Search Results - "Weir, Gordon"

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes by Weir, Gordon C

“…Reduction of β-cell mass and function is central to the pathogenesis of type 2 diabetes. The terms glucotoxicity, lipotoxicity, and glucolipotoxicity are used…”
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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates by Veiseh, Omid, Doloff, Joshua C., Ma, Minglin, Vegas, Arturo J., Tam, Hok Hei, Bader, Andrew R., Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Siebert, Sean, Tang, Katherine, Hollister-Lock, Jennifer, Aresta-Dasilva, Stephanie, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Chen, Michael, Dholakia, Nimit, Thakrar, Raj, Lacík, Igor, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of…”
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Islet Inflammation Can Be Linked to the Disruption of Proinsulin Processing in Type 1 Diabetes but not in Type 2 Diabetes by Weir, Gordon C

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Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells by Weir, Gordon C., Bonner-Weir, Susan

“…In type 1 diabetes, the reduced glucagon response to insulin-induced hypoglycemia has been used to argue that β-cell secretion of insulin is required for the…”
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Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes by Weir, Gordon C, Gaglia, Jason, Bonner-Weir, Susan

“…For patients with type 1 diabetes, it is accepted among the scientific community that there is a marked reduction in β-cell mass; however, with type 2…”
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Islet β cell mass in diabetes and how it relates to function, birth, and death by Weir, Gordon C., Bonner-Weir, Susan

“…In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes (T2D) results from inadequate β cell mass and function that can no…”
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Reduced glucose-induced first-phase insulin release is a danger signal that predicts diabetes by Weir, Gordon C, Bonner-Weir, Susan

“…During progression to both types 1 and 2 diabetes (T1D, T2D), there is a striking loss of glucose-induced first-phase insulin release (FPIR), which is known to…”
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Induced Pluripotent Stem Cells Generated Without Viral Integration by Stadtfeld, Matthias, Nagaya, Masaki, Utikal, Jochen, Weir, Gordon, Hochedlinger, Konrad

“…Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc. A…”
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A novel cellular engineering approach to diabetes mellitus by Weir, Gordon C.

“…For type 1 diabetes mellitus (T1DM), keeping glucose levels within the normal range of 65–150 mg/dl with administered insulin has had limited success. Now,…”
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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice by Vegas, Arturo J, Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R, Pagliuca, Felicia W, Bader, Andrew R, Doloff, Joshua C, Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James J, Bochenek, Matthew A, Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L, Weir, Gordon C, Melton, Douglas A, Langer, Robert, Anderson, Daniel G

“…When encapsulated with alginate derivatives that resist the foreign-body response, human embryonic stem cell–derived beta cells restore long-term normoglycemia…”
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Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All by Bonner-Weir, Susan, Sullivan, Brooke A., Weir, Gordon C.

“…There has been great interest in understanding how human islets differ from rodent islets. Three major issues about human islet morphology have remained…”
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Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes by Marselli, Lorella, Thorne, Jeffrey, Dahiya, Sonika, Sgroi, Dennis C, Sharma, Arun, Bonner-Weir, Susan, Marchetti, Piero, Weir, Gordon C

“…Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover…”
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GABA Signaling Stimulates β Cell Regeneration in Diabetic Mice by Weir, Gordon C., Bonner-Weir, Susan

“…GABA and the antimalarial drug artemether, which acts on GABAergic pathways, can drive pancreatic cells with an α-cell phenotype toward a β-cell-like…”
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The β-cell glucose toxicity hypothesis: Attractive but difficult to prove by Weir, Gordon C., Butler, Peter C., Bonner-Weir, Susan

“…β cells in the hyperglycemic environment of diabetes have marked changes in phenotype and function that are largely reversible if glucose levels can be…”
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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations by Farah, Shady, Doloff, Joshua C., Müller, Peter, Sadraei, Atieh, Han, Hye Jung, Olafson, Katy, Vyas, Keval, Tam, Hok Hei, Hollister-Lock, Jennifer, Kowalski, Piotr S., Griffin, Marissa, Meng, Ashley, McAvoy, Malia, Graham, Adam C., McGarrigle, James, Oberholzer, Jose, Weir, Gordon C., Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can…”
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β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment by HALBAN, Philippe A, POLONSKY, Kenneth S, BOWDEN, Donald W, HAWKINS, Meredith A, LING, Charlotte, MATHER, Kieren J, POWERS, Alvin C, RHODES, Christopher J, SUSSEL, Lori, WEIR, Gordon C

“…This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may…”
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Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes by Weir, Gordon C., Bonner-Weir, Susan

“…This article proposes five stages in the progression of diabetes, each of which is characterized by different changes in beta-cell mass, phenotype, and…”
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Induction of remission in diabetes by lowering blood glucose by Weir, Gordon C, Bonner-Weir, Susan

“…As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its…”
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Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates by Vegas, Arturo J, Veiseh, Omid, Doloff, Joshua C, Ma, Minglin, Tam, Hok Hei, Bratlie, Kaitlin, Li, Jie, Bader, Andrew R, Langan, Erin, Olejnik, Karsten, Fenton, Patrick, Kang, Jeon Woong, Hollister-Locke, Jennifer, Bochenek, Matthew A, Chiu, Alan, Siebert, Sean, Tang, Katherine, Jhunjhunwala, Siddharth, Aresta-Dasilva, Stephanie, Dholakia, Nimit, Thakrar, Raj, Vietti, Thema, Chen, Michael, Cohen, Josh, Siniakowicz, Karolina, Qi, Meirigeng, McGarrigle, James, Graham, Adam C, Lyle, Stephen, Harlan, David M, Greiner, Dale L, Oberholzer, Jose, Weir, Gordon C, Langer, Robert, Anderson, Daniel G

“…In vivo screening of a large combinatorial library of alginates identifies materials that elicit a substantially reduced foreign body response. The foreign…”
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β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance by Aguayo-Mazzucato, Cristina, van Haaren, Mark, Mruk, Magdalena, Lee, Terence B., Crawford, Caitlin, Hollister-Lock, Jennifer, Sullivan, Brooke A., Johnson, James W., Ebrahimi, Aref, Dreyfuss, Jonathan M., Van Deursen, Jan, Weir, Gordon C., Bonner-Weir, Susan

“…We hypothesized that the known heterogeneity of pancreatic β cells was due to subpopulations of β cells at different stages of their life cycle with different…”
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