Search Results - "Weinstock, David M"

Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry by Pastore, Alessandro, MD, Jurinovic, Vindi, Dipl Math, Kridel, Robert, MD, Hoster, Eva, PhD, Staiger, Annette M, MSc, Szczepanowski, Monika, PhD, Pott, Christiane, MD, Kopp, Nadja, MSc, Murakami, Mark, MD, Horn, Heike, PhD, Leich, Ellen, PhD, Moccia, Alden A, MD, Mottok, Anja, MD, Sunkavalli, Ashwini, MSc, Van Hummelen, Paul, PhD, Ducar, Matthew, MSc, Ennishi, Daisuke, PhD, Shulha, Hennady P, PhD, Hother, Christoffer, MD, Connors, Joseph M, Prof, Sehn, Laurie H, MD, Dreyling, Martin, Prof, Neuberg, Donna, ScD, Möller, Peter, Prof, Feller, Alfred C, Prof, Hansmann, Martin L, Prof, Stein, Harald, Prof, Rosenwald, Andreas, Prof, Ott, German, Prof, Klapper, Wolfram, Prof, Unterhalt, Michael, PhD, Hiddemann, Wolfgang, Prof, Gascoyne, Randy D, Prof, Weinstock, David M, MD, Weigert, Oliver, Dr

“…Summary Background Follicular lymphoma is a clinically and genetically heterogeneous disease, but the prognostic value of somatic mutations has not been…”
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Bruton tyrosine kinase degradation as a therapeutic strategy for cancer by Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.

“…The covalent Bruton tyrosine kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it is not selective for BTK,…”
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High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays by Cermak, Nathan, Olcum, Selim, Delgado, Francisco Feijó, Wasserman, Steven C, Payer, Kristofor R, A Murakami, Mark, Knudsen, Scott M, Kimmerling, Robert J, Stevens, Mark M, Kikuchi, Yuki, Sandikci, Arzu, Ogawa, Masaaki, Agache, Vincent, Baléras, François, Weinstock, David M, Manalis, Scott R

“…Heterogeneity in growth phenotypes and drug susceptibility in bacterial and mammalian cells are assayed at the single-cell level using multiplexed resonant…”
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BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia by Ott, Christopher J., Kopp, Nadja, Bird, Liat, Paranal, Ronald M., Qi, Jun, Bowman, Teresa, Rodig, Scott J., Kung, Andrew L., Bradner, James E., Weinstock, David M.

“…We investigated the therapeutic potential of JQ1, an inhibitor of the BET class of human bromodomain proteins, in B-cell acute lymphoblastic leukemia (B-ALL)…”
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Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy by Jurinovic, Vindi, Kridel, Robert, Staiger, Annette M., Szczepanowski, Monika, Horn, Heike, Dreyling, Martin H., Rosenwald, Andreas, Ott, German, Klapper, Wolfram, Zelenetz, Andrew D., Barr, Paul M., Friedberg, Jonathan W., Ansell, Stephen, Sehn, Laurie H., Connors, Joseph M., Gascoyne, Randy D., Hiddemann, Wolfgang, Unterhalt, Michael, Weinstock, David M., Weigert, Oliver

“…Follicular lymphoma (FL) is a clinically and molecularly heterogeneous disease. Posttreatment surrogate end points, such as progression of disease within 24…”
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miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors by Moskwa, Patryk, Buffa, Francesca M., Pan, Yunfeng, Panchakshari, Rohit, Gottipati, Ponnari, Muschel, Ruth J., Beech, John, Kulshrestha, Ritu, Abdelmohsen, Kotb, Weinstock, David M., Gorospe, Myriam, Harris, Adrian L., Helleday, Thomas, Chowdhury, Dipanjan

“…Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1…”
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Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer by Choi, Young Eun, Meghani, Khyati, Brault, Marie-Eve, Leclerc, Lucas, He, Yizhou J., Day, Tovah A., Elias, Kevin M., Drapkin, Ronny, Weinstock, David M., Dao, Fanny, Shih, Karin K., Matulonis, Ursula, Levine, Douglas A., Konstantinopoulos, Panagiotis A., Chowdhury, Dipanjan

“…High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents…”
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Inhibition of USP10 induces degradation of oncogenic FLT3 by Weisberg, Ellen L, Schauer, Nathan J, Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C, Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M, Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S, Griffin, James D, Buhrlage, Sara J

“…An inhibitor of the deubiquitinase (DUB) USP10 regulates the degradation of oncogenic FLT3, thus defining USP10 as a DUB for FLT3 and providing a therapeutic…”
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DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas by He, Yonghan, Koch, Raphael, Budamagunta, Vivekananda, Zhang, Peiyi, Zhang, Xuan, Khan, Sajid, Thummuri, Dinesh, Ortiz, Yuma T, Zhang, Xin, Lv, Dongwen, Wiegand, Janet S, Li, Wen, Palmer, Adam C, Zheng, Guangrong, Weinstock, David M, Zhou, Daohong

“…Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through…”
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The Evolution of Influenza Resistance and Treatment by Weinstock, David M, Zuccotti, Gianna

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Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions by Yoshida, Noriaki, Shigemori, Kay, Donaldson, Nicholas, Trevisani, Christopher, Cordero, Nicolas A., Stevenson, Kristen E., Bu, Xia, Arakawa, Fumiko, Takeuchi, Mai, Ohshima, Koichi, Yoda, Akinori, Ng, Samuel Y., Weinstock, David M.

