Search Results - "Weir, Ashley"

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death by Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.

“…Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated…”
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No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death by Weir, Ashley, Vince, James E

“…For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on the inflammatory caspase, caspase-1, which, upon pathogen sensing, is…”
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Necroptotic movers and shakers: cell types, inflammatory drivers and diseases by Weir, Ashley, Hughes, Sebastian, Rashidi, Maryam, Hildebrand, Joanne M, Vince, James E

“…•MLKL has diverse cellular functions to increase necroptotic-associated inflammation.•Necroptotic cells release molecules distinct from those released by…”
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Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway by Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.

“…Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to Toll-like receptor…”
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The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways by Olivier, Françios A.B., Hilsenstein, Volker, Weerasinghe, Harshini, Weir, Ashley, Hughes, Sebastian, Crawford, Simon, Vince, James E., Hickey, Michael J., Traven, Ana

“…The egress of Candida hyphae from macrophages facilitates immune evasion, but it also alerts macrophages to infection and triggers inflammation. To better…”
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Evaluation of a health and social care programme to improve outcomes following critical illness: a multicentre study by Henderson, Philip, Quasim, Tara, Shaw, Martin, MacTavish, Pamela, Devine, Helen, Daniel, Malcolm, Nicolson, Fiona, O'Brien, Peter, Weir, Ashley, Strachan, Laura, Senior, Lorraine, Lucie, Phil, Bollan, Lynn, Duffty, Jane, Hogg, Lucy, Ross, Colette, Sim, Malcolm, Sundaram, Radha, Iwashyna, Theodore J, McPeake, Joanne

“…At present, clinicians aiming to support patients through the challenges after critical care have limited evidence to base interventions. Evaluate a…”
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Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency by Hughes, Sebastian A, Lin, Meng, Weir, Ashley, Huang, Bing, Xiong, Liya, Chua, Ngee Kiat, Pang, Jiyi, Santavanond, Jascinta P, Tixeira, Rochelle, Doerflinger, Marcel, Deng, Yexuan, Yu, Chien‐Hsiung, Silke, Natasha, Conos, Stephanie A, Frank, Daniel, Simpson, Daniel S, Murphy, James M, Lawlor, Kate E, Pearson, Jaclyn S, Silke, John, Pellegrini, Marc, Herold, Marco J, Poon, Ivan K H, Masters, Seth L, Li, Mingsong, Tang, Qin, Zhang, Yuxia, Rashidi, Maryam, Geng, Lanlan, Vince, James E

“…Genetic lesions in X‐linked inhibitor of apoptosis (XIAP) pre‐dispose humans to cell death–associated inflammatory diseases, although the underlying mechanisms…”
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A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation by Speir, Mary, Tye, Hazel, Gottschalk, Timothy A, Simpson, Daniel S, Djajawi, Tirta M, Deo, Pankaj, Ambrose, Rebecca L, Conos, Stephanie A, Emery, Jack, Abraham, Gilu, Pascoe, Ashlyn, Hughes, Sebastian A, Weir, Ashley, Hawkins, Edwin D, Kong, Isabella, Herold, Marco J, Pearson, Jaclyn S, Lalaoui, Najoua, Naderer, Thomas, Vince, James E, Lawlor, Kate E

“…Abstract Programmed cell death pathways play an important role in innate immune responses to infection. Activation of intrinsic apoptosis promotes infected…”
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CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection by Dalit, Lennard, Alvarado, Carolina, Küijper, Lisan, Kueh, Andrew J, Weir, Ashley, D'Amico, Angela, Herold, Marco J, Vince, James E, Nutt, Stephen L, Groom, Joanna R

