Search Results - "Weinstein, Edward"

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing by Sato, Kenya, Oiwa, Ryo, Kumita, Wakako, Henry, Rachel, Sakuma, Tetsushi, Ito, Ryoji, Nozu, Ryoko, Inoue, Takashi, Katano, Ikumi, Sato, Kengo, Okahara, Norio, Okahara, Junko, Shimizu, Yoshihisa, Yamamoto, Masafumi, Hanazawa, Kisaburo, Kawakami, Takao, Kametani, Yoshie, Suzuki, Ryuji, Takahashi, Takeshi, Weinstein, Edward J., Yamamoto, Takashi, Sakakibara, Yasubumi, Habu, Sonoko, Hata, Jun-ichi, Okano, Hideyuki, Sasaki, Erika

“…Recent advances in genome editing have facilitated the generation of nonhuman primate (NHP) models, with potential to unmask the complex biology of human…”
Get full text

Targeted genome modification in mice using zinc-finger nucleases by Carbery, Iara D, Ji, Diana, Harrington, Anne, Brown, Victoria, Weinstein, Edward J, Liaw, Lucy, Cui, Xiaoxia

“…Homologous recombination-based gene targeting using Mus musculus embryonic stem cells has greatly impacted biomedical research. This study presents a powerful…”
Get full text

Assessing Animal Models of Bacterial Pneumonia Used in Investigational New Drug Applications for the Treatment of Bacterial Pneumonia by Waack, Ursula, Weinstein, Edward A, Farley, John J

“…Animal models of bacterial infection have been widely used to explore the activity of antibacterial drugs. These data are often submitted to the U.S. Food and…”
Get full text

US Food and Drug Administration (FDA): Benefit-Risk Considerations for Cefiderocol (Fetroja®) by Naseer, Shabnam, Weinstein, Edward A, Rubin, Daniel B, Suvarna, Kalavati, Wei, Xiaohui, Higgins, Karen, Goodwin, Avery, Jang, Seong H, Iarikov, Dmitri, Farley, John, Nambiar, Sumathi

“…In November 2019, the Food and Drug Administration (FDA) approved cefiderocol for the treatment of complicated urinary tract infections (cUTI) including…”
Get full text

Cefiderocol Dosing for Patients Receiving Continuous Renal Replacement Therapy by Wei, Xiaohui, Naseer, Shabnam, Weinstein, Edward A., Iarikov, Dmitri, Nambiar, Sumathi, Reynolds, Kellie S., Jang, Seong H.

“…In this report, we describe our scientific approach for including effluent flow rate (QE)–based dosing recommendations of cefiderocol for patients receiving…”
Get full text

Targeted integration in rat and mouse embryos with zinc-finger nucleases by Cui, Xiaoxia, Ji, Diana, Fisher, Daniel A, Wu, Yumei, Briner, David M, Weinstein, Edward J

“…Gene targeting is indispensible for reverse genetics and the generation of animal models of disease. The mouse has become the most commonly used animal model…”
Get full text

A Systematic Approach for Developing Bacteria-Specific Imaging Tracers by Ordonez, Alvaro A, Weinstein, Edward A, Bambarger, Lauren E, Saini, Vikram, Chang, Yong S, DeMarco, Vincent P, Klunk, Mariah H, Urbanowski, Michael E, Moulton, Kimberly L, Murawski, Allison M, Pokkali, Supriya, Kalinda, Alvin S, Jain, Sanjay K

“…The modern patient is increasingly susceptible to bacterial infections including those due to multidrug-resistant organisms (MDROs). Noninvasive whole-body…”
Get full text

FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development by Byrne, James M, Waack, Ursula, Weinstein, Edward A, Joshi, Abhay, Shurland, Simone M, Iarikov, Dmitri, Bulitta, Jürgen B, Diep, Binh An, Guina, Tina, Hope, William W, Lawrenz, Matthew B, Lepak, Alexander J, Luna, Brian M, Miesel, Lynn, Phipps, Andrew J, Walsh, Thomas J, Weiss, William, Amini, Thushi, Farley, John J

“…The U.S. Food and Drug Administration (FDA) hosted a public workshop entitled "Advancing Animal Models for Antibacterial Drug Development" on 5 March 2020. The…”
Get full text

Whole-rat conditional gene knockout via genome editing by Brown, Andrew J, Fisher, Daniel A, Kouranova, Evguenia, McCoy, Aaron, Forbes, Kevin, Wu, Yumei, Henry, Rachel, Ji, Diana, Chambers, Andre, Warren, Joe, Shu, Weiguo, Weinstein, Edward J, Cui, Xiaoxia

“…Conditional genetic knockout is achieved in the rat by using zinc-finger nucleases to place loxP sites at specific genomic locations and introducing Cre…”
Get full text

Efficient creation of an APOE knockout rabbit by Ji, Diana, Zhao, Guojun, Songstad, Allison, Cui, Xiaoxia, Weinstein, Edward J.

