Search Results - "Wein, Alexander N."

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation by Barwick, Benjamin G., Scharer, Christopher D., Martinez, Ryan J., Price, Madeline J., Wein, Alexander N., Haines, Robert R., Bally, Alexander P. R., Kohlmeier, Jacob E., Boss, Jeremy M.

“…B cells provide humoral immunity by differentiating into antibody-secreting plasma cells, a process that requires cellular division and is linked to DNA…”
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The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus by Jia, Nan, Byrd-Leotis, Lauren, Matsumoto, Yasuyuki, Gao, Chao, Wein, Alexander N., Lobby, Jenna L., Kohlmeier, Jacob E., Steinhauer, David A., Cummings, Richard D.

“…Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the…”
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Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development by Liu, Shihui, Bachran, Christopher, Gupta, Pradeep, Miller-Randolph, Sharmina, Wang, Hailun, Crown, Devorah, Zhang, Yi, Wein, Alexander N, Singh, Rajat, Fattah, Rasem, Leppla, Stephen H

“…To study the role of the diphthamide modification on eukaryotic elongation factor 2 (eEF2), we generated an eEF2 Gly ⁷¹⁷Arg mutant mouse, in which the first…”
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Liver transplantation for post-COVID-19 sclerosing cholangitis by Lee, Angela, Wein, Alexander N, Doyle, Maria B Majella, Chapman, William C

“…Since identified in December 2019, COVID-19 has remained a pandemic across the globe. Although primarily a respiratory illness, the impact of COVID-19 on other…”
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Interactions of High-Affinity Cationic Blockers with the Translocation Pores of B. anthracis, C. botulinum, and C. perfringens Binary Toxins by Bezrukov, Sergey M., Liu, Xian, Karginov, Vladimir A., Wein, Alexander N., Leppla, Stephen H., Popoff, Michel R., Barth, Holger, Nestorovich, Ekaterina M.

“…Cationic β-cyclodextrin derivatives were recently introduced as highly effective, potentially universal blockers of three binary bacterial toxins: anthrax…”
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Key tissue targets responsible for anthrax-toxin-induced lethality by Liu, Shihui, Zhang, Yi, Moayeri, Mahtab, Liu, Jie, Crown, Devorah, Fattah, Rasem J., Wein, Alexander N., Yu, Zu-Xi, Finkel, Toren, Leppla, Stephen H.

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CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways by Wein, Alexander N, McMaster, Sean R, Takamura, Shiki, Dunbar, Paul R, Cartwright, Emily K, Hayward, Sarah L, McManus, Daniel T, Shimaoka, Takeshi, Ueha, Satoshi, Tsukui, Tatsuya, Masumoto, Tomoko, Kurachi, Makoto, Matsushima, Kouji, Kohlmeier, Jacob E

“…Resident memory T cells (T cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T cell populations to…”
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Helical Atropisomers of Strained Phenanthrenes by Photochemistry of Aromatic Pauson-Khand Cycloadducts by Ji, Yining, Khaizourane, Héléa, Wein, Alexander N., Verdaguer, Xavier, Riera, Antoni

“…Norbornene and norbornadiene Pauson–Khand adducts of bis(3,5‐dimethylphenyl)acetylene and bis(3,4,5‐trimethylphenyl)acetylene were prepared. These compounds…”
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Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma by McMaster, Sean R., Wein, Alexander N., Dunbar, Paul R., Hayward, Sarah L., Cartwright, Emily K., Denning, Timothy L., Kohlmeier, Jacob E.

“…Resident memory CD8 T (T RM ) cells in the lung parenchyma (LP) and airways provide heterologous protection against influenza virus challenge. However, scant…”
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Clinical and Histopathologic Characteristics of Recurrent Sarcoidosis in Posttransplant Lungs: 25 Years of Experience by Lu, Liang, Wein, Alexander N., Villanueva, Ana, Jones, Christopher, Anderson, Adam, Ritter, Jon, Lin, Chieh-Yu

“…Lung transplantation is the definitive therapy for end-stage pulmonary sarcoidosis. While recurrent sarcoidosis in allografts has been described in several…”
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Long-term maintenance of lung resident memory T cells is mediated by persistent antigen by Uddbäck, Ida, Cartwright, Emily K., Schøller, Amalie S., Wein, Alexander N., Hayward, Sarah L., Lobby, Jenna, Takamura, Shiki, Thomsen, Allan R., Kohlmeier, Jacob E., Christensen, Jan P.