“…The chemokine receptor CXCR3 is expressed on immune cells to co-ordinate lymphocyte activation and migration. CXCR3 binds three chemokine ligands, CXCL9,…”
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Profiling the immune landscape in mucinous ovarian carcinoma by Meagher, Nicola S., Hamilton, Phineas, Milne, Katy, Thornton, Shelby, Harris, Bronwyn, Weir, Ashley, Alsop, Jennifer, Bisinoto, Christiani, Brenton, James D., Brooks-Wilson, Angela, Chiu, Derek S., Cushing-Haugen, Kara L., Fereday, Sian, Garsed, Dale W., Gayther, Simon A., Gentry-Maharaj, Aleksandra, Gilks, Blake, Jimenez-Linan, Mercedes, Kennedy, Catherine J., Le, Nhu D., Piskorz, Anna M., Riggan, Marjorie J., Shah, Mitul, Singh, Naveena, Talhouk, Aline, Widschwendter, Martin, Bowtell, David D.L., Candido dos Reis, Francisco J., Cook, Linda S., Fortner, Renée T., García, María J., Harris, Holly R., Huntsman, David G., Karnezis, Anthony N., Köbel, Martin, Menon, Usha, Pharoah, Paul D.P., Doherty, Jennifer A., Anglesio, Michael S., Pike, Malcolm C., Pearce, Celeste Leigh, Friedlander, Michael L., DeFazio, Anna, Nelson, Brad H., Ramus, Susan J.

“…Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherapy, and very poor survival for patients…”
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Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study by Weir, Ashley, Kang, Eun-Young, Meagher, Nicola S., Nelson, Gregg S., Ghatage, Prafull, Lee, Cheng-Han, Riggan, Marjorie J., Gentry-Maharaj, Aleksandra, Ryan, Andy, Singh, Naveena, Widschwendter, Martin, Alsop, Jennifer, Anglesio, Michael S., Beckmann, Matthias W., Berger, Jessica, Bisinotto, Christiani, Boros, Jessica, Brand, Alison H., Brenton, James D., Brooks-Wilson, Angela, Carney, Michael E., Cunningham, Julie M., Cushing-Haugen, Kara L., Cybulski, Cezary, Elishaev, Esther, Erber, Ramona, Fereday, Sian, Fischer, Anna, Paz-Ares, Luis, Gayarre, Javier, Gilks, Blake C., Grube, Marcel, Harnett, Paul R., Harris, Holly R., Hartmann, Arndt, Hein, Alexander, Hendley, Joy, Hernandez, Brenda Y., Heublein, Sabine, Huang, Yajue, Huzarski, Tomasz, Jakubowska, Anna, Jimenez-Linan, Mercedes, Kennedy, Catherine J., Kommoss, Felix K. F., Koziak, Jennifer M., Kraemer, Bernhard, Le, Nhu D., Lesnock, Jaime, Lester, Jenny, Lubiński, Jan, Menkiszak, Janusz, Ney, Britta, Olawaiye, Alexander, Orsulic, Sandra, Osorio, Ana, Robles-Díaz, Luis, Ruebner, Matthias, Shah, Mitul, Sharma, Raghwa, Shvetsov, Yurii B., Steed, Helen, Talhouk, Aline, Taylor, Sarah E., Traficante, Nadia, Vierkant, Robert A., Wang, Chen, Wilkens, Lynne R., Winham, Stacey J., Benitez, Javier, Berchuck, Andrew, Bowtell, David D., Candido dos Reis, Francisco J., Cook, Linda S., DeFazio, Anna, Doherty, Jennifer A., Fasching, Peter A., García, María J., Goode, Ellen L., Goodman, Marc T., Gronwald, Jacek, Huntsman, David G., Karlan, Beth Y., Kommoss, Stefan, Modugno, Francesmary, Schildkraut, Joellen M., Sinn, Hans-Peter, Staebler, Annette, Kelemen, Linda E., Ford, Caroline E., Menon, Usha, Pharoah, Paul D. P., Köbel, Martin, Ramus, Susan J.

“…Background Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a…”
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FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins by Jeon, Yusun, Chow, Seong H, Stuart, Isabella, Weir, Ashley, Yeung, Amy Ty, Hale, Christine, Sridhar, Sushmita, Dougan, Gordon, Vince, James E, Naderer, Thomas

“…causes severe infections such as pneumonia and sepsis depending on the pore-forming toxin Panton-Valentine leukocidin (PVL). PVL kills and induces inflammation…”
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