Search Results - "Weinberg, A."

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression by Ye, Xin, Weinberg, Robert A

“…The epithelial–mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage…”
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Tumor Metastasis: Molecular Insights and Evolving Paradigms by Valastyan, Scott, Weinberg, Robert A.

“…Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer…”
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Hallmarks of Cancer: The Next Generation by Hanahan, Douglas, Weinberg, Robert A.

“…The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing…”
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The epigenetics of epithelial-mesenchymal plasticity in cancer by Tam, Wai Leong, Weinberg, Robert A

“…Epithelial-mesenchymal transitions (EMTs) are a key requirement for cancer cells to metastasize and colonize in a new environment. Epithelial-mesenchymal…”
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Coming Full Circle—From Endless Complexity to Simplicity and Back Again by Weinberg, Robert A.

“…Cell has celebrated the powers of reductionist molecular biology and its major successes for four decades. Those who have participated in cancer research…”
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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities by Zhang, Yun, Weinberg, Robert A.

“…The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending…”
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The basics of epithelial-mesenchymal transition by Kalluri, Raghu, Weinberg, Robert A

“…The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis,…”
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Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links by Scheel, Christina, Weinberg, Robert A

“…Abstract The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of…”
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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits by Polyak, Kornelia, Weinberg, Robert A

“…Key Points Transitions between epithelial and mesenchymal states underlie epithelial cell plasticity and contribute to tumour progression and intratumoural…”
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A Perspective on Cancer Cell Metastasis by Chaffer, Christine L., Weinberg, Robert A.

“…Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging…”
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Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis by Yang, Jing, Weinberg, Robert A.

“…The epithelial-mesenchymal transition is a highly conserved cellular program that allows polarized, immotile epithelial cells to convert to motile mesenchymal…”
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Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State by Guo, Wenjun, Keckesova, Zuzana, Donaher, Joana Liu, Shibue, Tsukasa, Tischler, Verena, Reinhardt, Ferenc, Itzkovitz, Shalev, Noske, Aurelia, Zürrer-Härdi, Ursina, Bell, George, Tam, Wai Leong, Mani, Sendurai A., van Oudenaarden, Alexander, Weinberg, Robert A.

“…Regulatory networks orchestrated by key transcription factors (TFs) have been proposed to play a central role in the determination of stem cell states…”
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Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells by Kröger, Cornelia, Afeyan, Alexander, Mraz, Jasmin, Eaton, Elinor Ng, Reinhardt, Ferenc, Khodor, Yevgenia L., Thiru, Prathapan, Bierie, Brian, Ye, Xin, Burge, Christopher B., Weinberg, Robert A.

“…Carcinoma cells residing in an intermediate phenotypic state along the epithelial–mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as…”
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Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast by Scheel, Christina, Eaton, Elinor Ng, Li, Sophia Hsin-Jung, Chaffer, Christine L., Reinhardt, Ferenc, Kah, Kong-Jie, Bell, George, Guo, Wenjun, Rubin, Jeffrey, Richardson, Andrea L., Weinberg, Robert A.

“…The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of motility, invasiveness, and self-renewal traits. During both normal…”
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Phenotypic plasticity and epithelial‐mesenchymal transitions in cancer and normal stem cells? by Scheel, Christina, Weinberg, Robert A.

“…Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self‐renew and to generate large populations of more differentiated descendants…”
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Integrin β₁-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs by Shibue, Tsukasa, Weinberg, Robert A

“…The development of metastases is an extended and inefficient process involving multiple steps. The last of these involves the growth of micrometastases into…”
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Cell plasticity and heterogeneity in cancer by Marjanovic, Nemanja D, Weinberg, Robert A, Chaffer, Christine L

“…Heterogeneity within a given cancer arises from diverse cell types recruited to the tumor and from genetic and/or epigenetic differences amongst the cancer…”
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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening by Gupta, Piyush B., Onder, Tamer T., Jiang, Guozhi, Tao, Kai, Kuperwasser, Charlotte, Weinberg, Robert A., Lander, Eric S.

“…Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell…”
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Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas by Dongre, Anushka, Rashidian, Mohammad, Reinhardt, Ferenc, Bagnato, Aaron, Keckesova, Zuzana, Ploegh, Hidde L, Weinberg, Robert A

“…The epithelial-to-mesenchymal transition (EMT) is a cell biological program that confers mesenchymal traits on carcinoma cells and drives their metastatic…”
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Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity by Chaffer, Christine L., Marjanovic, Nemanja D., Lee, Tony, Bell, George, Kleer, Celina G., Reinhardt, Ferenc, D’Alessio, Ana C., Young, Richard A., Weinberg, Robert A.

“…The recent discovery that normal and neoplastic epithelial cells re-enter the stem cell state raised the intriguing possibility that the aggressiveness of…”
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