“…Tissue-resident memory T cells (T RM ) in the lungs are pivotal for protection against repeated infection with respiratory viruses. However, the gradual loss…”
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The Proportion of Female Authors in Oral and Maxillofacial Surgery Literature Has not Changed in 20 Years by Consky, Elizabeth K., Bradshaw, Shenan M., Wein, Alexander N., Abramowicz, Shelly

“…Academic advancement often depends on publications and reflects the leadership within a profession. The present study compared the number of articles written…”
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Key tissue targets responsible for anthrax-toxin-induced lethality by Liu, Shihui, Zhang, Yi, Moayeri, Mahtab, Liu, Jie, Crown, Devorah, Fattah, Rasem J., Wein, Alexander N., Yu, Zu-Xi, Finkel, Toren, Leppla, Stephen H.

“…Bacillus anthracis , the causative agent of anthrax disease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (ET)…”
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Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS‐CoV‐2 by Wein, Alexander N., Liu, Jing, Lin, Chieh‐Yu

“…Background Previous reports of coronavirus disease 2019 (COVID‐19) following lung transplantation generally described a grim prognosis, but these were…”
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NRF2 assessment in discarded liver allografts: A role in allograft function and salvage by Ahmed, Ola, Xu, Min, Zhou, Fangyu, Wein, Alexander N., Upadhya, Gundumi A., Ye, Li, Wong, Brian W., Lin, Yiing, O'Farrelly, Cliona, Chapman, William C.

“…Antioxidant defence mechanisms, such as the nuclear factor‐erythroid 2‐related‐factor‐2 (NRF2) axis, are integral to oxidative stress responses and ischemic…”
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Pulmonary monocytes interact with effector T cells in the lung tissue to drive T RM differentiation following viral infection by Dunbar, Paul R, Cartwright, Emily K, Wein, Alexander N, Tsukamoto, Tetsuo, Tiger Li, Zheng-Rong, Kumar, Nivedha, Uddbäck, Ida E, Hayward, Sarah L, Ueha, Satoshi, Takamura, Shiki, Kohlmeier, Jacob E

“…Lung resident memory CD8 T cells (T ) are critical for protection against respiratory viruses, but the cellular interactions required for their development are…”
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Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection by Dunbar, Paul R., Cartwright, Emily K., Wein, Alexander N., Tsukamoto, Tetsuo, Tiger Li, Zheng-Rong, Kumar, Nivedha, Uddbäck, Ida E., Hayward, Sarah L., Ueha, Satoshi, Takamura, Shiki, Kohlmeier, Jacob E.

“…Lung resident memory CD8 T cells (T RM ) are critical for protection against respiratory viruses, but the cellular interactions required for their development…”
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Development and validation of a decision tree for distinguishing pulmonary adenocarcinomas with mucinous features and metastatic colorectal adenocarcinoma by Wein, Alexander N., Lin, Chieh‐Yu, Ritter, Jon H., Bernadt, Cory T.

“…Background Diagnosis of mucinous carcinomas in the lung on transbronchial biopsy or fine‐needle aspiration (FNA) samples can be difficult for the pathologist,…”
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The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling by Elliott Williams, M., Hardnett, Felica P., Sheth, Anandi N., Wein, Alexander N., Li, Zheng-Rong Tiger, Radzio-Basu, Jessica, Dinh, Chuong, Haddad, Lisa B., Collins, Elizabeth M.B., Ofotokun, Igho, Antia, Rustom, Scharer, Christopher D., Garcia-Lerma, J. Gerardo, Kohlmeier, Jacob E., Swaims-Kohlmeier, Alison

“…Despite their importance for immunity against sexually transmitted infections, the composition of female reproductive tract (FRT) memory T-cell populations in…”
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IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication by Wein, Alexander N, Dunbar, Paul R, McMaster, Sean R, Li, Zheng-Rong Tiger, Denning, Timothy L, Kohlmeier, Jacob E

“…Although influenza virus infection remains a concerning disease for public health, the roles of individual cytokines during the immune response to influenza…”
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