Search Results - "Weinreb, Gabriel"

Visinets: a web-based pathway modeling and dynamic visualization tool by Spychala, Jozef, Spychala, Pawel, Gomez, Shawn, Weinreb, Gabriel E

“…In this report we describe a novel graphically oriented method for pathway modeling and a software package that allows for both modeling and visualization of…”
Get full text

Detecting microdomains in intact cell membranes by Lagerholm, B Christoffer, Weinreb, Gabriel E, Jacobson, Ken, Thompson, Nancy L

“…Current models for cellular plasma membranes focus on spatial heterogeneity and how this heterogeneity relates to cell function. In particular, putative lipid…”
Get full text

Factor Xa Binding to Phosphatidylserine-Containing Membranes Produces an Inactive Membrane-Bound Dimer by Koklic, Tilen, Majumder, Rinku, Weinreb, Gabriel E., Lentz, Barry R.

“…Factor Xa (FXa) has a prominent role in amplifying both inflammation and the coagulation cascade. In the coagulation cascade, its main role is catalyzing the…”
Get full text

Analysis of Membrane Fusion as a Two-State Sequential Process: Evaluation of the Stalk Model by Weinreb, Gabriel, Lentz, Barry R.

“…We propose a model that accounts for the time courses of PEG-induced fusion of membrane vesicles of varying lipid compositions and sizes. The model assumes…”
Get full text

Analysis Method for Measuring Submicroscopic Distances with Blinking Quantum Dots by Lagerholm, B. Christoffer, Averett, Laurel, Weinreb, Gabriel E., Jacobson, Ken, Thompson, Nancy L.

“…A method is described that takes advantage of the intermittency (“blinking”) in the fluorescence of quantum dots (QDs) to measure absolute positions of closely…”
Get full text

In silico generation of alternative hypotheses using causal mapping (CMAP) by Weinreb, Gabriel E, Kapustina, Maryna T, Jacobson, Ken, Elston, Timothy C

“…Previously, we introduced causal mapping (CMAP) as an easy to use systems biology tool for studying the behavior of biological processes that occur at the…”
Get full text

Mechanical and Biochemical Modeling of Cortical Oscillations in Spreading Cells by Kapustina, Maryna, Weinreb, Gabriel E., Costigliola, Nancy, Rajfur, Zenon, Jacobson, Ken, Elston, Timothy C.

“…Actomyosin-based cortical contractility is a common feature of eukaryotic cells and is involved in cell motility, cell division, and apoptosis. In nonmuscle…”
Get full text

RhoA Regulates Calcium-Independent Periodic Contractions of the Cell Cortex by Costigliola, Nancy, Kapustina, Maryna T., Weinreb, Gabriel E., Monteith, Andrew, Rajfur, Zenon, Elston, Timothy C., Jacobson, Ken

“…When microtubules are depolymerized in spreading cells, they experience morphological oscillations characterized by a period of about a minute, indicating that…”
Get full text

Soluble Phosphatidylserine Triggers Assembly in Solution of a Prothrombin-activating Complex in the Absence of a Membrane Surface by Majumder, Rinku, Weinreb, Gabriel, Zhai, Xin, Lentz, Barry R.

“…Factor Xa (FXa) binding to factor Va (FVa) on platelet-derived membranes containing surface-exposed phosphatidylserine (PS) forms the “prothrombinase complex”…”
Get full text

Cooperative Roles of Factor Va and Phosphatidylserine-containing Membranes as Cofactors in Prothrombin Activation by Weinreb, Gabriel E., Mukhopadhyay, Kasturi, Majumder, Rinku, Lentz, Barry R.

“…Activation of prothrombin, as catalyzed by the prothrombinase complex (factor X a , enzyme; factor V a and phosphatidylserine (PS)-containing membranes,…”
Get full text

High-throughput thermal denaturation of tryptophanyl-tRNA synthetase combinatorial mutants reveals high-order energetic coupling determinants of conformational stability by Weinreb, Violetta, Weinreb, Gabriel, Carter, Charles W.

“…Landscape descriptions provide a framework for identifying functionally significant dynamic linkages in proteins but cannot supply details. Rate measurements…”
Get full text

Cortical Oscillations as a Model for Studying Cytoskeleton Regulation During Cell Spreading by Costigliola, Nancy, Kapustina, Maryna, Weinreb, Gabriel, Elston, Timothy, Jacobson, Ken

Get full text

Causal mapping as a tool to mechanistically interpret phenomena in cell motility: Application to cortical oscillations in spreading cells by Weinreb, Gabriel E., Elston, Timothy C., Jacobson, Ken

“…Biological processes that occur at the cellular level and consist of large numbers of interacting elements are highly nonlinear and generally involve multiple…”
Get full text

Efficient Thrombin Generation Requires Molecular Phosphatidylserine, Not a Membrane Surface by Majumder, Rinku, Weinreb, Gabriel, Lentz, Barry R

“…Activation of prothrombin to thrombin is catalyzed by a “prothrombinase” complex, traditionally viewed as factor Xa (FXa) in complex with factor Va (FVa) on a…”
Get full text

A Ca2+ Switch Triggers Formation of Inactive Factor Xa Dimers on Phosphatidylserine-Containing Membranes by Koklic, Tilen, Weinreb, Gabriel E., Majumder, Rinku, Lentz, Barry R.

“…Factor Xa has a prominent role in amplifying both inflammation and coagulation cascades. In the coagulation cascade, its main role is catalyzing the…”
Get full text

Efficient Thrombin Generation Requires Molecular Phosphatidylserine, Not a Membrane Surface by Majumder, Rinku, Weinreb, Gabriel E., Lentz, Barry R.

“…Activation of prothrombin to thrombin is catalyzed by “prothrombinase” complex, traditionally viewed as factor Xa (FXa) in complex with factor Va (FVa) on a…”
Get full text

Cooperative roles of factor V(a) and phosphatidylserine-containing membranes as cofactors in prothrombin activation by Weinreb, Gabriel E, Mukhopadhyay, Kasturi, Majumder, Rinku, Lentz, Barry R

“…Activation of prothrombin, as catalyzed by the prothrombinase complex (factor X(a), enzyme; factor V(a) and phosphatidylserine (PS)-containing membranes,…”
Get full text

Role of Procoagulant Lipids in Human Prothrombin Activation. 2. Soluble Phosphatidylserine Upregulates and Directs Factor Xa to Appropriate Peptide Bonds in Prothrombin by Banerjee, Mou, Majumder, Rinku, Weinreb, Gabriel, Wang, Jianfang, Lentz, Barry R

“…Activation of human prothrombin to thrombin (IIa) by factor Xa during blood coagulation requires proteolysis of two bonds and thus involves two possible…”
Get full text

Role of Procoagulant Lipids in Human Prothrombin Activation. 1. Prothrombin Activation by Factor Xa in the Absence of Factor Va and in the Absence and Presence of Membranes by Wu, Jogin R, Zhou, Chaoming, Majumder, Rinku, Powers, Daniel D, Weinreb, Gabriel, Lentz, Barry R

“…Activation of prothrombin by factor Xa requires proteolysis of two bonds and is commonly assumed to occur via by two parallel, sequential pathways. Hydrolysis…”
Get full text

Role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor X(a) to appropriate peptide bonds in prothrombin by Banerjee, Mou, Majumder, Rinku, Weinreb, Gabriel, Wang, Jianfang, Lentz, Barry R

“…Activation of human prothrombin to thrombin (II(a)) by factor X(a) during blood coagulation requires proteolysis of two bonds and thus involves two possible…”
Get full text