Search Results - "Weinberg, E."

Mitochondria in the Regulation of Innate and Adaptive Immunity by Weinberg, Samuel E., Sena, Laura A., Chandel, Navdeep S.

“…Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles. In the past two decades, mitochondria have emerged as signaling…”
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Mitochondrial control of immunity: beyond ATP by Mehta, Manan M., Weinberg, Samuel E., Chandel, Navdeep S.

“…Key Points Different immune cell subsets use diverse metabolic pathways. In general, inflammatory and suppressive cells each utilize glycolysis and oxidative…”
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Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function by Weinberg, Christina E, Weinberg, Zasha, Hammann, Christian

“…Abstract Small endonucleolytic ribozymes promote the self-cleavage of their own phosphodiester backbone at a specific linkage. The structures of and the…”
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TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions by Martínez-Reyes, Inmaculada, Diebold, Lauren P., Kong, Hyewon, Schieber, Michael, Huang, He, Hensley, Christopher T., Mehta, Manan M., Wang, Tianyuan, Santos, Janine H., Woychik, Richard, Dufour, Eric, Spelbrink, Johannes N., Weinberg, Samuel E., Zhao, Yingming, DeBerardinis, Ralph J., Chandel, Navdeep S.

“…Mitochondrial metabolism is necessary for the maintenance of oxidative TCA cycle function and mitochondrial membrane potential. Previous attempts to decipher…”
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Are Metformin Doses Used in Murine Cancer Models Clinically Relevant? by Chandel, Navdeep S., Avizonis, Dania, Reczek, Colleen R., Weinberg, Samuel E., Menz, Stephan, Neuhaus, Roland, Christian, Sven, Haegebarth, Andrea, Algire, Carolyn, Pollak, Michael

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The mitochondrial respiratory chain is essential for haematopoietic stem cell function by Ansó, Elena, Weinberg, Samuel E., Diebold, Lauren P., Thompson, Benjamin J., Malinge, Sébastien, Schumacker, Paul T., Liu, Xin, Zhang, Yuannyu, Shao, Zhen, Steadman, Mya, Marsh, Kelly M., Xu, Jian, Crispino, John D., Chandel, Navdeep S.

“…Adult and fetal haematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial…”
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CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides by Kostova, Kamena K., Hickey, Kelsey L., Osuna, Beatriz A., Hussmann, Jeffrey A., Frost, Adam, Weinberg, David E., Weissman, Jonathan S.

“…Ribosome stalling leads to recruitment of the ribosome quality control complex (RQC), which targets the partially synthesized polypeptide for proteasomal…”
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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis by Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, Gr Scott, Chandel, Navdeep S

“…Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor…”
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The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs by Guenther, Ulf-Peter, Weinberg, David E., Zubradt, Meghan M., Tedeschi, Frank A., Stawicki, Brittany N., Zagore, Leah L., Brar, Gloria A., Licatalosi, Donny D., Bartel, David P., Weissman, Jonathan S., Jankowsky, Eckhard

“…The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation 1 …”
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Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat by Schwarz, Jean-Marc, Noworolski, Susan M, Wen, Michael J, Dyachenko, Artem, Prior, Jessica L, Weinberg, Melissa E, Herraiz, Laurie A, Tai, Viva W, Bergeron, Nathalie, Bersot, Thomas P, Rao, Madhu N, Schambelan, Morris, Mulligan, Kathleen

“…Context: Consumption of high-fructose diets promotes hepatic fatty acid synthesis (de novo lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear…”
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Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation by Liu, Xin, Zhang, Yuannyu, Ni, Min, Cao, Hui, Signer, Robert A. J., Li, Dan, Li, Mushan, Gu, Zhimin, Hu, Zeping, Dickerson, Kathryn E., Weinberg, Samuel E., Chandel, Navdeep S., DeBerardinis, Ralph J., Zhou, Feng, Shao, Zhen, Xu, Jian

“…Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here…”
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RNAi in Budding Yeast by Drinnenberg, Ines A, Weinberg, David E, Xie, Kathleen T, Mower, Jeffrey P, Wolfe, Kenneth H, Fink, Gerald R, Bartel, David P

“…RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model…”
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Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society by Moulin, Dwight, Boulanger, Aline, Clark, A J, Clarke, Hance, Dao, Thuan, Finley, G A, Furlan, Andrea, Gilron, Ian, Gordon, Allan, Morley-Forster, Patricia K, Sessle, Barry J, Squire, Pamela, Stinson, Jennifer, Taenzer, Paul, Velly, Ana, Ware, Mark A, Weinberg, Erica L, Williamson, Owen D

“…Neuropathic pain (NeP), redefined as pain caused by a lesion or a disease of the somatosensory system, is a disabling condition that affects approximately two…”
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IgE promotes type 2 innate lymphoid cells in murine food allergy by Burton, O. T., Medina Tamayo, J., Stranks, A. J., Miller, S., Koleoglou, K. J., Weinberg, E. O., Oettgen, H. C.

“…Summary Background Mast cells serve an important sentinel function at mucosal barriers and have been implicated as key early inducers of type 2 immune…”
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Detecting Stealth Dark Matter Directly through Electromagnetic Polarizability by Appelquist, T, Berkowitz, E, Brower, R C, Buchoff, M I, Fleming, G T, Jin, X-Y, Kiskis, J, Kribs, G D, Neil, E T, Osborn, J C, Rebbi, C, Rinaldi, E, Schaich, D, Schroeder, C, Syritsyn, S, Vranas, P, Weinberg, E, Witzel, O

“…We calculate the spin-independent scattering cross section for direct detection that results from the electromagnetic polarizability of a composite scalar…”
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Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function by Fu, Zheng, Ye, Jian, Dean, Joseph W., Bostick, John W., Weinberg, Samuel E., Xiong, Lifeng, Oliff, Kristen N., Chen, Zongming E., Avram, Dorina, Chandel, Navdeep S., Zhou, Liang

“…Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of…”
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Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis by Weinberg, Samuel E, Sun, Le Yu, Yang, Allison L, Liao, Jie, Yang, Guang Yu

“…Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is…”
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The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia by Hamanaka, Robert B., Weinberg, Samuel E., Reczek, Colleen R., Chandel, Navdeep S.

“…Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of…”
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A sense of belonging: The role of higher education in retaining quality STEM teachers by Balgopal, Meena M, Weinberg, Andrea E, Sample McMeeking, Laura B, Lin Hunter, Danielle E, Wright, Diane S

“…There is an alarming shortage of qualified STEM teachers in American PK-12 schools. The COVID-19 pandemic may exacerbate this crisis and consequently affect…”
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Editorial: leave it unhooked? Possible benefits of ileostomy over ileal‐pouch‐anal anastomosis in patients with ulcerative colitis and primary sclerosing cholangitis in the setting of liver transplantation by Weinberg, E. M., Reddy, K. R.

“…Linked Content This article is linked to Trivedi et al paper. To view this article visit https://doi.org/10.1111/apt.14828…”
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