Search Results - "Weinberger, D.R"

Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia by Wallwork, R.S, Fortgang, R, Hashimoto, R, Weinberger, D.R, Dickinson, D

“…Abstract Although the developers of the Positive and Negative Syndrome Scale (PANSS) grouped items into three subscales, factor analyses indicate that a…”
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Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function by Matsumoto, M., Weickert, C.Shannon, Akil, M., Lipska, B.K., Hyde, T.M., Herman, M.M., Kleinman, J.E., Weinberger, D.R.

“…Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. A Val 108/158 Met functional…”
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S.11.01 Gene-environment interaction and prefrontal cortical function as measured by fMRI by Callicott, J, Ihne, J, Ursini, G, Blasi, G, Berman, K.F, Bertolino, A, Weinberger, D.R

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Genetic Contributions to Regional Variability in Human Brain Structure: Methods and Preliminary Results by Wright, I.C., Sham, P., Murray, R.M., Weinberger, D.R., Bullmore, E.T.

“…Twin studies provide one approach for investigating and partitioning genetic and environmental contributions to phenotypic variability in human brain…”
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The Premorbid Adjustment Scale as a measure of developmental compromise in patients with schizophrenia and their healthy siblings by Shapiro, D.I, Marenco, S, Spoor, E.H, Egan, M.F, Weinberger, D.R, Gold, J.M

“…Abstract Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk…”
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P.1.e.015 Emotion cognition interaction located using surface-based versus volume-based analysis by Huf, W, Pail, G, Hartinger, B, Kasess, C, Kasper, S, Mattay, V.S, Meyer-Lindenberg, A, Moser, E, Weinberger, D.R, Pezawas, L

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P.1.e.011 Fronto-limbic interaction of working memory and emotion in the medial prefrontal cortex by Pail, G, Huf, W, Kasess, C, Kasper, S, Moser, E, Brocke, B, Meyer-Lindenberg, A, Mattay, V.S, Weinberger, D.R, Pezawas, L

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Exaggerated MK-801-induced motor hyperactivity in rats with the neonatal lesion of the ventral hippocampus by Al-Amin, H.A, Weinberger, D.R, Lipska, B.K

“…Neonatal lesions of the ventral hippocampus in rats produce changes in spontaneous and pharmacologically induced dopamine-dependent behaviors that emerge in…”
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An investigation of the integrity of semantic boundaries in schizophrenia by Elvevåg, B., Weickert, T., Wechsler, M., Coppola, R., Weinberger, D.R., Goldberg, T.E.

“…Organizing information and knowledge, and hence categorization, requires specifying boundaries between items, concepts and words. Over-inclusiveness in…”
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Gene alteration in zebrafish exposed to a mixture of substances of abuse by Subedi, B., Anderson, S., Croft, T.L., Rouchka, E.C., Zhang, M., Hammond-Weinberger, D.R.

“…A recent surge in the use and abuse of diverse prescribed psychotic and illicit drugs necessitates the surveillance of drug residues in source water and the…”
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Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine D2 pathways by Papaleo, F, Yang, F, Garcia, S, Chen, J, Lu, B, Crawley, J N, Weinberger, D R

“…Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect…”
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Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain by Kaalund, S S, Newburn, E N, Ye, T, Tao, R, Li, C, Deep-Soboslay, A, Herman, M M, Hyde, T M, Weinberger, D R, Lipska, B K, Kleinman, J E

“…Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a…”
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Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans by Meyer-Lindenberg, A, Kolachana, B, Gold, B, Olsh, A, Nicodemus, K K, Mattay, V, Dean, M, Weinberger, D R

“…In mammals, the neuropeptide vasopressin is a key molecule for complex emotional and social behaviours. Two microsatellite polymorphisms, RS1 and RS3, near the…”
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Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans by Papaleo, F, Burdick, M C, Callicott, J H, Weinberger, D R

“…Cognitive functions are highly heritable and the impact of complex genetic interactions, though undoubtedly important, has received little investigation. Here…”
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Serious obstetric complications interact with hypoxia-regulated vascular-expression genes to influence schizophrenia risk by Nicodemus, K K, Marenco, S, Batten, A J, Vakkalanka, R, Egan, M F, Straub, R E, Weinberger, D R

“…The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia…”
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Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression by Kunii, Y, Hyde, T M, Ye, T, Li, C, Kolachana, B, Dickinson, D, Weinberger, D R, Kleinman, J E, Lipska, B K

“…Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B ) has been of interest in schizophrenia owing to its critical…”
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Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression by Pezawas, L, Meyer-Lindenberg, A, Goldman, A L, Verchinski, B A, Chen, G, Kolachana, B S, Egan, M F, Mattay, V S, Hariri, A R, Weinberger, D R

“…Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene–gene interactions are incompletely understood…”
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Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality by Buckholtz, J W, Callicott, J H, Kolachana, B, Hariri, A R, Goldberg, T E, Genderson, M, Egan, M F, Mattay, V S, Weinberger, D R, Meyer-Lindenberg, A

“…Little is known about neural mechanisms underlying human personality and temperament, despite their considerable importance as highly heritable risk mediators…”
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Allelic variation in GAD1 (GAD ) is associated with schizophrenia and influences cortical function and gene expression by STRAUB, R. E, LIPSKA, B. K, EGAN, M. F, GOLDBERG, T. E, CALLICOTT, J. H, MAYHEW, M. B, VAKKALANKA, R. K, KOLACHANA, B. S, KLEINMAN, J. E, WEINBERGER, D. R

“…Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the…”
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Increased expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA by Punzi, G, Ursini, G, Shin, J H, Kleinman, J E, Hyde, T M, Weinberger, D R

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