Search Results - "Weinbaum, Justin S."

Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft by Krawiec, Jeffrey T., PhD, Liao, Han-Tsung, MD, PhD, Kwan, LaiYee (Lily), BS, D'Amore, Antonio, PhD, Weinbaum, Justin S., PhD, Rubin, J. Peter, MD, Wagner, William R., PhD, Vorp, David A., PhD

“…Abstract Objective One of the rate-limiting barriers within the field of vascular tissue engineering is the lengthy fabrication time associated with expanding…”
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Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration by Cunnane, Eoghan M, Weinbaum, Justin S, O'Brien, Fergal J, Vorp, David A

“…Vascular tissue engineering is an area of regenerative medicine that attempts to create functional replacement tissue for defective segments of the vascular…”
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Functional Vascular Tissue Engineering Inspired by Matricellular Proteins by Ramaswamy, Aneesh K, Vorp, David A, Weinbaum, Justin S

“…Modern regenerative medicine, and tissue engineering specifically, has benefited from a greater appreciation of the native extracellular matrix (ECM)…”
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Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification by Black, 3rd, Lauren D, Meyers, Jason D, Weinbaum, Justin S, Shvelidze, Yevgeniya A, Tranquillo, Robert T

“…A high-potential therapy for repairing the heart post-myocardial infarction is the implantation of tissue-engineered myocardium. While several groups have…”
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Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm by Rao, Jayashree, MS, Brown, Bryan N., PhD, Weinbaum, Justin S., PhD, Ofstun, Emily L., BS, Makaroun, Michel S., MD, Humphrey, Jay D., PhD, Vorp, David A., PhD

“…Objective Little is known about the etiologic factors that lead to the occurrence of intraluminal thrombus (ILT) during abdominal aortic aneurysm (AAA)…”
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Mesenchymal Stem Cell-Conditioned Media-Loaded Microparticles Enhance Acute Patency in Silk-Based Vascular Grafts by Lorentz, Katherine L, Marini, Ande X, Bruk, Liza A, Gupta, Prerak, Mandal, Biman B, DiLeo, Morgan V, Weinbaum, Justin S, Little, Steven R, Vorp, David A

“…Coronary artery disease leads to over 360,000 deaths annually in the United States, and off-the-shelf bypass graft options are currently limited and/or have…”
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Deficiency in Microfibril-associated Glycoprotein-1 Leads to Complex Phenotypes in Multiple Organ Systems by Weinbaum, Justin S., Broekelmann, Thomas J., Pierce, Richard A., Werneck, Claudio C., Segade, Fernando, Craft, Clarissa S., Knutsen, Russell H., Mecham, Robert P.

“…Microfibril-associated glycoprotein-1 (MAGP-1) is a small molecular weight component of the fibrillin-rich microfibril. Gene-targeted inactivation of MAGP-1…”
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Extracellular Vesicles Derived from Primary Adipose Stromal Cells Induce Elastin and Collagen Deposition by Smooth Muscle Cells within 3D Fibrin Gel Culture by Cunnane, Eoghan M, Ramaswamy, Aneesh K, Lorentz, Katherine L, Vorp, David A, Weinbaum, Justin S

“…Macromolecular components of the vascular extracellular matrix (ECM), particularly elastic fibers and collagen fibers, are critical for the proper…”
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The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting by Nerger, Bryan A, Jones, Tia M, Rose, Keron W J, Barqué, Anna, Weinbaum, Justin S, Petrie, Ryan J, Chang, Joan, Vanhoutte, Davy, LaDuca, Kendra, Hubmacher, Dirk, Naba, Alexandra

“…The extracellular matrix (ECM) is a complex assembly of macromolecules that provides both architectural support and molecular signals to cells and modulate…”
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Mechanical and matrix effects of short and long-duration exposure to beta-aminopropionitrile in elastase-induced model abdominal aortic aneurysm in mice by Gueldner, Pete H., Marini, Ande X., Li, Bo, Darvish, Cyrus J., Chung, Timothy K., Weinbaum, Justin S., Curci, John A., Vorp, David A.

“…Evaluate the mechanical and matrix effects on abdominal aortic aneurysms (AAA) during the initial aortic dilation and after prolonged exposure to…”
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Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs by Ramaswamy, Aneesh K., Sides, Rachel E., Cunnane, Eoghan M., Lorentz, Katherine L., Reines, Leila M., Vorp, David A., Weinbaum, Justin S.

