Search Results - "Weinstein, Edward A"
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FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development
Published in Antimicrobial agents and chemotherapy (16-12-2020)“…The U.S. Food and Drug Administration (FDA) hosted a public workshop entitled "Advancing Animal Models for Antibacterial Drug Development" on 5 March 2020. The…”
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Inhibitors of Type II NADH:Menaquinone Oxidoreductase Represent a Class of Antitubercular Drugs
Published in Proceedings of the National Academy of Sciences - PNAS (22-03-2005)“…Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term persistence under conditions of low oxygen tension. Analysis of the Mtb…”
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Assessing Animal Models of Bacterial Pneumonia Used in Investigational New Drug Applications for the Treatment of Bacterial Pneumonia
Published in Antimicrobial agents and chemotherapy (21-04-2020)“…Animal models of bacterial infection have been widely used to explore the activity of antibacterial drugs. These data are often submitted to the U.S. Food and…”
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US Food and Drug Administration (FDA): Benefit-Risk Considerations for Cefiderocol (Fetroja®)
Published in Clinical infectious diseases (15-06-2021)“…In November 2019, the Food and Drug Administration (FDA) approved cefiderocol for the treatment of complicated urinary tract infections (cUTI) including…”
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Cefiderocol Dosing for Patients Receiving Continuous Renal Replacement Therapy
Published in Clinical pharmacology and therapeutics (01-11-2022)“…In this report, we describe our scientific approach for including effluent flow rate (QE)–based dosing recommendations of cefiderocol for patients receiving…”
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A Systematic Approach for Developing Bacteria-Specific Imaging Tracers
Published in Journal of Nuclear Medicine (01-01-2017)“…The modern patient is increasingly susceptible to bacterial infections including those due to multidrug-resistant organisms (MDROs). Noninvasive whole-body…”
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Multiple Signaling Pathways Regulate Cell Surface Expression and Activity of the Excitatory Amino Acid Carrier 1 Subtype of Glu Transporter in C6 Glioma
Published in The Journal of neuroscience (01-04-1998)“…Neuronal and glial sodium-dependent transporters are crucial for the control of extracellular glutamate levels in the CNS. The regulation of these transporters…”
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Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging
Published in Antimicrobial agents and chemotherapy (01-09-2015)“…Information about intralesional pharmacokinetics (PK) and spatial distribution of tuberculosis (TB) drugs is limited and has not been used to optimize dosing…”
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Positron Emission Tomography Imaging with 2‑[18F]F‑p‑Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response
Published in ACS infectious diseases (09-11-2018)“…Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and…”
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Nuclear imaging: A powerful novel approach for tuberculosis
Published in Nuclear medicine and biology (01-11-2014)“…Abstract Nearly 20 years after the World Health Organization declared tuberculosis (TB) a global public health emergency, TB still remains a major global…”
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Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography
Published in Science translational medicine (22-10-2014)“…The Enterobacteriaceae are a family of rod-shaped Gram-negative bacteria that normally inhabit the gastrointestinal tract and are the most common cause of…”
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Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis
Published in Journal of bacteriology (01-12-2001)“…The cydAB genes from Mycobacterium smegmatis have been cloned and characterized. The cydA and cydB genes encode the two subunits of a cytochrome bd oxidase…”
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Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease
Published in Biological psychiatry (1969) (01-10-1995)“…Brain lesions have been reported with increasing frequency in the delusional misidentification syndromes (DMS). This is the first controlled study to describe…”
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Prothrombinase Acceleration by Oxidatively Damaged Phospholipids
Published in The Journal of biological chemistry (28-07-2000)“…The optimally efficient production of thrombin by the prothrombinase complex relies on suitable positioning of its component factors and substrate on…”
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Isolation and identification of 1α-hydroxy-24-oxovitamin D3 and 1α,23-dihydroxy-24-oxovitamin D3: Metabolites of 1α,24(R)-dihydroxyvitamin D3 produced in rat kidney
Published in Biochemical pharmacology (15-12-1999)“…1α,24(R)-Dihydroxyvitamin D3 [1α,24(R)(OH)2D3], a synthetic vitamin D3 analog, has been developed as a drug for topical use in the treatment of psoriasis. At…”
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So You Want to Do a Leveraged Buyout
Published in The Journal of business strategy (01-01-1989)“…Some practical advice from two veteran LBO advisers can help potential owner-managers navigate the unexpected twists and turns of this transaction…”
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Disentangling from onerous New York state CPA licensing requirements
Published in The CPA journal (1975) (01-12-2016)Get full text
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Disentangling from Onerous New York State CPA Licensing Requirements
Published in The CPA journal (1975) (01-12-2016)“…[...]a glossary appears one page later and contains 24 words or phrases whose use provides an indication that an individual is in public practice (assuming…”
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Forging Nonprofit Accounting Principles-An Update
Published in The Accounting review (01-10-1980)“…This article continues the discussion which appeared in the October, 1978 issue on the factors which have influenced the AICPA's Subcommittee on Nonprofit…”
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