“…The rabbit is a preferred model system for diverse areas of human disease research, such as hypertension and atherosclerosis, for its close resemblance to…”
Get full text

Inhibitors of Type II NADH:Menaquinone Oxidoreductase Represent a Class of Antitubercular Drugs by Weinstein, Edward A., Yano, Takahiro, Li, Lin-Sheng, Avarbock, David, Avarbock, Andrew, Helm, Douglas, McColm, Andrew A., Duncan, Ken, Lonsdale, John T., Rubin, Harvey, Chance, Britton

“…Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term persistence under conditions of low oxygen tension. Analysis of the Mtb…”
Get full text

Small Molecule Regulators of Protein Arginine Methyltransferases by Cheng, Donghang, Yadav, Neelu, King, Randall W, Swanson, Maurice S, Weinstein, Edward J, Bedford, Mark T

“…Here we report the identification of small molecules that specifically inhibit protein arginine N -methyltransferase (PRMT) activity. PRMTs are a family of…”
Get full text

Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging by DeMarco, Vincent P, Ordonez, Alvaro A, Klunk, Mariah, Prideaux, Brendan, Wang, Hui, Zhuo, Zhang, Tonge, Peter J, Dannals, Robert F, Holt, Daniel P, Lee, Carlton K K, Weinstein, Edward A, Dartois, Véronique, Dooley, Kelly E, Jain, Sanjay K

“…Information about intralesional pharmacokinetics (PK) and spatial distribution of tuberculosis (TB) drugs is limited and has not been used to optimize dosing…”
Get full text

Positron Emission Tomography Imaging with 2‑[18F]F‑p‑Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response by Zhang, Zhuo, Ordonez, Alvaro A, Wang, Hui, Li, Yong, Gogarty, Kayla R, Weinstein, Edward A, Daryaee, Fereidoon, Merino, Jonathan, Yoon, Grace E, Kalinda, Alvin S, Mease, Ronnie C, Iuliano, James N, Smith-Jones, Peter M, Jain, Sanjay K, Tonge, Peter J

“…Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and…”
Get full text

Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma by Duan, Zhenfeng, Ji, Diana, Weinstein, Edward J, Liu, Xianzhe, Susa, Michiro, Choy, Edwin, Yang, Cao, Mankin, Henry, Hornicek, Francis J

“…Abstract We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA…”
Get full text

Subphenotypes of self-reported symptoms and outcomes in long COVID: a prospective cohort study with latent class analysis by Kitsios, Georgios D, Blacka, Shawna, Jacobs, Jana J, Mirza, Taaha, Naqvi, Asma, Gentry, Heather, Murray, Cathy, Wang, Xiaohong, Golubykh, Konstantin, Qurashi, Hafiz, Dodia, Akash, Risbano, Michael, Benigno, Michael, Emir, Birol, Weinstein, Edward, Bramson, Candace, Jiang, Lili, Dai, Feng, Szigethy, Eva, Mellors, John W, Methe, Barbara, Sciurba, Frank C, Nouraie, Seyed Mehdi, Morris, Alison

“…ObjectiveTo characterise subphenotypes of self-reported symptoms and outcomes (SRSOs) in postacute sequelae of COVID-19 (PASC).DesignProspective, observational…”
Get full text

Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat by Zschemisch, Nils-Holger, Glage, Silke, Wedekind, Dirk, Weinstein, Edward J, Cui, Xiaoxia, Dorsch, Martina, Hedrich, Hans-Jürgen

“…Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand…”
Get full text

Creation and Preliminary Characterization of a Leptin Knockout Rat by Vaira, Sergio, Yang, Chang, McCoy, Aaron, Keys, Kelly, Xue, Shurong, Weinstein, Edward J, Novack, Deborah V, Cui, Xiaoxia

“…Leptin, a cytokine-like hormone secreted mainly by adipocytes, regulates various pathways centered on food intake and energy expenditure, including insulin…”
Get full text

CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells by Bishop, Kathleen A, Harrington, Anne, Kouranova, Evguenia, Weinstein, Edward J, Rosen, Clifford J, Cui, Xiaoxia, Liaw, Lucy

“…Targeted gene mutation in the mouse is a primary strategy to understand gene function and relation to phenotype. The Knockout Mouse Project (KOMP) had an…”
Get full text

Erratum for DeMarco et al., "Determination of [ 11 C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging" by DeMarco, Vincent P, Ordonez, Alvaro A, Klunk, Mariah, Prideaux, Brendan, Wang, Hui, Zhang, Zhuo, Tonge, Peter J, Dannals, Robert F, Holt, Daniel P, Lee, Carlton K K, Weinstein, Edward A, Dartois, Véronique, Dooley, Kelly E, Jain, Sanjay K

Get full text