“…Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 years and only 5% of patients are <50 years of age. We conducted RNA and targeted…”
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Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia by Sujobert, Pierre, Poulain, Laury, Paubelle, Etienne, Zylbersztejn, Florence, Grenier, Adrien, Lambert, Mireille, Townsend, Elizabeth C., Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa S., Mondesir, Johanna, Hospital, Marie-Anne, Jacque, Nathalie, Christodoulou, Alexandra, Desouza, Tiffany A., Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Mayeux, Patrick, Weinstock, David M., Moura, Ivan C., Bouscary, Didier, Tamburini, Jerome

“…AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context. Here, we report that the…”
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Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate by Stevens, Mark M, Maire, Cecile L, Chou, Nigel, Murakami, Mark A, Knoff, David S, Kikuchi, Yuki, Kimmerling, Robert J, Liu, Huiyun, Haidar, Samer, Calistri, Nicholas L, Cermak, Nathan, Olcum, Selim, Cordero, Nicolas A, Idbaih, Ahmed, Wen, Patrick Y, Weinstock, David M, Ligon, Keith L, Manalis, Scott R

“…The efficacy of cancer drugs is profiled by measuring changes in the mass of single tumor cells. Assays that can determine the response of tumor cells to…”
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Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations by Ajore, Ram, Raiser, David, McConkey, Marie, Jöud, Magnus, Boidol, Bernd, Mar, Brenton, Saksena, Gordon, Weinstock, David M, Armstrong, Scott, Ellis, Steven R, Ebert, Benjamin L, Nilsson, Björn

“…Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and…”
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Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype by Kim, Jung Min, Parmar, Kalindi, Huang, Min, Weinstock, David M., Ruit, Carrie Ann, Kutok, Jeffrey L., D'Andrea, Alan D.

“…Fanconi anemia (FA) is a human genetic disease characterized by chromosome instability, cancer predisposition, and cellular hypersensitivity to DNA…”
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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia by Yoda, Akinori, Yoda, Yuka, Chiaretti, Sabina, Bar-Natan, Michal, Mani, Kartik, Rodig, Scott J, West, Nathan, Xiao, Yun, Brown, Jennifer R, Mitsiades, Constantine, Sattler, Martin, Kutok, Jeffrey L, DeAngelo, Daniel J, Wadleigh, Martha, Piciocchi, Alfonso, Dal Cin, Paola, Bradner, James E, Griffin, James D, Anderson, Kenneth C, Stone, Richard M, Ritz, Jerome, Foà, Robin, Aster, Jon C, Frank, David A, Weinstock, David M

“…The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the…”
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Chromosomal translocations induced at specified loci in human stem cells by Brunet, Erika, Simsek, Deniz, Tomishima, Mark, DeKelver, Russell, Choi, Vivian M, Gregory, Philip, Urnov, Fyodor, Weinstock, David M, Jasin, Maria

“…The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies…”
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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation by Lane, Andrew A, Chapuy, Bjoern, Lin, Charles Y, Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C, van Bodegom, Diederik, Day, Tovah A, Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C, Sullivan, Timothy J, Malinge, Sébastien, Taylor, Jordan E, Stegmaier, Kimberly, Jaffe, Jacob D, Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian H, Stevenson, Kristen E, Neuberg, Donna, Silverman, Lewis B, Sallan, Stephen E, Bradner, James E, Hahn, William C, Crispino, John D, Pellman, David, Weinstock, David M

“…David Weinstock and colleagues identify a triplication at chromosome 21q22 that is associated with development of B cell acute lymphoblastic leukemia (B-ALL)…”
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Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease by Chapuy, Bjoern, Cheng, Hongwei, Watahiki, Akira, Ducar, Matthew D., Tan, Yuxiang, Chen, Linfeng, Roemer, Margaretha G.M., Ouyang, Jing, Christie, Amanda L., Zhang, Liye, Gusenleitner, Daniel, Abo, Ryan P., Farinha, Pedro, von Bonin, Frederike, Thorner, Aaron R., Sun, Heather H., Gascoyne, Randy D., Pinkus, Geraldine S., van Hummelen, Paul, Wulf, Gerald G., Aster, Jon C., Weinstock, David M., Monti, Stefano, Rodig, Scott J., Wang, Yuzhuo, Shipp, Margaret A.

“…Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and…”
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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition by Weigert, Oliver, Lane, Andrew A, Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V, Marubayashi, Sachie, Christie, Amanda L, McKeown, Michael, Paranal, Ronald M, Bradner, James E, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H, Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J, Sallan, Stephen E, Levine, Ross L, Kung, Andrew L, Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M

“…Enzymatic inhibitors of Janus kinase 2 (JAK2) are in clinical development for the treatment of myeloproliferative neoplasms (MPNs), B cell acute lymphoblastic…”
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