“…Elastogenesis within the medial layer of the aortic wall involves a cascade of events orchestrated primarily by smooth muscle cells, including transcription of…”
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Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts by Cunnane, Eoghan M., Lorentz, Katherine L., Soletti, Lorenzo, Ramaswamy, Aneesh K., Chung, Timothy K., Haskett, Darren G., Luketich, Samuel K., Tzeng, Edith, D’Amore, Antonio, Wagner, William R., Weinbaum, Justin S., Vorp, David A.

“…Vascular tissue engineering is a field of regenerative medicine that restores tissue function to defective sections of the vascular network by bypass or…”
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Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling by Craft, Clarissa S., Zou, Wei, Watkins, Marcus, Grimston, Susan, Brodt, Michael D., Broekelmann, Thomas J., Weinbaum, Justin S., Teitelbaum, Steven L., Pierce, Richard A., Civitelli, Roberto, Silva, Matthew J., Mecham, Robert P.

“…MAGP1 is an extracellular matrix protein that, in vertebrates, is a ubiquitous component of fibrillin-rich microfibrils. We previously reported that aged…”
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Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis by Gupta, Prerak, Lorentz, Katherine L., Haskett, Darren G., Cunnane, Eoghan M., Ramaswamy, Aneesh K., Weinbaum, Justin S., Vorp, David A., Mandal, Biman B.

“…The success of tissue-engineered vascular graft (TEVG) predominantly relies on the selection of a suitable biomaterial and graft design. Natural biopolymer…”
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Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold by Cunnane, Eoghan M., Davis, Niall F., Cunnane, Connor V., Lorentz, Katherine L., Ryan, Alan J., Hess, Jochen, Weinbaum, Justin S., Walsh, Michael T., O'Brien, Fergal J., Vorp, David A.

“…This study addresses a crucial gap in the literature by characterising the relationship between urethral tissue mechanics, composition and gross structure. We…”
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Extracellular Vesicles Enhance the Remodeling of Cell-Free Silk Vascular Scaffolds in Rat Aortae by Cunnane, Eoghan M, Lorentz, Katherine L, Ramaswamy, Aneesh K, Gupta, Prerak, Mandal, Biman B, O'Brien, Fergal J, Weinbaum, Justin S, Vorp, David A

“…Vascular tissue engineering is aimed at developing regenerative vascular grafts to restore tissue function by bypassing or replacing defective arterial…”
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CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae by Lorentz, Katherine L., Gupta, Prerak, Shehabeldin, Mostafa S., Cunnane, Eoghan M., Ramaswamy, Aneesh K., Verdelis, Konstantinos, DiLeo, Morgan V., Little, Steven R., Weinbaum, Justin S., Sfeir, Charles S., Mandal, Biman B., Vorp, David A.

“…Cardiovascular disease is the leading cause of death worldwide, often associated with coronary artery occlusion. A common intervention for arterial blockage…”
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An exploratory study on the preparation and evaluation of a “same-day” adipose stem cell–based tissue-engineered vascular graft by Haskett, Darren G., Saleh, Kamiel S., Lorentz, Katherine L., Josowitz, Alexander D., Luketich, Samuel K., Weinbaum, Justin S., Kokai, Lauren E., D'Amore, Antonio, Marra, Kacey G., Rubin, J. Peter, Wagner, William R., Vorp, David A.

“…Tissue-engineered vascular grafts containing adipose-derived mesenchymal stem cells offer an alternative to small-diameter vascular grafts currently used in…”
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In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations by Krawiec, Jeffrey T, Weinbaum, Justin S, Liao, Han-Tsung, Ramaswamy, Aneesh K, Pezzone, Dominic J, Josowitz, Alexander D, D'Amore, Antonio, Rubin, J Peter, Wagner, William R, Vorp, David A

“…Many preclinical evaluations of autologous small-diameter tissue-engineered vascular grafts (TEVGs) utilize cells from healthy humans or animals. However,…”
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Fibrin degradation enhances vascular smooth muscle cell proliferation and matrix deposition in fibrin-based tissue constructs fabricated in vitro by Ahmann, Katherine A, Weinbaum, Justin S, Johnson, Sandra L, Tranquillo, Robert T

“…Completely biological tissue replacements can be fabricated by entrapping cells in a molded fibrin gel. Over time, the fibrin is degraded and replaced with…”
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