Search Results - "Weimer, T"

Characteristics, properties, and potential applications of circulating cell-free dna in clinical diagnostics: a focus on transplantation by Sherwood, Karen, Weimer, Eric T.

“…The initial discovery of cell-free DNA (cfDNA) in 1948 by Mandel and Metais has led to numerous investigations evaluating the role of cfDNA in various disease…”
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Utilizing principal component analysis in the identification of clinically relevant changes in patient HLA single antigen bead solid phase testing patterns by Cornaby, Caleb, Weimer, Eric T

“…Background HLA antibody testing is essential for successful solid-organ allocation, patient monitoring post-transplant, and risk assessment for both…”
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Unique Molecular Identifier-Based High-Resolution HLA Typing and Transcript Quantitation Using Long-Read Sequencing by Cornaby, Caleb, Montgomery, Maureen C., Liu, Chang, Weimer, Eric T.

“…HLA typing provides essential results for stem cell and solid organ transplants, as well as providing diagnostic benefits for various rheumatology,…”
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Performance Characteristics and Validation of Next-Generation Sequencing for Human Leucocyte Antigen Typing by Weimer, Eric T, Montgomery, Maureen, Petraroia, Rosanne, Crawford, John, Schmitz, John L

“…High-resolution human leukocyte antigen (HLA) matching reduces graft- versus -host disease and improves overall patient survival after hematopoietic stem cell…”
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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice by Horikawa, Mayuka, Weimer, Eric T, DiLillo, David J, Venturi, Guglielmo M, Spolski, Rosanne, Leonard, Warren J, Heise, Mark T, Tedder, Thomas F

“…Pathogens use numerous methods to subvert host immune responses, including the modulation of host IL-10 production by diverse cell types. However, the B cell…”
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Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing by Hughes, Andrew E. O., Montgomery, Maureen C., Liu, Chang, Weimer, Eric T.

“…Introduction While tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not…”
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Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation by Matern, Benedict M, Spierings, Eric, Bandstra, Selle, Madbouly, Abeer, Schaub, Stefan, Weimer, Eric T, Niemann, Matthias

“…Modern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering…”
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Suitability of dried DNA for long-range PCR amplification and HLA typing by next-generation sequencing by Montgomery, Maureen C., Berka, Jordan, Weimer, Eric T.

“…Storage and stable shipment of genomic DNA are of great concern to laboratories that may need to perform testing off archived samples. There are some dry-state…”
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Buccal swab genomic DNA fragmentation predicts likelihood of successful HLA genotyping by next-generation sequencing by Montgomery, Maureen C., Petraroia, Rosanne, Weimer, Eric T.

“…Many clinical human leukocyte antigen (HLA) laboratories are adopting next-generation sequencing (NGS) technology for HLA genotyping. There have been several…”
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Performance of a multiplexed amplicon-based next-generation sequencing assay for HLA typing by Liu, Chang, Duffy, Brian F, Weimer, Eric T, Montgomery, Maureen C, Jennemann, Jo-Ellen, Hill, Rachel, Phelan, Donna, Lay, Lindsay, Parikh, Bijal A

“…Next-generation sequencing (NGS) has enabled efficient high-resolution typing of human leukocyte antigen (HLA) genes with minimal ambiguity. Most commercially…”
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A Fusion Protein Vaccine Containing OprF Epitope 8, OprI, and Type A and B Flagellins Promotes Enhanced Clearance of Nonmucoid Pseudomonas aeruginosa by WEIMER, Eric T, HAIPING LU, KOCK, Nancy D, WOZNIAK, Daniel J, MIZEL, Steven B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa‐FP) by Zollner, S., Schuermann, D., Raquet, E., Mueller‐Cohrs, J., Weimer, T., Pragst, I., Dickneite, G., Schulte, S.

“…Summary Background Recombinant factor VIIa (rFVIIa) is approved for use in controlling bleeding episodes in people with hemophilia who have developed…”
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Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients by Zhu, Jing, Patel, Tejendra, Miller, Jordan A, Torrice, Chad D, Aggarwal, Mehak, Sketch, Margaret R, Alexander, Maurice D, Armistead, Paul M, Coghill, James M, Grgic, Tatjana, Jamieson, Katarzyna J, Ptachcinski, Jonathan R, Riches, Marcie L, Serody, Jonathan S, Schmitz, John L, Shaw, J Ryan, Shea, Thomas C, Suzuki, Oscar, Vincent, Benjamin G, Wood, William A, Rao, Kamakshi V, Wiltshire, Tim, Weimer, Eric T, Crona, Daniel J

“…Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug…”
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The Law for Patient's Rights - Impact for the Surgeon by Weimer, T

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Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin by Metzner, H J, Pipe, S W, Weimer, T, Schulte, S

“…The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due…”
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HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data by Buchkovich, Martin L, Brown, Chad C, Robasky, Kimberly, Chai, Shengjie, Westfall, Sharon, Vincent, Benjamin G, Weimer, Eric T, Powers, Jason G

“…The human leukocyte antigen (HLA) system is a genomic region involved in regulating the human immune system by encoding cell membrane major histocompatibility…”
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HLA Typing by Next-Generation Sequencing: Lessons Learned and Future Applications by Cornaby, Caleb, Weimer, Eric T

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Clinical Validation of NGS technology for HLA: An Early adopter’s perspective by Weimer, Eric T

“…Abstract Clinical validation of NGS for HLA typing has been a topic of interest with many laboratories investigating the merits. NGS has proven effective at…”
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Next-generation sequencing and clinical histocompatibility testing by Cornaby, Caleb, Schmitz, John L., Weimer, Eric T.

“…Histocompatibility testing is essential for donor identification and risk assessment in solid organ and hematopoietic stem cell transplant. Additionally, it is…”
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Using Nanopore Whole-Transcriptome Sequencing for Human Leukocyte Antigen Genotyping and Correlating Donor Human Leukocyte Antigen Expression with Flow Cytometric Crossmatch Results by Montgomery, Maureen C., Liu, Chang, Petraroia, Rosanne, Weimer, Eric T.

“…Transplant centers are increasingly using virtual crossmatching to evaluate recipient and donor compatibility. However, the current state of virtual…”
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