Search Results - "Weinmann, Amy S"

Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation by Chisolm, Danielle A, Weinmann, Amy S

“…Researchers are intensifying efforts to understand the mechanisms by which changes in metabolic states influence differentiation programs. An emerging…”
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Bcl-6 directly represses the gene program of the glycolysis pathway by Oestreich, Kenneth J, Read, Kaitlin A, Gilbertson, Sarah E, Hough, Kenneth P, McDonald, Paul W, Krishnamoorthy, Veena, Weinmann, Amy S

“…Cellular metabolism seems to dictate immune responses. Weinmann and colleagues show that the transcription factor Bcl-6 opposes the action of c-Myc and Hif-1α…”
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Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses by Chisolm, Danielle A., Cheng, Wayne, Colburn, Shelby A., Silva-Sanchez, Aaron, Meza-Perez, Selene, Randall, Troy D., Weinmann, Amy S.

“…Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to…”
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Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans by Gilbertson, Sarah E., Walter, Hannah C., Gardner, Katherine, Wren, Spencer N., Vahedi, Golnaz, Weinmann, Amy S.

“…Distinguishing between conserved and divergent regulatory mechanisms is essential for translating preclinical research from mice to humans, yet there is a lack…”
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TCR-Signaling Events in Cellular Metabolism and Specialization by Chisolm, Danielle A, Weinmann, Amy S

“…Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade of signaling events that activates T cells in an antigen-specific manner. It…”
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Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation by Weinmann, Amy S, Farnham, Peggy J

“…The standard chromatin immunoprecipitation (ChIP) assay is used to examine the specific association of transcription factors with DNA in the context of living…”
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Tipping the balance in CD4+ T cells by Weinmann, Amy S.

“…Signaling via T cell antigen receptors is diminished during aging. But paradoxically, CD4 + T cells from older adults tend to differentiate into effector-like…”
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One degree of separation: urgent questions surrounding new USA laws in women’s healthcare by Weinmann, Amy S.

“…The criminalization of women’s healthcare in many USA states has created uncertainty about women’s access to evidence-based medical care and will affect the…”
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Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis by Weinmann, Amy S, Yan, Pearlly S, Oberley, Matthew J, Huang, Tim Hui-Ming, Farnham, Peggy J

“…Previously, identification of promoters regulated by mammalian transcription factors has relied upon overexpression studies. Here we present the identification…”
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Genome regulation in innate and adaptive immune cells by Weinmann, Amy S.

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T-bet Binding to Newly Identified Target Gene Promoters Is Cell Type-independent but Results in Variable Context-dependent Functional Effects by Beima, Kristin M., Miazgowicz, Michael M., Lewis, Megan D., Yan, Pearlly S., Huang, Tim H-M., Weinmann, Amy S.

“…Recently developed target gene identification strategies based upon the chromatin immunoprecipitation assay provide a powerful method to determine the…”
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T-bet's Ability To Regulate Individual Target Genes Requires the Conserved T-Box Domain To Recruit Histone Methyltransferase Activity and a Separate Family Member-Specific Transactivation Domain by Lewis, Megan D., Miller, Sara A., Miazgowicz, Michael M., Beima, Kristin M., Weinmann, Amy S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression by Miller, Sara A., Mohn, Sarah E., Weinmann, Amy S.

“…The stable and heritable H3K27-methyl mark suppresses transcription of lineage-specific genes in progenitor cells. During developmental transitions, histone…”
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Discovering effector domains in human transcription factors by Gilbertson, Sarah E., Weinmann, Amy S.

“…Genomic studies are transforming knowledge about the epigenetic, transcription factor, and 3D landscapes of the genome. However, comprehensive information is…”
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Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors by Oestreich, Kenneth J., Weinmann, Amy S.

“…There has been a tendency to associate the development of distinct CD4 + T cell subsets with the expression of 'master regulator' transcription factors. Here,…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis by Gilbertson, Sarah E., Weinmann, Amy S.

“…Model organisms such as mice are important for basic research and serve as valuable tools in preclinical translational studies. A challenge with translating…”
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NFATc2 and T-Bet Contribute to T-Helper-Cell-Subset-Specific Regulation of IL-21 Expression by Mehta, Devangi S., Wurster, Andrea L., Weinmann, Amy S., Grusby, Michael J., Glimcher, Laurie H.

“…T helper (Th) 2 cells selectively express IL-21 in addition to the classic Th2 cytokines IL-4, IL-5, and IL-13. In contrast to these clustered Th2 cell…”
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CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs by Chisolm, Danielle A., Savic, Daniel, Moore, Amanda J., Ballesteros-Tato, Andre, León, Beatriz, Crossman, David K., Murre, Cornelis, Myers, Richard M., Weinmann, Amy S.

“…Despite considerable research connecting cellular metabolism with differentiation decisions, the underlying mechanisms that translate metabolite-sensitive…”
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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns by Oestreich, Kenneth J, Huang, Albert C, Weinmann, Amy S

“…The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype. Much is known about…”
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