Search Results - "Weir, G."

Islet encapsulation: advances and obstacles by Weir, G. C.

“…It has been known for decades that encapsulation can protect transplanted islets from immune destruction in rodents, but it has proved difficult to extend this…”
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endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients by Marchetti, P, Bugliani, M, Lupi, R, Marselli, L, Masini, M, Boggi, U, Filipponi, F, Weir, G. C, Eizirik, D. L, Cnop, M

“…Aims/hypothesis Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been…”
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Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes by Igoillo-Esteve, M, Marselli, L, Cunha, D. A, Ladrière, L, Ortis, F, Grieco, F. A, Dotta, F, Weir, G. C, Marchetti, P, Eizirik, D. L, Cnop, M

“…Aims/hypothesis Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. One of the proposed mechanisms of beta cell failure is local…”
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Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells by Jermendy, A, Toschi, E, Aye, T, Koh, A, Aguayo-Mazzucato, C, Sharma, A, Weir, G. C, Sgroi, D, Bonner-Weir, S

“…Aims/hypothesis Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after…”
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Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies by Bonner-Weir, S., In't Veld, P. A., Weir, G. C.

“…A recently published study by Butler et al. concluded that incretin treatment had adverse effects on the human type 2 diabetic pancreas including ‘a marked…”
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Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice by Papas, K. K., Colton, C. K., Nelson, R. A., Rozak, P. R., Avgoustiniatos, E. S., Scott, W. E., Wildey, G. M., Pisania, A., Weir, G. C., Hering, B. J.

“…There is a need for simple, quantitative and prospective assays for islet quality assessment that are predictive of islet transplantation outcome. The current…”
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Structural Analysis of PdAu Dendrimer-Encapsulated Bimetallic Nanoparticles by Weir, Michael G, Knecht, Marc R, Frenkel, Anatoly I, Crooks, Richard M

“…PdAu dendrimer-encapsulated nanoparticles (DENs) were prepared via sequential reduction of the component metals. When Au is reduced onto 55-atom, preformed Pd…”
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Stellarators Resist Turbulent Transport on the Electron Larmor Scale by Plunk, G G, Xanthopoulos, P, Weir, G M, Bozhenkov, S A, Dinklage, A, Fuchert, G, Geiger, J, Hirsch, M, Hoefel, U, Jakubowski, M, Langenberg, A, Pablant, N, Pasch, E, Stange, T, Zhang, D, W-X Team, The

“…Electron temperature gradient (ETG)-driven turbulence, despite its ultrafine scale, is thought to drive significant thermal losses in magnetic fusion…”
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Origin of Electrochromism in High-Performing Nanocomposite Nickel Oxide by Lin, Feng, Nordlund, Dennis, Weng, Tsu-Chien, Sokaras, Dimosthenis, Jones, Kim M, Reed, Rob B, Gillaspie, Dane T, Weir, Douglas G. J, Moore, Rob G, Dillon, Anne C, Richards, Ryan M, Engtrakul, Chaiwat

“…Electrochromic effects of transition metal oxides provide a great platform for studying lithium intercalation chemistry in solids. Herein, we report on an…”
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Why pancreatic islets should be regarded and regulated like organs by Weir, G C, Bonner-Weir, S

“…There are strong reasons to say that pancreatic islets are organs before they are isolated and that they should be considered to be organs once transplanted…”
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Structural Rearrangement of Bimetallic Alloy PdAu Nanoparticles within Dendrimer Templates to Yield Core/Shell Configurations by Knecht, Marc R, Weir, Michael G, Frenkel, Anatoly I, Crooks, Richard M

“…Here we present evidence for an oxidation-driven structural conversion of quasi-alloy PdAu dendrimer-encapsulated nanoparticles (DENs) to a Au-core/Pd-shell…”
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Investigation of a low frequency coherent mode in Wendelstein 7-X with island divertor by Xiang, H.M., Krämer-Flecken, A., Han, X., Windisch, T., Weir, G., Rahbarnia, K., Schilling, J., Thomsen, H., Mendes, S.vaz, Knieps, A., Vécsei, M., Otte, M., Zoletnik, S., Anda, G., Dunai, D., Zhang, D., Kornejew, P., Huang, J., Zhang, T., Lin, X.D., Gao, X., Liang, Y.

“…Abstract During the island divertor operation of W7-X, especially in standard magnetic configuration (with 5/5 island chain in the scrape-off-layer (SOL)),…”
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Single pancreatic beta cells co-express multiple islet hormone genes in mice by Katsuta, H, Akashi, T, Katsuta, R, Nagaya, M, Kim, D, Arinobu, Y, Hara, M, Bonner-Weir, S, Sharma, A. J, Akashi, K, Weir, G. C

“…Aims/hypothesis It is widely accepted that production of insulin, glucagon, somatostatin and pancreatic polypeptide in islet cells is specific to beta, alpha,…”
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Synthesis and Characterization of Pt Dendrimer-Encapsulated Nanoparticles: Effect of the Template on Nanoparticle Formation by Knecht, Marc R, Weir, Michael G, Myers, V. Sue, Pyrz, William D, Ye, Heechang, Petkov, Valeri, Buttrey, Douglas J, Frenkel, Anatoly I, Crooks, Richard M

“…In this article, we provide a detailed description of the synthesis and properties of Pt dendrimer-encapsulated nanoparticles (DENs) prepared using…”
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Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment by KING, A, LOCK, J, XU, G, BONNER-WEIR, S, WEIR, G. C

“…Although islet transplantation in diabetes holds great promise, two or three donor pancreases are usually required to achieve normoglycaemia in human or rodent…”
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Incidence, Mechanisms, and Characteristics of Injuries in Pole Dancers: A Prospective Cohort Study by Nicholas, J, Weir, G, Alderson, J A, Stubbe, J H, van Rijn, R M, Dimmock, J A, Jackson, B, Donnelly, C J

“…OBJECTIVE: Pole dancing is a challenging physical activity. Prospective injury studies in pole dancing are lacking. The aim of this study was to describe the…”
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Oxygen supply by photosynthesis to an implantable islet cell device by Evron, Y, Zimermann, B, Ludwig, B, Barkai, U, Colton, C K, Weir, G C, Arieli, B, Maimon, S, Shalev, N, Yavriyants, K, Goldman, T, Gendler, Z, Eizen, L, Vardi, P, Bloch, K, Barthel, A, Bornstein, S R, Rotem, A

“…Transplantation of islet cells is an effective treatment for type 1 diabetes with critically labile metabolic control. However, during islet isolation, blood…”
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Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes by Weir, G.C, Marselli, L, Marchetti, P, Katsuta, H, Jung, M.H, Bonner-Weir, S

“…Type 2 diabetes (T2D) is characterized by reduction of β-cell mass and dysfunctional insulin secretion. Understanding β-cell phenotype changes as T2D…”
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The role of preparatory mechanics in modulating knee loads during jump-landing tasks by Noyes, J., Saunders, N., Weir, G., Donnelly, C., Alderson, J., Fox, A.

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Reformation of the Electron Internal Transport Barrier with the Appearance of a Magnetic Island by Kenmochi, N., Minami, T., Mizuuchi, T., Takahashi, C., Weir, G. M., Nishioka, K., Kobayashi, S., Nakamura, Y., Okada, H., Kado, S., Yamamoto, S., Ohshima, S., Konoshima, S., Ohtani, Y., Nagasaki, K.

“…When realising future fusion reactors, their stationary burning must be maintained and the heat flux to the divertor must be reduced. This essentially requires…”
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