton R, RISIS, Steve, MEIKLE, Peter J, PITSON, Stuart M, FEBBRAIO, Mark A, BABB, Joanne R, YANG, Christine, KOWALSKI, Greg M, SELATHURAI, Ahrathy, LEE-YOUNG, Robert S, WEIR, Jacquelyn M, YOSHIOKA, Kazuaki, TAKUWA, Yoh

“…The sphingolipids sphingosine-1-phosphate (S1P) and ceramide are important bioactive lipids with many cellular effects. Intracellular ceramide accumulation…”
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A distinct plasma lipid signature associated with poor prognosis in castration‐resistant prostate cancer by Lin, Hui‐Ming, Mahon, Kate L., Weir, Jacquelyn M., Mundra, Piyushkumar A., Spielman, Calan, Briscoe, Karen, Gurney, Howard, Mallesara, Girish, Marx, Gavin, Stockler, Martin R., PRIMe Consortium, Parton, Robert G., Hoy, Andrew J., Daly, Roger J., Meikle, Peter J., Horvath, Lisa G.

“…Lipids are known to influence tumour growth, inflammation and chemoresistance. However, the association of circulating lipids with the clinical outcome of…”
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Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome by Khan, Anmar A, Mundra, Piyushkumar A, Straznicky, Nora E, Nestel, Paul J, Wong, Gerard, Tan, Ricardo, Huynh, Kevin, Ng, Theodore W, Mellett, Natalie A, Weir, Jacquelyn M, Barlow, Christopher K, Alshehry, Zahir H, Lambert, Gavin W, Kingwell, Bronwyn A, Meikle, Peter J

“…OBJECTIVE—High-density lipoprotein (HDL) lipid composition and function may better reflect cardiovascular risk than HDL cholesterol concentration. This study…”
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Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations by Moxon, Joseph V., Jones, Rhondda E., Wong, Gerard, Weir, Jacquelyn M., Mellett, Natalie A., Kingwell, Bronwyn A., Meikle, Peter J., Golledge, Jonathan

“…Despite current best care, patients with peripheral artery disease (PAD) remain at high risk of myocardial infarction, and biomarkers to more accurately assess…”
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Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction by Wong, Gerard, Trevillyan, Janine M, Fatou, Benoit, Cinel, Michelle, Weir, Jacquelyn M, Hoy, Jennifer F, Meikle, Peter J

“…The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human…”
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Dose-Dependent Effects of Rosuvastatin on the Plasma Sphingolipidome and Phospholipidome in the Metabolic Syndrome by Ng, Theodore W. K, Ooi, Esther M. M, Watts, Gerald F, Chan, Dick C, Weir, Jacquelyn M, Meikle, Peter J, Barrett, P. Hugh R

“…Context: Statins are effective cholesterol-lowering agents that reduce cardiovascular disease risk but also have pleiotropic effects that may extend to other…”
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Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes by Wong, Gerard, Barlow, Christopher K, Weir, Jacquelyn M, Jowett, Jeremy B M, Magliano, Dianna J, Zimmet, Paul, Shaw, Jonathan, Meikle, Peter J

“…A significant proportion of individuals with diabetes or impaired glucose tolerance have fasting plasma glucose less than 6.1 mmol/L and so are not identified…”
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Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes by Grace, Megan S, Dempsey, Paddy C, Sethi, Parneet, Mundra, Piyushkumar A, Mellett, Natalie A, Weir, Jacquelyn M, Owen, Neville, Dunstan, David W, Meikle, Peter J, Kingwell, Bronwyn A

“…Postprandial dysmetabolism in type 2 diabetes (T2D) is exacerbated by prolonged sitting and may trigger inflammation and oxidative stress. It is unknown what…”
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Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway[S] by Blackburn, Nicholas B., Michael, Laura F., Meikle, Peter J., Peralta, Juan M., Mosior, Marian, McAhren, Scott, Bui, Hai H., Bellinger, Melissa A., Giles, Corey, Kumar, Satish, Leandro, Ana C., Almeida, Marcio, Weir, Jacquelyn M., Mahaney, Michael C., Dyer, Thomas D., Almasy, Laura, VandeBerg, John L., Williams-Blangero, Sarah, Glahn, David C., Duggirala, Ravindranath, Kowala, Mark, Blangero, John, Curran, Joanne E.

“…The de novo ceramide synthesis pathway is essential to human biology and health, but genetic influences remain unexplored. The core function of this pathway is…”
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Plasma Lipidomic Profile Signature of Hypertension in Mexican American Families: Specific Role of Diacylglycerols by Kulkarni, Hemant, Meikle, Peter J., Mamtani, Manju, Weir, Jacquelyn M., Barlow, Christopher K., Jowett, Jeremy B., Bellis, Claire, Dyer, Thomas D., Johnson, Matthew P., Rainwater, David L., Almasy, Laura, Mahaney, Michael C., Comuzzie, Anthony G., Blangero, John, Curran, Joanne E.

“…Both as a component of metabolic syndrome and as an independent entity, hypertension poses a continued challenge with regard to its diagnosis, pathogenesis,…”
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Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis by Overgaard, Anne Julie, Weir, Jacquelyn M., De Souza, David Peter, Tull, Dedreia, Haase, Claus, Meikle, Peter J., Pociot, Flemming

“…The early mechanisms regulating progression towards beta cell failure in type 1 diabetes (T1D) are poorly understood, but it is generally acknowledged that…”
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Lipidomic Profiling in Inflammatory Bowel Disease: Comparison Between Ulcerative Colitis and Crohn's Disease by Fan, Fenling, Mundra, Piyushkumar A, Fang, Lu, Galvin, Abby, Moore, Xiao Lei, Weir, Jacquelyn M, Wong, Gerard, White, David A, Chin-Dusting, Jaye, Sparrow, Miles P, Meikle, Peter J, Dart, Anthony M

“…Inflammatory bowel disease (IBD), which encompasses ulcerative colitis (UC) and Crohn's disease (CD), is believed to be caused by abnormal host immune…”
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