Search Results - "Weinstein, J N"

Lumbar Discectomy Outcomes Vary by Herniation Level in the Spine Patient Outcomes Research Trial by Lurie, J.D, Faucett, S.C, Hanscom, B, Tosteson, T.D, Ball, P.A, Abdu, W.A, Frymoyer, J.W, Weinstein, J.N

“…BackgroundThe Spine Patient Outcomes Research Trial showed an overall advantage for operative compared with nonoperative treatment of lumbar disc herniations…”
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Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition by Sheehan, K M, Gulmann, C, Eichler, G S, Weinstein, J N, Barrett, H L, Kay, E W, Conroy, R M, Liotta, L A, Petricoin, E F

“…Molecular crosstalk, including reciprocal stimulation, is theorized to take place between epithelial cancer cells and surrounding non-neoplastic stromal cells…”
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Systematic variation in gene expression patterns in human cancer cell lines by Weinstein, John N, Brown, Patrick O, Ross, Douglas T, Scherf, Uwe, Eisen, Michael B, Perou, Charles M, Rees, Christian, Spellman, Paul, Iyer, Vishwanath, Jeffrey, Stefanie S, Van de Rijn, Matt, Waltham, Mark, Pergamenschikov, Alexander, Lee, Jeffrey C.F, Lashkari, Deval, Shalon, Dari, Myers, Timothy G, Botstein, David

“…We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer…”
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A gene expression database for the molecular pharmacology of cancer by Brown, Patrick O, Weinstein, John N, Scherf, Uwe, Ross, Douglas T, Waltham, Mark, Smith, Lawrence H, Lee, Jae K, Tanabe, Lorraine, Kohn, Kurt W, Reinhold, William C, Myers, Timothy G, Andrews, Darren T, Scudiero, Dominic A, Eisen, Michael B, Sausville, Edward A, Pommier, Yves, Botstein, David

“…We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the National Cancer Institute…”
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Molecular Modeling Studies of the DNA−Topoisomerase I Ternary Cleavable Complex with Camptothecin by Fan, Y, Weinstein, J. N, Kohn, K. W, Shi, L. M, Pommier, Y

“…The present studies provide a three-dimensional model for the postulated ternary cleavable complex of topoisomerase I (top1), DNA, and camptothecin (CPT)…”
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MedMiner: an Internet text-mining tool for biomedical information, with application to gene expression profiling by Tanabe, L, Scherf, U, Smith, L H, Lee, J K, Hunter, L, Weinstein, J N

“…The trend toward high-throughput techniques in molecular biology and the explosion of online scientific data threaten to overwhelm the ability of researchers…”
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The role of steroids and their effects on phospholipase A2: An animal model of radiculopathy by LEE, H.-M, WEINSTEIN, J. N, MELLER, S. T, HAYASHI, N, SPRATT, K. F, GEBHART, G. F

“…The possible role of phospholipase A2 in an animal model for lumbar radiculopathy and mechanisms of epidural steroid injections were studied. To clarify the…”
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Quantitative Structure-Antitumor Activity Relationships of Camptothecin Analogues:  Cluster Analysis and Genetic Algorithm-Based Studies by Fan, Yi, Shi, Leming M, Kohn, Kurt W, Pommier, Yves, Weinstein, John N

“…Topoisomerase 1 (top1) inhibitors are proving useful against a range of refractory tumors, and there is considerable interest in the development of additional…”
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Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents by O'CONNOR, P. M, JACKMAN, J, FRIEND, S, FORNACE, A. J, KOHN, K. W, BAE, I, MYERS, T. G, FAN, S, MUTOH, M, SCUDIERO, D. A, MONKS, A, SAUSVILLE, E. A, WEINSTEIN, J. N

“…In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National Cancer Institute (NCI) anticancer…”
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Predictors of surgical outcome in degenerative lumbar spinal stenosis by KATZ, J. N, STUCKI, G, LIPSON, S. J, FOSSEL, A. H, GROBLER, L. J, WEINSTEIN, J. N

“…A prospective, observational study. To identify outcome predictors of surgery for degenerative lumbar spinal stenosis. Degenerative lumbar spinal stenosis is…”
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The missing piece: embracing shared decision making to reform health care by Weinstein, J N

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The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy by HAYASHI, N, WEINSTEIN, J. N, MELLER, S. T, LEE, H.-M, SPRATT, K. F, GEBHART, G. F

“…The effect of epidural injection of betamethasone or bupivacaine was investigated in an animal model of lumbar radiculopathy. To investigate the effects of an…”
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Pharmacogenomics — Teaching Old Drugs New Tricks by Weinstein, John N

“…Traditionally, cancer treatments have been selected on the basis of tumor type, pathological features, clinical stage, the patient's age and performance…”
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Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data by BLOWER, P. E, YANG, C, FLIGNER, M. A, VERDUCCI, J. S, YU, L, RICHMAN, S, WEINSTEIN, J. N

“…Genomic studies are producing large databases of molecular information on cancers and other cell and tissue types. Hence, we have the opportunity to link these…”
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The Impact of Spinal Problems on the Health Status of Patients: Have We Underestimated the Effect? by Fanuele, Jason C, Birkmeyer, Nancy J. O, Abdu, William A, Tosteson, Tor D, Weinstein, James N

“…STUDY DESIGN.A prospective study of 17,774 patients who consulted spine centers in which the impact of spinal disorders and comorbidities on physical…”
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Spinal glial activation and cytokine expression after lumbar root injury in the rat by Hashizume, H, DeLeo, J A, Colburn, R W, Weinstein, J N

“…This study was designed to examine the behaviorial immunohistochemical changes of spinal glial cells and spinal Interleukin (IL)-1beta expression after various…”
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Artificial neural networks improve the accuracy of cancer survival prediction by Burke, Harry B., Goodman, Philip H., Rosen, David B., Henson, Donald E., Weinstein, John N., Harrell, Frank E., Marks, Jeffrey R., Winchester, David P., Bostwick, David G.

“…BACKGROUND The TNM staging system originated as a response to the need for an accurate, consistent, universal cancer outcome prediction system. Since the TNM…”
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Identification of Epidermal Growth Factor Receptor and c-erbB2 Pathway Inhibitors by Correlation With Gene Expression Patterns by Wosikowski, Katja, Schuurhuis, Danita, Johnson, Kathryn, Bates, Susan E., Paull, Kenneth D., Myers, Timothy G., Weinstein, John N.

“…Background: Growth factor receptor-signaling pathways are potentially important targets for anticancer therapy. The interaction of anticancer agents with…”
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Lumbar laminectomy alone or with instrumented or noninstrumented arthrodesis in degenerative lumbar spinal stenosis patient selection, costs, and surgical outcomes by KATZ, J. N, LIPSON, S. J, LEW, R. A, GROBLER, L. J, WEINSTEIN, J. N, BRICK, G. W, FOSSEL, A. H, LIANG, M. H

“…A prospective, multicenter observational study. 1) Identify correlates of the decision to perform arthrodesis in patients undergoing laminectomy for lumbar…”
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Lumbar discography in normal subjects. A controlled, prospective study by Walsh, T R, Weinstein, J N, Spratt, K F, Lehmann, T R, Aprill, C, Sayre, H

“…Major advances in the techniques of discography since 1968, in conjunction with major strides in the evaluation of pain in recent years, prompted a study in…”
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