Search Results - "Weinberg, Peter D"

Computation in the rabbit aorta of a new metric – the transverse wall shear stress – to quantify the multidirectional character of disturbed blood flow by Peiffer, Véronique, Sherwin, Spencer J, Weinberg, Peter D

“…Abstract Spatial variation of the haemodynamic stresses acting on the arterial wall is commonly assumed to explain the focal development of atherosclerosis…”
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Haemodynamic Wall Shear Stress, Endothelial Permeability and Atherosclerosis-A Triad of Controversy by Weinberg, Peter D

“…A striking feature of atherosclerosis is its patchy distribution within the vascular system; certain arteries and certain locations within each artery are…”
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NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium by Ghim, Mean, Yang, Sung-Wook, David, Kamilah R Z, Eustaquio, Joel, Warboys, Christina M, Weinberg, Peter D

“…Haemodynamic wall shear stress varies from site to site within the arterial system and is thought to cause local variation in endothelial permeability to…”
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A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator by Ghim, Mean, Pang, Kuin T, Arshad, Mehwish, Wang, Xiaomeng, Weinberg, Peter D

“…Effects of shear stress on endothelium are important for the normal physiology of blood vessels and are implicated in the pathogenesis of atherosclerosis. They…”
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Dietary isoflavones in the prevention of cardiovascular disease – A molecular perspective by Rimbach, Gerald, Boesch-Saadatmandi, Christine, Frank, Jan, Fuchs, Dagmar, Wenzel, Uwe, Daniel, Hannelore, Hall, Wendy L., Weinberg, Peter D.

“…The Food and Drugs Administration has approved a health claim for soy based on clinical trials and epidemiological data indicating that high soy consumption is…”
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Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics by Kandangwa, Pratik, Torii, Ryo, Gatehouse, Peter D., Sherwin, Spencer J., Weinberg, Peter D.

“…The patchy distribution of atherosclerosis within the arterial system is consistent with a controlling influence of hemodynamic wall shear stress (WSS)…”
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Receptor-mediated vs fluid-phase transcytosis of LDL by Weinberg, Peter D.

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Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study by Potter, Claire M F, Schobesberger, Sophie, Lundberg, Martina H, Weinberg, Peter D, Mitchell, Jane A, Gorelik, Julia

“…To measure the elongation and compliance of endothelial cells subjected to different patterns of shear stress in vitro, and to compare these parameters with…”
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Wave Intensity Analysis Combined With Machine Learning can Detect Impaired Stroke Volume in Simulations of Heart Failure by Reavette, Ryan M, Sherwin, Spencer J, Tang, Meng-Xing, Weinberg, Peter D

“…Heart failure is treatable, but in the United Kingdom, the 1-, 5- and 10-year mortality rates are 24.1, 54.5 and 75.5%, respectively. The poor prognosis…”
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Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms by Potter, Claire M.F, Lundberg, Martina H, Harrington, Louise S, Warboys, Christina M, Warner, Timothy D, Berson, R. Eric, Moshkov, Alexey V, Gorelik, Julia, Weinberg, Peter D, Mitchell, Jane A

“…OBJECTIVE—The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell…”
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Does low and oscillatory wall shear stress correlate spatially with early atherosclerosis? A systematic review by Peiffer, Veronique, Sherwin, Spencer J, Weinberg, Peter D

“…Low and oscillatory wall shear stress is widely assumed to play a key role in the initiation and development of atherosclerosis. Indeed, some studies have…”
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Twenty-fold difference in hemodynamic wall shear stress between murine and human aortas by Weinberg, Peter D, Ross Ethier, C

“…Abstract Endothelial cells regulate vascular tone and mural remodelling in a shear-dependent manner that is commonly assumed to keep wall shear stress constant…”
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Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root by Van Doormaal, Mark A., Kazakidi, Asimina, Wylezinska, Marzena, Hunt, Anthony, Tremoleda, Jordi L., Protti, Andrea, Bohraus, Yvette, Gsell, Willy, Weinberg, Peter D., Ethier, C. Ross

“…Mice are widely used to investigate atherogenesis, which is known to be influenced by stresses related to blood flow. However, numerical characterization of…”
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Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular…”
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Mass transport properties of the rabbit aortic wall by Bailey, Emma L, Bazigou, Eleni, Sowinski, Piotr S J, Weinberg, Peter D

“…Uptake of circulating macromolecules by the arterial wall may be a critical step in atherogenesis. Here we investigate the age-related changes in patterns of…”
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Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model by Mohri, Zahra, Rowland, Ethan M, Clarke, Lindsey A, De Luca, Amalia, Peiffer, Véronique, Krams, Rob, Sherwin, Spencer J, Weinberg, Peter D

“…Atherosclerosis may be triggered by an elevated net transport of lipid-carrying macromolecules from plasma into the arterial wall. We hypothesised that whether…”
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Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method by Warboys, Christina M., Ghim, Mean, Weinberg, Peter D.

“…A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial tree. This has been attributed to variation in the…”
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Application of Fourier transform infrared spectroscopic imaging to the study of effects of age and dietary l-arginine on aortic lesion composition in cholesterol-fed rabbits by Palombo, Francesca, Cremers, Stephanie G., Weinberg, Peter D., Kazarian, Sergei G.

“…-arginine. Immature animals developed lesions at the downstream margin of the branch ostium, whereas lipid deposition was observed at the lateral margins in…”
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Understanding the fluid mechanics behind transverse wall shear stress by Mohamied, Yumnah, Sherwin, Spencer J, Weinberg, Peter D

“…Abstract The patchy distribution of atherosclerosis within arteries is widely attributed to local variation in haemodynamic wall shear stress (WSS). A…”
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Activation of glutathione peroxidase via Nrf1 mediates genistein’s protection against oxidative endothelial cell injury by Hernandez-Montes, Eva, Pollard, Susan E., Vauzour, David, Jofre-Montseny, Laia, Rota, Cristina, Rimbach, Gerald, Weinberg, Peter D., Spencer, Jeremy P.E.

“…Cellular actions of isoflavones may mediate the beneficial health effects associated with high soy consumption. We have investigated protection by genistein…”
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