Search Results - "Weiping, Han"

Gene therapy targeting key beta cell regulators as a potential intervention for diabetes by So, Wing Yan, Han, Weiping

“…Loss of functional beta cells is the central event of all forms of diabetes. Conventional therapies for type 2 diabetes (T2D) fail to preserve beta cells,…”
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O-GlcNAc as an Integrator of Signaling Pathways by Ong, Qunxiang, Han, Weiping, Yang, Xiaoyong

“…O-GlcNAcylation is an important posttranslational modification governed by a single pair of enzymes-O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two…”
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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression by Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping

“…Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a…”
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Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion by Han, Weiping

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Proline Metabolism in Neurological and Psychiatric Disorders by Yao, Yuxiao, Han, Weiping

“…Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes…”
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Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis by Ding, Zhaobing, Ericksen, Russell E., Lee, Qian Yi, Han, Weiping

“…Dysregulated cellular energetics has recently been recognized as a hallmark of cancer and garnered attention as a potential targeting strategy for cancer…”
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Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons by Wang, Xiaorui, Lacza, Zsombor, Sun, Yi E., Han, Weiping

“…Aims/hypothesis Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) regulate energy homeostasis by secreting α-melanocyte-stimulating hormone…”
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222-Nanometer Far-UVC Exposure Results in DNA Damage and Transcriptional Changes to Mammalian Cells by Ong, Qunxiang, Wee, Winson, Dela Cruz, Joshua, Teo, Jin Wah Ronnie, Han, Weiping

“…Ultraviolet (UV) germicidal tools have recently gained attention as a disinfection strategy against the COVID-19 pandemic, but the safety profile arising from…”
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LC-MS/MS analysis reveals plasma protein signatures associated with lymph node metastasis in colorectal cancer by Pang, Chunsong, Xu, Fang, Lin, Yingwei, Han, WeiPing, Zhang, Nianzhu, Zhao, Lifen

“…Objectives Colorectal cancer (CRC) is a major global health concern, ranking as the third most common cancer and the fourth leading cause of cancer-related…”
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Regulation of feeding by somatostatin neurons in the tuberal nucleus by Luo, Sarah Xinwei, Huang, Ju, Li, Qin, Mohammad, Hasan, Lee, Chun-Yao, Krishna, Kumar, Kok, Alison Maun-Yeng, Tan, Yu Lin, Lim, Joy Yi, Li, Hongyu, Yeow, Ling Yun, Sun, Jingjing, He, Miao, Grandjean, Joanes, Sajikumar, Sreedharan, Han, Weiping, Fu, Yu

“…The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit…”
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Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling by Lim, Chun-Yan, Bi, Xuezhi, Wu, Donghai, Kim, Jae Bum, Gunning, Peter W., Hong, Wanjin, Han, Weiping

“…Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass…”
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miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice by Ng, Raymond, Hussain, Nurul Attiqah, Zhang, Qiongyi, Chang, Chengwei, Li, Hongyu, Fu, Yanyun, Cao, Lei, Han, Weiping, Stunkel, Walter, Xu, Feng

“…Brown adipose tissue (BAT) activation and subcutaneous white fat browning are essential components of the thermogenic response to cold stimulus in mammals…”
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Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion by Gustavsson, Natalia, Han, Weiping

“…Neurotransmitters, neuropeptides and hormones are released through the regulated exocytosis of SVs (synaptic vesicles) and LDCVs (large dense-core vesicles), a…”
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Green tea (-)-epigallocatechin-3-gallate counteracts daytime overeating induced by high-fat diet in mice by Li, Hongyu, Kek, Huiling Calvina, Lim, Joy, Gelling, Richard Wayne, Han, Weiping

“…Scope High‐fat diet (HFD) induces overeating and obesity. Green tea (‐)‐epigallocatechin‐3‐gallate (EGCG) reduces HFD‐induced body weight and body fat gain…”
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Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells by Wu, Bingbing, Wei, Shunhui, Petersen, Natalia, Ali, Yusuf, Wang, Xiaorui, Bacaj, Taulant, Rorsman, Patrik, Hong, Wanjin, Südhof, Thomas C., Han, Weiping

“…Glucose stimulates insulin secretion from β-cells by increasing intracellular Ca²⁺. Ca²⁺ then binds to synaptotagmin-7 as a major Ca²⁺ sensor for exocytosis,…”
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Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding by Chen, Naiyan, Sugihara, Hiroki, Kim, Jinah, Fu, Zhanyan, Barak, Boaz, Sur, Mriganka, Feng, Guoping, Han, Weiping

“…Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate…”
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Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy by So, Wing Yan, Liao, Yilie, Liu, Wai Nam, Rutter, Guy A, Han, Weiping

“…Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to…”
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Brefeldin A‐inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons by Liu, Tao, Li, Hongyu, Hong, Wanjin, Han, Weiping

“…ADP‐ribosylation factor (ARF) family of guanine‐nucleotide‐binding (G) proteins regulates organelle biogenesis, structure and trafficking. The functions of ARF…”
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Molecular regulation of insulin granule biogenesis and exocytosis by Röder, Pia V, Wong, Xiuming, Hong, Wanjin, Han, Weiping

“…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance and hyperinsulinemia in early disease stages but a…”
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Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1 by Zhang, Peng, Yu, Jingda, Gui, Yifang, Sun, Cui, Han, Weiping

“…Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and…”
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